Get tested with Superpower

If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone. Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.

Superpower flips that approach. We give you full insight into your body with over 100 biomarkers, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.

With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability - all in one place.

Key benefits of Testosterone / Estradiol (T:E2) testing

• Shows the balance between two key hormones that regulate metabolism and mood.
• Flags estrogen dominance that may drive weight gain or low energy in men.
• Explains stubborn symptoms like brain fog, fatigue, or reduced libido.
• Guides aromatase management to optimize testosterone therapy outcomes.
• Protects bone health by identifying imbalances that accelerate bone loss.
• Tracks how lifestyle, supplements, or medications shift your hormonal balance over time.
• Best interpreted alongside total and free testosterone plus clinical symptoms.

What is Testosterone / Estradiol (T:E2)?

The testosterone to estradiol ratio (T:E2) is a calculated biomarker that compares the levels of two key sex hormones in your blood. Testosterone is the primary male sex hormone, produced mainly in the testes in men and in smaller amounts by the ovaries and adrenal glands in women. Estradiol is the most potent form of estrogen, synthesized from testosterone by an enzyme called aromatase, which is active in fat tissue, the brain, and reproductive organs.

A window into hormonal balance

This ratio reflects the dynamic equilibrium between androgenic (masculinizing) and estrogenic (feminizing) signals in your body. In men, a declining T:E2 ratio often signals increased aromatase activity or reduced testosterone production, which can influence body composition, mood, and metabolic health.

Why the balance matters

The T:E2 ratio helps reveal whether your body is converting too much testosterone into estradiol or whether testosterone levels are falling independently. Both sexes rely on balanced levels of these hormones for bone strength, cardiovascular function, libido, and cognitive performance.

Why is Testosterone / Estradiol (T:E2) important?

The testosterone-to-estradiol ratio reflects how your body balances these two powerful sex hormones, which together regulate metabolism, body composition, mood, libido, bone density, and cardiovascular health. While testosterone is often labeled the male hormone and estradiol the female one, both sexes produce and need both. The ratio matters because testosterone can convert into estradiol through an enzyme called aromatase, and when this conversion runs too high or too low, whole-body systems shift out of balance.

When the ratio tips toward estradiol

A lower ratio means estradiol is relatively high compared to testosterone. In men, this often appears as increased abdominal fat, breast tissue growth (gynecomastia), reduced muscle mass, low libido, and fatigue. In women, it may worsen estrogen-dominant conditions like heavy periods or breast tenderness. Excess aromatase activity, obesity, liver dysfunction, or certain medications can drive this pattern.

When testosterone dominates

A higher ratio suggests testosterone is elevated relative to estradiol. In women, this can signal polycystic ovary syndrome, with irregular cycles, acne, and excess body hair. In men, very high ratios are less common but may reflect low aromatase activity or estradiol deficiency, which can impair bone health and lipid metabolism over time.

The metabolic and longevity connection

This ratio integrates with insulin sensitivity, inflammation, and cardiovascular risk. Chronic imbalance affects bone remodeling, cognitive function, and sexual health across the lifespan, making it a window into hormonal aging and metabolic resilience.

What do my Testosterone / Estradiol (T:E2) results mean?

Low T:E2 ratio

Low values usually reflect relatively high estradiol activity compared to testosterone, which can occur when testosterone declines or when estradiol rises or is not efficiently metabolized. In men, this pattern is common with aging, obesity, or aromatase upregulation in adipose tissue. It may accompany changes in body composition, mood, libido, and metabolic health. In women, interpretation depends heavily on cycle phase and menopausal status, as estradiol naturally dominates during the follicular phase and declines after menopause.

Optimal T:E2 ratio

Being in range suggests balanced androgen and estrogen signaling, which supports stable mood, metabolic function, bone health, and reproductive physiology. Optimal ratios differ by sex and life stage. In men, higher ratios are generally favorable for lean mass and metabolic tone. In premenopausal women, the ratio fluctuates across the menstrual cycle, and no single target applies universally.

High T:E2 ratio

High values usually reflect elevated testosterone relative to estradiol, seen in conditions like polycystic ovary syndrome in women or with exogenous androgen use. In men, it may occur with low aromatase activity or estradiol deficiency, which can affect bone density and lipid metabolism despite adequate testosterone.

Factors that influence T:E2 ratio

This ratio is shaped by body composition, liver function, aromatase activity, age, and hormonal medications. Assay variability and timing relative to menstrual cycle or hormone therapy significantly affect interpretation.