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Protein, Total Test

Protein, Total Test

January 21, 2026
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Do I need a Protein, Total test?

Feeling unexpectedly weak, noticing swelling in your legs, or concerned about unexplained weight changes? Could your protein levels hold answers you've been searching for?

Total protein measures the combined amount of albumin and globulin in your blood, two essential proteins that support immune function, fluid balance, and nutrient transport. When these levels are off, it can signal underlying issues affecting your liver, kidneys, or nutritional status.

Testing your total protein gives you a vital snapshot of your body's protein balance, helping pinpoint whether deficiencies or excesses are contributing to your fatigue or swelling. It's your first step toward a personalized health plan that addresses what's really going on.

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If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone. Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.

Superpower flips that approach. We give you full insight into your body with over 100 biomarkers, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.

With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability - all in one place.

Key benefits of Protein, Total testing

  • Measures total protein in your blood to assess nutritional and organ health.
  • Spots imbalances that may signal liver disease, kidney problems, or malnutrition.
  • Flags unexplained swelling, fatigue, or weight loss for further investigation.
  • Guides treatment decisions for chronic conditions affecting protein balance.
  • Tracks recovery after illness, surgery, or changes in diet or medication.
  • Clarifies immune system function when paired with albumin and globulin levels.
  • Best interpreted with albumin, liver enzymes, and kidney markers for full context.

What is Protein, Total?

Total protein measures the combined amount of all proteins circulating in your blood. These proteins come from two main sources: your liver, which produces most of them, and your immune system, which makes antibodies. Together, they form a diverse workforce of thousands of different molecules.

Proteins are your body's multitaskers

Proteins perform essential jobs throughout your bloodstream. They transport hormones, vitamins, and minerals to where they're needed. They maintain the right balance of fluid between your blood vessels and tissues. They also support immune defense and help your blood clot when you're injured.

A snapshot of nutritional and organ health

Total protein reflects how well your body is making and keeping these vital molecules. It offers a broad view of your nutritional status, liver function, and immune activity. Because it captures the sum of many protein types, it serves as a useful screening tool rather than a specific diagnostic marker.

Why is Protein, Total important?

Total protein measures the combined concentration of albumin and globulins circulating in your blood, offering a window into how well your liver manufactures essential proteins, how your kidneys retain them, and whether your immune system or inflammatory pathways are overactive. This single value reflects the balance between protein synthesis, breakdown, and loss, making it a vital gauge of nutritional status, organ function, and systemic inflammation.

Your liver and kidneys work in tandem

Normal total protein typically ranges from about 6 to 8.5 g/dL, with optimal values sitting comfortably in the middle. When total protein drops below normal, it often signals that your liver isn't producing enough albumin due to chronic liver disease, malnutrition, or malabsorption, or that your kidneys are leaking protein into urine through damaged filters. Low levels can cause fluid to seep into tissues, leading to swelling in the legs and abdomen, fatigue, and weakened immunity.

Elevated protein points to immune activation

When total protein climbs above the reference range, it usually reflects an increase in globulins rather than albumin. Chronic infections, autoimmune diseases, and certain blood cancers like multiple myeloma drive antibody production, thickening the blood and sometimes causing fatigue, bone pain, or recurrent infections.

The big picture on protein balance

Total protein connects liver health, kidney integrity, immune surveillance, and nutritional reserves into one number, serving as an early alert for conditions that silently erode organ function and long-term vitality.

What do my Protein, Total results mean?

Low values and what they reveal

Low values usually reflect inadequate protein production by the liver, excessive protein loss through the kidneys or gut, or dilution from fluid overload. The liver synthesizes most circulating proteins, so chronic liver disease, severe malnutrition, or malabsorption can all reduce total protein. Protein-losing conditions like nephrotic syndrome or inflammatory bowel disease allow protein to escape the body faster than it can be replaced. Overhydration from heart failure or kidney dysfunction dilutes protein concentration without true depletion. Low total protein weakens immune defenses, impairs wound healing, and disrupts fluid balance between blood vessels and tissues, sometimes causing swelling.

