It checks your immune system’s reaction to gluten and its impact on your gut and blood. Core celiac serology measures antibodies against tissue transglutaminase (tTG-IgA) and often total IgA; some panels add EMA or DGP. These show autoimmune activity in the small intestine. To assess system effects, Superpower also tests Hemoglobin, Ferritin, Folate, B12, and ESR. Low blood counts and nutrients point to malabsorption; a raised ESR signals inflammation. Together, these results map both the trigger (autoantibodies) and the consequences (anemia, nutrient deficits, inflammation).

It detects an autoimmune reaction that damages the small intestine, often before classic digestive symptoms appear. Early detection prevents ongoing malabsorption that can cause anemia, low bone density, neuropathy, infertility, and fatigue. Antibody tests (tTG-IgA, EMA, DGP) reveal immune activation to gluten; total IgA checks for IgA deficiency that can mask results. Superpower’s Hemoglobin, Ferritin, Folate, B12, and ESR show how far the process has affected oxygen carrying capacity, iron and vitamin stores, and systemic inflammation.

Yes. With Superpower, our team member can organize a professional blood draw in your home for convenient, high-quality sampling.

Screen once if you have symptoms or risk. If your celiac serology is positive, repeat testing tracks antibody fall with treatment. If diagnosed, monitor tTG-IgA and nutrition status every 3–6 months until normalized, then yearly. Superpower’s Hemoglobin, Ferritin, Folate, B12, and ESR help confirm recovery from malabsorption and inflammation and catch relapses early. If your first test is negative but suspicion stays high, retest while eating gluten, or use alternative assays if IgA is low.

Gluten restriction quickly lowers celiac antibodies and can hide disease. IgA deficiency can falsely lower tTG-IgA. Intercurrent infections, liver disease, and other autoimmune conditions can alter antibody results. Iron infusions, recent transfusion, and acute inflammation raise Ferritin independent of iron stores. Supplements and injections raise Folate and B12; metformin and acid suppressants can lower B12. Dehydration, high altitude, menstruation, and pregnancy shift Hemoglobin; systemic inflammation, anemia, and pregnancy elevate ESR. Lab timing, recent strenuous exercise, and alcohol can add variability.

No special fasting is required. Be well hydrated and avoid strenuous exercise right before your draw. If possible, skip high‑dose iron, folate, or B12 supplements the morning of testing to avoid short‑term spikes that don’t reflect body stores; tell us about recent iron infusions or transfusions. ESR does not need fasting. If you are also doing celiac antibody testing, remain on a normal gluten‑containing diet beforehand so immune markers are reliable. Take usual prescribed medicines unless your clinician advises otherwise.

Yes. Going gluten‑free lowers celiac antibodies and allows gut healing, which normalizes Hemoglobin, Ferritin, Folate, and B12 over time. Overall inflammation trends with ESR; infections and chronic inflammatory states can raise it. Dietary intake and absorption drive Folate and B12; iron intake and losses shape Ferritin and Hemoglobin. Hydration status, altitude, and recent intense exercise can shift Hemoglobin transiently. Alcohol use and some medications affect B12 and Folate. These markers reflect physiology in motion, not just a single point in time.

Positive celiac antibodies (e.g., tTG‑IgA) indicate an immune response to gluten; higher titers suggest active intestinal injury. A low total IgA can make IgA‑based tests falsely negative. Low Hemoglobin with low Ferritin points to iron deficiency from malabsorption; low Folate or B12 indicates impaired nutrient uptake. A raised ESR signals systemic inflammation but is non‑specific. After diagnosis, falling antibody levels and rising iron and vitamin stores show healing; persistent abnormalities suggest ongoing immune activation, continued exposure, or another condition affecting absorption.