Get tested with Superpower

If you’ve been postponing blood testing for years or feel frustrated by doctor appointments and limited lab panels, you are not alone. Standard healthcare is often reactive, focusing on testing only after symptoms appear or leaving patients in the dark.

Superpower flips that approach. We give you full insight into your body with over 100 biomarkers, personalized action plans, long-term tracking, and answers to your questions, so you can stay ahead of any health issues.

With physician-reviewed results, CLIA-certified labs, and the option for at-home blood draws, Superpower is designed for people who want clarity, convenience, and real accountability - all in one place.

Key benefits of Systemic Immune-Inflammation Index (SII) testing

• Reveals your body's balance between inflammation and immune response in one number.
• Flags chronic inflammation linked to heart disease, diabetes, and autoimmune conditions early.
• Helps explain fatigue, joint pain, or recurring infections when standard tests look normal.
• Tracks how lifestyle changes or treatments reduce inflammatory burden over time.
• Guides decisions about anti-inflammatory therapies or immune-supporting interventions.
• Identifies elevated cardiovascular risk beyond cholesterol and blood pressure alone.
• Best interpreted alongside CRP, CBC with differential, and your symptom pattern.

What is Systemic Immune-Inflammation Index (SII)?

The Systemic Immune-Inflammation Index is a calculated marker that combines three types of white blood cells: neutrophils, lymphocytes, and platelets. It was developed to capture the balance between inflammation and immune regulation in a single number. Unlike measuring just one cell type, SII reflects how these three components interact to shape your body's inflammatory state.

A snapshot of immune balance

SII provides a window into the ongoing conversation between your innate immune system (represented by neutrophils and platelets) and your adaptive immune system (represented by lymphocytes). When inflammation rises, neutrophils and platelets typically increase while lymphocytes may decrease, shifting the index upward.

Why three cell types matter

Each component tells part of the story. Neutrophils rush to sites of tissue damage or infection. Platelets help clot blood but also release inflammatory signals. Lymphocytes coordinate targeted immune responses and help resolve inflammation.

Beyond simple inflammation markers

By integrating all three, SII captures immune-inflammatory dynamics that single markers might miss. It reflects whether your body is leaning toward active inflammation or immune balance.

Why is Systemic Immune-Inflammation Index (SII) important?

The Systemic Immune-Inflammation Index integrates three white blood cell types - platelets, neutrophils, and lymphocytes - into a single ratio that reflects how your immune system balances inflammation and defense. It captures the interplay between clotting, acute immune response, and adaptive immunity, offering insight into chronic inflammation, cardiovascular strain, and cancer-related immune shifts. Reference ranges typically fall between 200 and 800, with lower values generally signaling better immune balance.

When the index runs low

Values below the typical range suggest a well-regulated immune environment with minimal systemic inflammation. This often correlates with lower cardiovascular risk and reduced oxidic stress across tissues. However, extremely low readings may reflect immune suppression, particularly in people undergoing chemotherapy or living with autoimmune conditions on immunosuppressive therapy.

When the index climbs high

Elevated SII points to heightened neutrophil activity and platelet activation alongside relative lymphocyte depletion, a pattern seen in chronic stress, metabolic syndrome, and active malignancy. High values are linked to increased risk of heart attack, stroke, and poor cancer prognosis. Women during pregnancy may show modest elevations due to physiologic immune shifts, while older adults often trend higher due to inflammaging.

The bigger immune picture

SII connects inflammation, clotting, and immune surveillance into one metric, making it a window into systemic wear and long-term disease risk. Persistently high values signal that multiple organ systems - vascular, metabolic, and immune - are under strain, underscoring the importance of addressing root inflammatory drivers.

What do my Systemic Immune-Inflammation Index (SII) results mean?

Low SII values

Low values usually reflect reduced systemic inflammatory activity and a balanced immune response. This pattern suggests that neutrophils, lymphocytes, and platelets are circulating in proportions that favor immune surveillance without excessive activation. Very low values are uncommon but may occur with bone marrow suppression or certain immunodeficiency states.

Optimal SII values

Being in range suggests your innate and adaptive immune systems are functioning in a coordinated manner without chronic overactivation. The SII integrates three cell types involved in inflammation and clotting, so normal values indicate stable immune-inflammatory tone. Optimal levels tend to sit in the lower half of the reference range, reflecting minimal background inflammation.

High SII values

High values usually reflect heightened systemic inflammation driven by an imbalance among neutrophils, platelets, and lymphocytes. This pattern is common during acute infections, chronic inflammatory conditions, metabolic stress, and malignancy. Elevated SII indicates that pro-inflammatory pathways are dominant, which can affect vascular health, tissue repair, and immune regulation. Values tend to rise with age and are often higher in men than women.

Factors that influence SII

The SII is calculated from a complete blood count, so anything affecting white blood cell or platelet production influences the result. Acute illness, surgery, smoking, obesity, and certain medications can elevate the index. Reference ranges vary by laboratory and population studied.