Methyl-Guard Plus

Support your heart health, energy levels, and mental clarity with Methyl-Guard Plus, a targeted B-vitamin formula designed to optimize your body's natural methylation process.

December 5, 2025
Author
Superpower Science Team
Reviewed by
Julija Rabcuka
PhD Candidate at Oxford University
Creative
Jarvis Wang

Key Facts

  • Methyl-Guard Plus delivers bioactive methyl donors — compounds that support cellular processes requiring methyl group transfer, a fundamental mechanism in energy production, DNA synthesis, and neurotransmitter regulation
  • The formula combines trimethylglycine (betaine), 5-methyltetrahydrofolate (5-MTHF), and methylcobalamin — three forms already in their active, body-ready state — with supporting B vitamins for efficient methylation pathways
  • Supports whole-body methylation, the biochemical process underlying cardiovascular, cognitive, and mood-related functions

Ingredients

Riboflavin (as Riboflavin-5-Phosphate Sodium), Vitamin B6 (as Pyridoxal-5-Phosphate), Folate (as L-5-Methyltetrahydrofolate), Vitamin B12 (as Methylcobalamin), Betaine Anhydrous (Trimethylglycine), Hypromellose capsule, Calcium Citrate, Calcium Laurate.

Why We Chose This

Methylation — the transfer of methyl groups across thousands of cellular reactions — underpins energy metabolism, cardiovascular health, and brain function. Many people struggle to maintain optimal methylation capacity due to genetics, diet, or age-related changes. Methyl-Guard Plus stands out because it uses pre-activated forms of folate, B12, and betaine that bypass conversion steps, making them immediately available for methylation reactions. Research shows this combination effectively supports homocysteine metabolism and cellular methylation capacity, addressing a gap that standard B vitamins alone may not fill.

Frequently Asked Questions About Methyl-Guard Plus

What is the supporting research for the benefits of Methyl-Guard Plus?
How do I take Methyl-Guard Plus?

Take 1-3 capsules daily, adjusting based on your individual needs and your healthcare provider's guidance.

You can take it with or without food for flexible integration into your daily routine.

Can I take Methyl-Guard Plus with other supplements or medications?

Consult your healthcare provider before combining Methyl-Guard Plus with other supplements or medications, particularly methotrexate cancer therapy. The 5-MTHF in this formula can interfere with methotrexate's anti-cancer activity, though it won't affect its anti-inflammatory use for arthritis or psoriasis.

Who might benefit from taking Methyl-Guard Plus?

People with MTHFR gene mutations or aging individuals seeking cardiovascular, cognitive, and metabolic support benefit most from this formula's methylation optimization.

Women interested in estrogen metabolism and bone health support also find value in its comprehensive B vitamin and methyl donor blend.

How long does it typically take to notice effects of Methyl-Guard Plus?

Most people notice effects of Methyl-Guard Plus within 1 to 4 weeks, though some experience results within days while others need up to 4 months for full effectiveness. Individual response varies based on metabolic function, age, symptom severity, and other health factors.