Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
A derived biomarker is a value that is calculated from other directly measured biomarkers rather than being measured directly in the lab.
Key benefits of Diethylphosphate (DEP) testing
- Organophosphate pesticide class exposure tracking
- agricultural and residential pesticide burden assessment
What is Diethylphosphate (DEP)?
Diethylphosphate (DEP) is a non-specific urinary metabolite indicating exposure to diethyl-type organophosphate (OP) pesticides - a class used extensively in agriculture and some residential pest control. Measured via LC-MS/MS.
Why is Diethylphosphate (DEP) important?
Organophosphates inhibit acetylcholinesterase, an enzyme critical to normal nerve function. Even low-level chronic exposure has been associated in research with potential neurotoxic effects. DEP reflects recent personal exposure to this pesticide class from dietary or environmental sources.
What insights will I get?
Your DEP level may reflect dietary exposure through conventionally grown produce, residential pesticide use, or occupational agricultural contact. Comparing results before and after shifting toward an organic diet may reveal measurable differences. Elevated levels may inform produce sourcing decisions.
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