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Globulin Test

Globulin Test

January 21, 2026
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Do I need a Globulin test?

Feeling unusually tired, dealing with frequent infections, or noticing unexplained swelling? Could your immune system or liver be sending signals through your globulin levels?

Globulin is a group of proteins in your blood that supports immune function, blood clotting, and nutrient transport. When levels are off, it can point to inflammation, liver issues, or immune system concerns.

Testing your globulin gives you a vital snapshot of your immune health and liver function, helping you understand what's behind those persistent symptoms. It's the essential first step toward personalizing your health plan and making lifestyle choices that actually address what your body needs.

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Get tested with Superpower

If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone. Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.

Superpower flips that approach. We give you full insight into your body with over 100 biomarkers, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.

With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability - all in one place.

Key benefits of Globulin testing

  • Reveals your immune system's protein production and overall protein balance.
  • Spots chronic inflammation, infection, or autoimmune activity affecting your health.
  • Flags liver or kidney dysfunction that disrupts how your body makes proteins.
  • Explains fatigue, swelling, or recurring infections tied to protein imbalances.
  • Guides treatment for immune disorders, liver disease, or nutritional deficiencies.
  • Tracks response to therapy for autoimmune conditions or chronic inflammatory diseases.
  • Best interpreted with albumin and total protein to assess full protein status.

What is Globulin?

Globulin is a broad family of proteins made primarily by your liver and immune system. These proteins circulate in your blood and perform a wide range of essential tasks, from fighting infections to transporting hormones and nutrients throughout your body.

Your immune system's protein workforce

The globulin family includes antibodies (immunoglobulins), which are your body's frontline defenders against bacteria, viruses, and other invaders. It also includes transport proteins like those that carry iron, copper, thyroid hormones, and fats to where they're needed.

A window into liver and immune health

Measuring globulin gives insight into how well your liver is producing proteins and how active your immune system is. Because globulins rise during inflammation, infection, or immune activation, they serve as a useful marker of your body's response to stress or disease. Together with albumin, globulin helps paint a picture of your overall protein balance and metabolic health.

Why is Globulin important?

Globulin is a family of proteins in your blood that defend against infection, transport hormones and nutrients, and regulate inflammation and clotting. Measuring globulin reveals how well your immune system, liver, and kidneys are functioning together. Normal levels typically range from 2.0 to 3.5 g/dL, with optimal values sitting comfortably in the middle of that range.

When globulin drops too low

Low globulin often signals weakened immunity or poor protein production by the liver. You may experience frequent infections, slow wound healing, or fatigue as your body struggles to mount defenses. In severe cases, malnutrition, kidney disease that spills protein into urine, or genetic immune deficiencies can drive levels down.

When globulin climbs too high

Elevated globulin usually reflects chronic inflammation, infection, or overactive immune responses. Conditions like autoimmune disease, chronic liver disease, or blood cancers such as multiple myeloma can push levels up. You might notice persistent fatigue, unexplained fevers, or swollen lymph nodes as your immune system stays in overdrive.

The bigger immune and metabolic picture

Globulin doesn't work alone - it's interpreted alongside albumin to calculate the albumin-to-globulin ratio, which sharpens insight into liver function, immune health, and inflammatory burden. Persistent imbalances can signal evolving chronic disease, making globulin a quiet but powerful window into long-term resilience and systemic balance.

What do my Globulin results mean?

Low globulin levels

Low values usually reflect reduced immune protein production or protein loss through the kidneys or gut. This can occur with malnutrition, liver disease that impairs protein synthesis, or conditions that cause protein to leak from the body. Some people naturally run on the lower end without clinical concern, but persistently low globulin may signal weakened immune reserve or chronic inflammation affecting protein balance.

Optimal globulin levels

Being in range suggests your liver is producing adequate immune and transport proteins and your immune system is maintaining appropriate antibody levels. Optimal values typically sit in the mid to upper portion of the reference range, reflecting robust protein synthesis and a well-functioning adaptive immune response without excessive inflammation or abnormal protein production.