Optimal values and system stability

Being in range suggests balanced protein synthesis, intact kidney and gut barriers, and proper fluid distribution. Most healthy adults maintain total protein in the mid to upper portion of the reference range, reflecting steady liver output and minimal loss. This stability supports immune function, tissue repair, and the transport of hormones, nutrients, and medications throughout the body.

High values and their significance

High values usually reflect dehydration concentrating the blood, or less commonly, overproduction of immunoglobulins by plasma cells in conditions like multiple myeloma or chronic infections. True protein excess is rare; most elevations are relative rather than absolute.

Factors that influence interpretation

Pregnancy lends to lower values due to plasma volume expansion. Acute illness, posture, and tourniquet use during blood draw can all shift results modestly.

Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.

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Frequently Asked Questions

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How it works
What should I expect during a blood draw?
  • A trained phlebotomist will guide you through the process.
  • A tourniquet is placed on your arm, the site is cleaned, and a small needle is used to collect blood into one or more tubes.
  • Results are usually ready in about a week.
  • Most people feel only a quick pinch.
  • The needle is removed, gentle pressure is applied, and a bandage is placed.
How do I prepare for a blood draw?
  • Drink plenty of water beforehand — hydration makes veins easier to find.
  • Wear loose sleeves so your arm is easy to access.
  • Follow any fasting instructions you’ve been given.
  • Let us know if you’re on medications, have fainted before, or have needle anxiety.
What should I do after my blood draw?
  • Press gently on the site for a few minutes.
  • Keep the bandage on for 4-6 hours.
  • Skip heavy lifting or strenuous exercise for the rest of the day.
  • Drink extra water to rehydrate.
  • Monitor the site for redness, swelling, or pain.
How do I book a blood draw with Superpower?

Your membership includes:

  • An annual full body test and report across 100+ biomarkers
  • A personalized action plan to optimize your biomarkers and reach your health goals
  • A dashboard to centralize your health data and track changes across a lifetime
  • Access to a health concierge for questions on your plan and help scheduling
  • Plus a marketplace of curated health products and services cheaper than amazon

Many concierge clinics charge $10k – $100k for their services, we’ve built technology to make the world’s best healthcare as accessible as possible via an all-in-one membership.

Where can I take my blood test?

Superpower is currently available in the following US states:

  • Alabama
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Does Superpower replace my primary care provider?

Superpower specializes in prevention-based testing and treatments and is not intended for emergency or immediate health issues.

While you will have a Superpower care team, your annual membership is designed to complement a primary care doctor if you have one, not replace them.

We are happy to help you share any test results with an outside provider to ensure you receive well-rounded medical care.

How fast are blood test results and how do I read them?

Your annual lab test panel takes about a week to process. We will text you as soon as they become available in your dashboard. Other types of tests may have different testing windows. The Superpower concierge is your own health assistant who helps answer your questions on your results, ensure smooth scheduling, coordination of any office-based tests, specialist referrals as needed, and navigating you to interface with your care team.

Does Superpower accept health insurance?

Superpower membership and products are all eligible for HSA/FSA funding.

We see Superpower like a gym membership for those committed to prevention and performance. Superpower is a bridge between wellness and healthcare. Health insurance traditionally focuses on reactive care whereas, at Superpower, we believe it’s never too early to start looking out for your long-term health.

What if I want more than 1 blood test per year?

Absolutely — you're not limited to just one. Your membership includes one comprehensive 100+ biomarker blood test each year, but if you'd like to track your progress more closely, you can add extra tests at any time. Each additional full-panel test costs $179. You can order as many as you'd like throughout the year.

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Frequently Asked Questions about Protein, Total Test

What is a Protein, Total blood test and what does it measure?

Protein, Total is a blood test that measures the combined amount of proteins circulating in your bloodstream, primarily albumin and globulins. Albumin is largely produced by the liver, while many globulins include antibodies made by the immune system. Because it reflects thousands of proteins with different roles, total protein provides a broad snapshot of nutritional status, liver protein production, kidney protein retention, and immune or inflammatory activity.

