Key Facts
- 5-MTHF is the active, methylated form of folate that your body can use immediately without additional conversion steps
- Supports the methylation cycle, a fundamental biochemical process that influences heart health, brain function, energy production, and bone strength
- Particularly valuable for the roughly 60% of adults with an MTHFR gene variation that impairs folate metabolism
- Helps maintain healthy homocysteine levels and supports neurotransmitter production for mood and cognitive function
Ingredients
5-methyltetrahydrofolate (8.3 mg DFE per serving), vegetarian capsule.
Why We Chose This
Most folate supplements require your body to convert them into a usable form, a step that doesn't work well for people with MTHFR variations. 5-MTHF bypasses this bottleneck entirely, delivering folate your cells can actually use. This matters because folate fuels methylation, a metabolic process that touches nearly every system in your body—from how your brain produces serotonin and dopamine to how your liver processes toxins. The research-backed formulation here provides meaningful support without unnecessary additives, making it a straightforward choice for anyone looking to optimize this foundational biochemical pathway.
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