High globulin levels

High values usually reflect chronic immune activation, ongoing infection, or conditions that stimulate antibody production. Elevations are common with autoimmune disease, chronic viral or bacterial infections, liver disease, and certain blood cancers like multiple myeloma. The globulin fraction includes immunoglobulins (antibodies), so sustained elevation often points to prolonged immune engagement or abnormal plasma cell activity.

Factors that influence globulin

Globulin is calculated by subtracting albumin from total protein, so accuracy depends on both measurements. Dehydration can falsely elevate results, while overhydration may lower them. Chronic illness, aging, and pregnancy can shift globulin modestly. Interpretation is most meaningful alongside albumin and the albumin-to-globulin ratio.

Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.

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Frequently Asked Questions

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How it works
What should I expect during a blood draw?
  • A trained phlebotomist will guide you through the process.
  • A tourniquet is placed on your arm, the site is cleaned, and a small needle is used to collect blood into one or more tubes.
  • Results are usually ready in about a week.
  • Most people feel only a quick pinch.
  • The needle is removed, gentle pressure is applied, and a bandage is placed.
How do I prepare for a blood draw?
  • Drink plenty of water beforehand — hydration makes veins easier to find.
  • Wear loose sleeves so your arm is easy to access.
  • Follow any fasting instructions you’ve been given.
  • Let us know if you’re on medications, have fainted before, or have needle anxiety.
What should I do after my blood draw?
  • Press gently on the site for a few minutes.
  • Keep the bandage on for 4-6 hours.
  • Skip heavy lifting or strenuous exercise for the rest of the day.
  • Drink extra water to rehydrate.
  • Monitor the site for redness, swelling, or pain.
How do I book a blood draw with Superpower?

Your membership includes:

  • An annual full body test and report across 100+ biomarkers
  • A personalized action plan to optimize your biomarkers and reach your health goals
  • A dashboard to centralize your health data and track changes across a lifetime
  • Access to a health concierge for questions on your plan and help scheduling
  • Plus a marketplace of curated health products and services cheaper than amazon

Many concierge clinics charge $10k – $100k for their services, we’ve built technology to make the world’s best healthcare as accessible as possible via an all-in-one membership.

Where can I take my blood test?

Superpower is currently available in the following US states:

  • Alabama
  • Arizona
  • California
  • Colorado
  • Connecticut
  • Delaware
  • District of Columbia
  • Florida
  • Georgia
  • Idaho
  • Illinois
  • Indiana
  • Kansas
  • Maine
  • Maryland
  • Massachusetts
  • Michigan
  • Minnesota
  • Missouri
  • Montana
  • Nebraska
  • Nevada
  • New Hampshire
  • New Jersey
  • New Mexico
  • New York
  • North Carolina
  • Ohio
  • Oklahoma
  • Oregon
  • Pennsylvania
  • South Carolina
  • Tennessee
  • Texas
  • Utah
  • Vermont
  • Virginia
  • Washington
  • West Virginia
  • Wisconsin
Our testing
Does Superpower replace my primary care provider?

Superpower specializes in prevention-based testing and treatments and is not intended for emergency or immediate health issues.

While you will have a Superpower care team, your annual membership is designed to complement a primary care doctor if you have one, not replace them.

We are happy to help you share any test results with an outside provider to ensure you receive well-rounded medical care.

How fast are blood test results and how do I read them?

Your annual lab test panel takes about a week to process. We will text you as soon as they become available in your dashboard. Other types of tests may have different testing windows. The Superpower concierge is your own health assistant who helps answer your questions on your results, ensure smooth scheduling, coordination of any office-based tests, specialist referrals as needed, and navigating you to interface with your care team.

Does Superpower accept health insurance?

Superpower membership and products are all eligible for HSA/FSA funding.

We see Superpower like a gym membership for those committed to prevention and performance. Superpower is a bridge between wellness and healthcare. Health insurance traditionally focuses on reactive care whereas, at Superpower, we believe it’s never too early to start looking out for your long-term health.

What if I want more than 1 blood test per year?

Absolutely — you're not limited to just one. Your membership includes one comprehensive 100+ biomarker blood test each year, but if you'd like to track your progress more closely, you can add extra tests at any time. Each additional full-panel test costs $179. You can order as many as you'd like throughout the year.

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Frequently Asked Questions about Globulin Test

What is globulin in a blood test, and what does it measure?