Why is Protein, Total testing important for liver, kidney, and immune health?

Protein, Total helps screen how well your liver manufactures essential proteins, how effectively your kidneys retain them, and whether immune or inflammatory pathways are overactive. Abnormal results can be an early clue to chronic liver disease, kidney damage with protein loss, chronic infection, autoimmune disorders, or blood conditions that increase globulins. It’s a systems-level marker that often signals when more specific follow-up tests are needed.

What is the normal range for Protein, Total and what is considered optimal?

Typical reference values for Protein, Total are about 6 to 8.3 g/dL. “Optimal” levels are generally described as sitting comfortably in the middle of that range. Interpretation depends on the balance of albumin and globulins and your clinical context, including hydration status, recent illness, pregnancy, and age. Protein, Total is best assessed alongside albumin and globulin levels for a complete picture.

What does low Protein, Total mean and what are the most common causes?

Low Protein, Total often reflects inadequate protein intake, poor absorption in the gut, reduced liver production during chronic illness or advanced liver disease, or excessive protein loss through the kidneys or digestive tract. Common contributors include malnutrition, inflammatory bowel disease, nephrotic syndrome, and severe burns. Low protein can reduce fluid retention in blood vessels, leading to swelling (edema), fatigue, slower wound healing, and weaker immune or clotting function.

What symptoms can low Protein, Total cause, like swelling or fatigue?

Low total protein can reduce the blood’s ability to keep fluid inside blood vessels, causing fluid to leak into tissues and produce swelling in the legs or abdomen (edema). It may also contribute to fatigue due to impaired nutrient transport and reduced overall resilience during illness. Slower wound healing and lowered immune support can occur because many proteins are needed for repair and defense. Symptoms can be subtle until levels are significantly low.

What does high Protein, Total mean and is dehydration the most common reason?

High Protein, Total is most commonly due to dehydration, which concentrates blood components and makes protein levels appear elevated. True increases can also reflect immune activation with higher globulin production, such as in chronic infections, autoimmune disorders, or blood cancers like multiple myeloma. Symptoms may be minimal early on, so an elevated result can serve as an early clue. Hydration status and globulin-related causes should be considered.

How do albumin and globulin relate to Protein, Total, and why is the ratio important?

Protein, Total is the combined concentration of albumin plus globulins. Albumin largely reflects liver production and helps maintain fluid balance, while globulins often reflect immune activity and antibody levels. Looking at albumin, globulins, and the albumin-to-globulin (A/G) ratio can help determine whether an abnormal total protein is driven by low albumin, high globulins, or both. This “complete protein picture” guides more targeted evaluation.

How can Protein, Total results help explain unexplained weight changes, swelling, or chronic fatigue?

Protein, Total can help connect symptoms to underlying physiology. Low total protein can contribute to swelling from fluid shifting into tissues and can worsen fatigue through reduced transport of hormones and nutrients. High total protein may signal dehydration, which can cause fatigue, or immune activation that can accompany chronic inflammation or infection. Because it’s a screening marker, abnormal results often prompt checking albumin, globulins, and related tests to identify the root cause.

What factors can affect Protein, Total results, like pregnancy, posture, or recent illness?

Protein, Total can shift with hydration status (dehydration raises values; overhydration can lower them) and posture during the blood draw. Recent illness and inflammatory states can increase globulins and change total protein. Pregnancy commonly lowers total protein due to expanded blood volume (dilution). Older adults may show slight declines over time. For accurate interpretation, results should be considered alongside albumin and clinical context rather than viewed in isolation.

How is Protein, Total used to track recovery after illness, surgery, or metabolic stress?

Protein, Total can help monitor nutritional status and overall protein balance during recovery from illness, surgery, severe burns, or major metabolic stress. Improving levels may suggest better liver protein production, reduced inflammatory burden, and restored balance between protein synthesis and loss. Persistently low results can support concerns about malnutrition, poor absorption, or ongoing protein loss, while elevated values may point to dehydration or continued immune activation. Pairing with albumin and globulins improves tracking accuracy.

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