Method: Shotgun metagenomic sequencing (CLIA 21D2062464); not cleared or approved by the FDA. Results reflect relative microbial abundance for wellness education purposes. Not intended to diagnose or treat disease and not a substitute for clinical consultation. Microbial associations are based on emerging scientific research and may change over time. Derived from laboratory results. This score or index is not an FDA-cleared test. It aids clinician-directed assessment and is not a stand-alone diagnosis.
A derived biomarker is a value that is calculated from other directly measured biomarkers rather than being measured directly in the lab.
Key benefits of Beta-glucuronidase capacity testing
- Estrogen and xenobiotic metabolism microbiome capacity tracking
- estrobolome assessment
What is Beta-glucuronidase capacity?
Beta-glucuronidase capacity estimates the aggregate activity of gut bacteria encoding the beta-glucuronidase enzyme (GUS). This enzyme deconjugates glucuronidated compounds in the gut - including estrogens and some drugs and environmental toxins - potentially allowing reabsorption.
Why is Beta-glucuronidase capacity important?
Beta-glucuronidase activity is a key function of the gut estrobolome - the collection of gut microbes that metabolize estrogens. High GUS activity may increase intestinal reabsorption of conjugated estrogens, potentially affecting estrogen cycling. It may also affect metabolism of certain drugs and environmental xenobiotics.
What insights will I get?
Your beta-glucuronidase capacity may be relevant for understanding gut microbiome contributions to estrogen metabolism and xenobiotic recycling. Members with hormonal health goals or those monitoring environmental toxin clearance may find this metric particularly useful to track.
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