Globulin is a broad family of blood plasma proteins made mainly by the liver and immune cells. A globulin test measures the “globulin fraction,” which reflects immune proteins (including immunoglobulins/antibodies), transport proteins that carry hormones, vitamins, and metals like iron and copper, and proteins involved in inflammation and clotting. It’s often used to evaluate overall protein balance and to screen for immune or liver-related issues.

Why is globulin testing important for immune system and liver health?

Globulin levels act like a window into both immune activity and liver protein production. High globulin can signal chronic inflammation, infection, or antibody overproduction, while low globulin can suggest reduced liver production, malnutrition, or protein loss through kidneys or the gut. Because these shifts can happen before obvious symptoms, globulin testing helps flag immune imbalances and liver or kidney stress early.

What is the normal globulin range, and what is considered an optimal globulin level?

Normal globulin values typically fall around 2.0 to 3.5 g/dL. “Optimal” levels generally sit in the middle of that range, suggesting balanced immune protein production and stable liver function without excessive inflammatory signaling. Interpretation still depends on your overall protein profile and clinical context, since globulin represents many different proteins rather than a single substance.

What does low globulin mean, and what conditions can cause it?

Low globulin usually reflects underproduction of immune and liver-made proteins or loss of protein through the kidneys or gut. Common causes include chronic liver disease, malnutrition, kidney disorders such as nephrotic syndrome (protein leaking into urine), and protein-losing gut conditions like inflammatory bowel disease. Low globulin may weaken immune defenses, increasing susceptibility to infections even when other labs appear normal.

What does high globulin mean, and when should I worry about elevated globulin?

High globulin most often indicates chronic immune activation - your body is producing extra antibodies or inflammation-related proteins. It can occur with autoimmune disease, chronic inflammatory states, and chronic infections (including hepatitis or HIV). Elevated globulin can also appear in plasma cell disorders such as multiple myeloma, where abnormal cells overproduce immunoglobulins. Persistent or unexplained high values should be interpreted with related protein tests.

How is globulin calculated from total protein and albumin, and why does that matter?

Globulin is commonly calculated as: total protein minus albumin. This matters because the accuracy of globulin depends on both total protein and albumin measurements. If either value is affected by hydration or lab variability, the calculated globulin can shift. Reviewing globulin alongside albumin and total protein provides a clearer picture of your full protein balance than looking at globulin alone.

What is the albumin-to-globulin (A/G) ratio, and how does it help interpret results?

The albumin-to-globulin (A/G) ratio compares albumin (a single major blood protein) to globulin (a diverse protein group). Because globulin can rise with inflammation or antibody disorders and albumin can drop with liver disease or chronic illness, the A/G ratio can sharpen interpretation. Persistent imbalance may point toward chronic liver disease, kidney dysfunction, or ongoing immune activation that warrants follow-up.

Can dehydration, overhydration, pregnancy, or aging affect globulin test results?

Yes. Dehydration can concentrate blood proteins and falsely elevate globulin, while overhydration can dilute proteins and make globulin appear low. Pregnancy, aging, and acute illness can also shift globulin dynamics because immune proteins and inflammation markers change with physiologic stress and life stage. That’s why globulin results are best interpreted in context with albumin, total protein, symptoms, and overall health status.

How can globulin testing help explain fatigue, swelling, or frequent infections when other tests look normal?

Globulin testing can reveal hidden immune or protein-balance problems that may not show up on basic screening. Low globulin can reflect reduced antibody levels or protein loss, which may contribute to frequent infections or swelling from low circulating proteins. High globulin can point to chronic inflammation or infection, often associated with fatigue, fevers, or swollen lymph nodes. Pairing globulin with albumin and total protein improves diagnostic insight.

How is globulin used to guide or monitor treatment for liver disease, autoimmune disease, or infections?

Because globulin reflects immune protein production and liver-related protein balance, tracking globulin over time can help monitor response to therapy for liver disease, immune disorders, chronic infections, and protein-losing conditions. Rising globulin may suggest ongoing inflammation or antibody overproduction, while improving values can indicate better immune-liver balance. Results are most useful when trended with albumin, total protein, and the A/G ratio.

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