Get tested with Superpower

If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone. Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.

Superpower flips that approach. We give you full insight into your body with over 100 biomarkers, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.

With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability - all in one place.

Key benefits of Neutrophil-to-Lymphocyte & Platelet Ratio (NLPR) testing

• Flags systemic inflammation and immune imbalance using routine blood cell counts.
• Spots early cardiovascular risk before symptoms appear in healthy adults.
• Guides cancer prognosis and tracks treatment response in oncology care.
• Clarifies infection severity and helps predict outcomes in acute illness.
• Tracks chronic inflammatory conditions like autoimmune disease and metabolic syndrome.
• Supports surgical risk assessment by identifying patients at higher complication risk.
• Best interpreted alongside complete blood count, symptoms, and clinical history.

What is Neutrophil-to-Lymphocyte & Platelet Ratio (NLPR)?

NLPR is a composite blood marker that combines three key immune and clotting cell types: neutrophils, lymphocytes, and platelets. It's calculated by multiplying the neutrophil-to-lymphocyte ratio (NLR) by the platelet count. This creates a single number that captures both inflammatory activity and clotting potential in one snapshot.

A window into inflammation and clotting balance

NLPR reflects the interplay between your body's inflammatory response and its ability to form blood clots. Neutrophils rise during acute stress or infection, lymphocytes coordinate adaptive immunity, and platelets enable clotting and wound repair. When combined mathematically, these three cell populations reveal patterns that neither marker shows alone.

Why combine these specific cells?

This ratio emerged from research showing that inflammation and clotting often move together in chronic disease. Elevated neutrophils with rising platelets suggest a pro-inflammatory, pro-thrombotic state. Lower lymphocytes in this context may signal immune exhaustion or suppression. NLPR integrates these signals into a single metric that researchers use to assess disease severity and prognosis in conditions ranging from cardiovascular disease to cancer.

Why is Neutrophil-to-Lymphocyte & Platelet Ratio (NLPR) important?

NLPR combines two immune signals - neutrophils and platelets versus lymphocytes - into a single index that reflects how your body balances inflammation, clotting, and immune defense. It captures the interplay between acute stress responses and adaptive immunity, offering insight into systemic inflammation, infection severity, and thrombotic risk. Lower values generally suggest balanced immune tone, while higher values point to heightened inflammatory or prothrombotic states.

When the ratio stays low

Values below typical ranges may indicate robust lymphocyte activity or reduced neutrophil and platelet activation. This pattern can appear in well-controlled chronic conditions or after recovery from acute illness. In some cases, it reflects bone marrow suppression or autoimmune states where lymphocytes dominate, potentially signaling fatigue or recurrent infections.

When the ratio climbs high

Elevated NLPR emerges during acute infections, severe inflammation, or thrombotic events, as neutrophils and platelets surge while lymphocytes drop. This shift is common in sepsis, cardiovascular events, and advanced cancers. Women during pregnancy may show modest increases due to physiologic immune remodeling, but extreme elevations warrant investigation.

The bigger immune and vascular picture

NLPR bridges innate immunity, adaptive defense, and coagulation pathways. Persistently high values correlate with worse outcomes in critical illness, cardiovascular disease, and malignancy, reflecting systemic dysregulation. Monitoring trends helps gauge disease severity and recovery trajectory across multiple organ systems.

What do my Neutrophil-to-Lymphocyte & Platelet Ratio (NLPR) results mean?

Low NLPR values

Low values usually reflect a relatively lower neutrophil count, higher lymphocyte count, or higher platelet count in combination. This pattern may occur during recovery from acute infection, in certain chronic viral states, or with bone marrow conditions that favor lymphocyte or platelet production. It can also appear in autoimmune states where lymphocyte populations expand. Low NLPR is less commonly discussed in clinical literature and typically carries less prognostic weight than elevated values.

Optimal NLPR values

Being in range suggests balanced immune cell populations and platelet production, reflecting stable inflammatory tone and clotting capacity. NLPR is a composite marker, so optimal values depend on the underlying health of myeloid and lymphoid lineages as well as megakaryocyte function. There is no universally agreed reference range, as NLPR is primarily studied in research and specific disease contexts rather than routine screening.

High NLPR values

High values usually reflect systemic inflammation, immune activation, or thrombocytosis. Elevated NLPR is seen in acute infection, chronic inflammatory states, cardiovascular disease, malignancy, and metabolic syndrome. It integrates signals from neutrophil-driven inflammation, lymphocyte suppression, and platelet reactivity, making it a marker of multi-system stress and poorer prognosis in critical illness and cancer.

Notes on interpretation

NLPR interpretation depends on clinical context, including acute illness, chronic disease, medications, and laboratory variability. It is not standardized across labs and is used mainly in research and prognostic models.