Do I need an Estimated Glomerular Filtration Rate (eGFR) test?
Feeling unusually fatigued, noticing swelling in your legs, or concerned about changes in your urination? Could your kidneys be struggling, and might an eGFR test reveal what's happening?
eGFR measures how well your kidneys filter waste from your blood. It's one of the most reliable indicators of kidney function and can catch problems early, often before symptoms worsen.
Testing your eGFR gives you a quick snapshot of your kidney health, empowering you to personalize your diet, medications, and lifestyle choices based on what your body actually needs. It's the essential first step to address fatigue, swelling, and other concerns at their root.
Get tested with Superpower
If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone. Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.
Superpower flips that approach. We give you full insight into your body with over 100 biomarkers, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.
With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability - all in one place.
Key benefits of Estimated Glomerular Filtration Rate (eGFR) testing
- Measures how well your kidneys filter waste from your blood.
- Spots early kidney damage before you feel any symptoms.
- Guides medication dosing to protect your kidneys from harm.
- Tracks kidney function over time if you have diabetes or hypertension.
- Flags risk for heart disease, as kidney health affects cardiovascular outcomes.
- Clarifies fatigue, swelling, or changes in urination that may signal decline.
- Best interpreted with creatinine, urinalysis, and your complete clinical picture.
What is Estimated Glomerular Filtration Rate (eGFR)?
eGFR is a calculated measure of how efficiently your kidneys filter waste from your blood. It estimates the volume of blood your glomeruli (tiny filtering units inside the kidneys) can clean each minute. This number is derived from a blood test, typically using creatinine levels along with factors like age, sex, and sometimes race.
Your kidneys are your body's filtration system
Each kidney contains about a million glomeruli that act as microscopic sieves. They allow waste products and excess fluid to pass into urine while keeping essential proteins and blood cells in circulation.
eGFR reveals kidney performance in real time
When kidney function declines, fewer glomeruli work effectively, and the filtration rate drops. eGFR captures this change, making it the most widely used indicator of overall kidney health.
A single number that tells a big story
Because direct measurement of filtration is impractical, eGFR offers a reliable, non-invasive snapshot. It helps identify chronic kidney disease early, guide treatment decisions, and monitor how well your kidneys are keeping up with the body's daily demands.
Why is Estimated Glomerular Filtration Rate (eGFR) important?
eGFR measures how efficiently your kidneys filter waste and excess fluid from your blood each minute. It's the single most important indicator of kidney function and reveals whether your filtration system is keeping pace with your body's metabolic demands. Normal values range from 90 to over 120 mL/min/1.73m², with optimal function sitting comfortably above 90.
When filtration slows, waste accumulates
Values below 60 signal chronic kidney disease, meaning your nephrons - the kidney's microscopic filtering units - are damaged or dying. As eGFR drops, toxins like urea and creatinine build up, triggering fatigue, nausea, swelling in the ankles, and brain fog. Blood pressure rises because the kidneys can't regulate fluid and sodium properly. Women, older adults, and people with diabetes or hypertension are at higher risk.
High values usually reflect robust kidney reserve
An eGFR above 120 is typically seen in young, healthy individuals or during pregnancy, when kidneys work harder to support increased blood volume. It rarely signals disease but can appear transiently with high protein intake or vigorous hydration.
Kidney health shapes your entire metabolic future
Because the kidneys regulate electrolytes, blood pressure, red blood cell production, and bone mineralization, declining eGFR affects the heart, brain, bones, and immune system. Early detection allows time to slow progression and protect these interconnected systems from irreversible harm.
What do my Estimated Glomerular Filtration Rate (eGFR) results mean?
Low eGFR values
Low values usually reflect reduced kidney filtering capacity, meaning the kidneys are clearing waste products from the blood less efficiently than expected. This can occur with chronic kidney disease, acute kidney injury, severe dehydration, or conditions that reduce blood flow to the kidneys such as heart failure or shock. As eGFR declines, waste products like creatinine and urea accumulate, which can affect fluid balance, blood pressure regulation, electrolyte stability, and red blood cell production. eGFR naturally declines with age, so lower values in older adults may reflect normal aging rather than disease. Women typically have slightly lower eGFR than men due to differences in muscle mass.
Optimal eGFR values
Being in range suggests your kidneys are filtering blood effectively and maintaining stable waste clearance, fluid balance, and electrolyte homeostasis. Most labs define normal as above 90, though values between 60 and 90 are often considered acceptable, especially in older adults. Optimal function typically sits in the higher portion of the normal range in younger, healthy individuals.
High eGFR values
High values usually reflect hyperfiltration, a state where the kidneys are working harder than normal to filter blood. This can occur in early diabetes, pregnancy, high protein intake, or after loss of one kidney when the remaining kidney compensates by increasing its filtration rate.
Notes on interpretation
eGFR is calculated from serum creatinine, age, sex, and sometimes race, so accuracy depends on stable muscle mass and proper equation selection.
Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.

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