What are Hyperuricemia biomarkers

Hyperuricemia biomarkers tell you how much uric acid your body is carrying and how well you are clearing it. The central marker is serum urate—the circulating form of uric acid made when the body breaks down purines from your own cells and food (purine catabolism via xanthine oxidoreductase in liver and intestine). This level reflects a balance between production and disposal: the kidneys and, to a lesser extent, the gut move urate out of the body using specific transporters (URAT1/SLC22A12, GLUT9/SLC2A9, ABCG2). Complementary measures, such as uric acid in urine and its fractional excretion, indicate how the kidneys are handling that load. Together, these biomarkers signal the biological pressure for monosodium urate crystals to form in joints, tendons, and kidneys—the step that can trigger gouty inflammation and stone formation. Because hyperuricemia is often silent until crystals appear, testing brings the process into view early, helps clarify whether excess comes from overproduction or under-excretion, and anchors simple, targeted strategies to lower the body’s urate burden.

Why is blood testing for Hyperuricemia important?

• Check uric acid to detect hyperuricemia driving gout and kidney stones.
• Spot early uric acid buildup before painful gout flares.
• Clarify gout versus other arthritis when combined with joint exam or crystal testing.
• Guide treatment using treat-to-target goals: <6 mg/dL; <5 with visible deposits.
• Track response and adherence by trending levels after starting uric-acid–lowering therapy.
• Protect kidney health by flagging risk for uric acid stones and damage.
• Support pregnancy care by marking high levels linked to preeclampsia risk assessment.
• Interpret results with kidney function (creatinine/eGFR) and symptoms; levels can normalize during flares.

What insights will I get?

Hyperuricemia blood testing provides insight into how your body manages purine metabolism, which is closely tied to energy production, cardiovascular health, kidney function, and inflammation. At Superpower, we assess this system by measuring Uric Acid, the key biomarker for hyperuricemia. Understanding your uric acid level helps reveal how well your body is balancing the breakdown and elimination of purines, which are natural compounds found in your cells and in many foods.

Uric acid is a waste product formed when your body metabolizes purines. Normally, uric acid dissolves in the blood, passes through the kidneys, and is excreted in urine. Hyperuricemia occurs when uric acid builds up in the blood, either because the body produces too much or the kidneys do not remove enough. Elevated uric acid is the defining feature of hyperuricemia and is central to its diagnosis.

Stable uric acid levels support healthy joint, kidney, and vascular function. When uric acid remains within a healthy range, it helps maintain the stability of connective tissues and blood vessels, and reduces the risk of crystal formation that can trigger inflammation. Persistent elevations can disrupt these systems, increasing the risk for gout, kidney stones, and possibly contributing to cardiovascular and metabolic disturbances.

Interpretation of uric acid results depends on several factors. Levels can vary with age, sex, genetics, kidney function, and certain medications. Pregnancy, acute illness, and recent dietary changes can also influence results. Laboratory methods may differ, so reference ranges can vary between testing sites.