Get tested with Superpower

If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone. Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.

Superpower flips that approach. We give you full insight into your body with over 100 biomarkers, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.

With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability - all in one place.

Key benefits of Systemic Inflammation Response Index (SIRI) testing

• Tracks your body's overall inflammatory burden using routine blood cell counts.
• Flags chronic inflammation linked to cardiovascular disease and metabolic syndrome risk.
• Helps explain persistent fatigue, joint pain, or unexplained symptoms tied to inflammation.
• Guides lifestyle and treatment decisions to reduce long-term disease progression.
• Monitors response to anti-inflammatory therapies or dietary interventions over time.
• Supports cancer prognosis assessment when used alongside imaging and clinical staging.
• Best interpreted with CRP, clinical symptoms, and other inflammatory markers for context.

What is Systemic Inflammation Response Index (SIRI)?

A calculated marker that captures immune system activation

The Systemic Inflammation Response Index (SIRI) is a composite biomarker calculated from three types of white blood cells: neutrophils, monocytes, and lymphocytes. It combines these immune cell counts into a single ratio that reflects the balance between pro-inflammatory and regulatory immune responses. Unlike measuring just one cell type, SIRI captures a broader picture of how your immune system is mobilizing.

What it reveals about your body's inflammatory state

SIRI reflects the intensity and character of systemic inflammation, the body-wide immune activation that occurs during infection, tissue injury, chronic disease, or stress. Neutrophils and monocytes rise when inflammation ramps up, while lymphocytes often drop during acute stress or illness.

The ratio amplifies these shifts, making SIRI sensitive to immune imbalance. Higher values suggest a more aggressive inflammatory response, which can accompany conditions ranging from acute infections to cancer and cardiovascular disease. It serves as a window into how hard your immune system is working and whether that response is proportionate or excessive.

Why is Systemic Inflammation Response Index (SIRI) important?

SIRI is a composite blood marker that captures the balance between immune activation and regulation by combining neutrophils, monocytes, and lymphocytes. It reflects how your body is managing inflammation across multiple systems, from blood vessels to metabolic organs. Values typically range from under 0.5 to above 3.0, with lower numbers indicating a calmer, more controlled immune state.

When inflammation stays quiet

Values below 0.5 suggest minimal systemic inflammation and a well-regulated immune response. This typically reflects good metabolic health, low oxidative stress, and efficient tissue repair. People in this range often experience stable energy, fewer infections, and lower cardiovascular strain.

When the immune system shifts into overdrive

Elevated SIRI, especially above 1.5 to 2.0, signals that neutrophils and monocytes are outpacing lymphocytes, a pattern seen in chronic inflammation, infection, or tissue injury. This imbalance can drive atherosclerosis, insulin resistance, and accelerated aging of organs. Symptoms may include fatigue, poor wound healing, or recurrent illness, though many people feel no immediate effects.

The long view on immune balance

SIRI connects inflammation to nearly every chronic disease, from heart disease and diabetes to cancer progression. It offers insight into how well your body manages stress, infection, and repair over time. Tracking this marker helps reveal whether silent inflammation is quietly shaping your long-term health trajectory.

What do my Systemic Inflammation Response Index (SIRI) results mean?

Low SIRI values

Low values usually reflect minimal systemic inflammation and a balanced immune response. SIRI combines neutrophils, monocytes, and lymphocytes in a way that captures the interplay between pro-inflammatory and regulatory immune cells. When SIRI is low, it suggests that inflammatory signaling is quiet and that lymphocyte populations, which help modulate and resolve inflammation, are relatively preserved. This pattern is typical in healthy individuals without active infection, autoimmune activity, or tissue injury.

Optimal SIRI values

Being in range suggests that your immune system is maintaining equilibrium between activation and regulation. SIRI does not have a single universal reference range, but lower values within the normal spectrum generally reflect better metabolic and cardiovascular health. Optimal SIRI tends to sit toward the lower end, indicating controlled inflammation and intact immune coordination.

High SIRI values

High values usually reflect systemic inflammation driven by an elevated neutrophil and monocyte response relative to lymphocytes. This pattern is seen in acute infections, chronic inflammatory conditions, metabolic stress, and malignancy. Elevated SIRI has been associated with worse outcomes in cardiovascular disease, cancer, and critical illness, as it signals ongoing immune activation and potential tissue damage.

Notes on interpretation

SIRI can be influenced by acute illness, surgery, trauma, chronic disease, and certain medications like corticosteroids. It is most informative when interpreted alongside clinical context and other inflammatory markers.