Key Benefits

• Check your body’s salt–water balance for healthy nerve, muscle, and brain function.
• Spot low or high sodium that drives headaches, confusion, cramps, or nausea.
• Clarify dizziness, weakness, or seizures by linking symptoms to sodium shifts.
• Guide fluids and diuretics in heart, kidney, or liver conditions safely.
• Flag medication effects that lower or raise sodium, preventing adverse events.
• Uncover hormone-related water problems, including antidiuretic hormone disorders or diabetes insipidus.
• Protect brain health by catching dangerous levels that increase seizure or coma risk.
• Best interpreted with potassium, chloride, creatinine, glucose, and your symptoms.

What is a Sodium blood test?

Blood sodium testing measures the amount of sodium, a charged mineral (electrolyte), in the liquid part of your blood. Sodium comes from your diet—mainly table salt (sodium chloride)—and after absorption in the gut it lives mostly in the fluid outside cells (extracellular fluid). Its level is tightly managed by the kidneys under the direction of water- and salt-sensing hormones such as aldosterone and antidiuretic hormone (vasopressin), which respond to changes in concentration and volume (osmolality and volume status).

Sodium’s main job is to keep water balanced and electricity flowing. It sets the concentration of the fluid around cells, helping control hydration, blood pressure, and how much water the body holds (extracellular volume and tonicity). It also helps generate the electrical signals that let nerves fire and muscles contract (membrane potential and action potentials). A blood sodium result, therefore, is a concise readout of your body’s water-salt balance and the coordination between brain, hormones, and kidneys that maintains it (osmoregulation and the renin–angiotensin–aldosterone system).

Why is a Sodium blood test important?

Sodium is the body’s main extracellular electrolyte. It sets your blood’s osmolality, pulling water where it needs to go, and it helps nerves fire and muscles contract. A sodium blood test is a systems check on hydration, blood volume and pressure, kidney function, and the brain’s water-regulating hormones.

Most laboratories consider about 135–145 normal. Health typically lives near the middle, stable from day to day; rapid shifts matter more than tiny, steady differences.

When sodium is below range (hyponatremia), there is too much water relative to salt. Water moves into cells—especially brain cells—causing swelling. People may notice nausea, headache, fogginess, unsteady gait, and in more severe cases confusion, seizures, or coma. It often reflects excess vasopressin (ADH) signaling, diuretics, heart/liver/kidney disease, adrenal or thyroid disorders, or endurance overhydration. Older adults and women (particularly on thiazide diuretics) are more prone to symptomatic low sodium. Pregnancy runs slightly lower baseline sodium. Chronic low levels link to falls, fractures, and attention and balance problems.

When sodium is above range (hypernatremia), there is too little body water. Cells shrink, the brain is vulnerable, and symptoms include intense thirst, dry mouth, weakness, agitation, confusion, and seizures; acute rises can risk intracranial bleeding. Common drivers are dehydration, impaired thirst, limited water access, or diabetes insipidus.

Big picture: sodium integrates the kidneys with the pituitary and adrenal axes (vasopressin and renin–angiotensin–aldosterone). It interacts with glucose and overall fluid balance. Persistent abnormalities signal higher risks of hospitalization, cognitive issues, fractures, and mortality, making this test a core indicator of whole-body homeostasis.

What insights will I get?

What a Sodium blood test tells you

A sodium blood test measures the main positively charged mineral in blood outside cells. Sodium is the chief driver of plasma osmolality, so it governs where water sits in the body, blood volume and pressure, and the electrical signals that power nerves and muscles. Because water balance is hormonally regulated, sodium reflects integrated kidney, adrenal (aldosterone), and brain (antidiuretic hormone/vasopressin) control that underpins energy, cognition, and cardiovascular stability.

Low values usually reflect too much water relative to sodium (dilution), not a true sodium deficit. This occurs with excess vasopressin release (SIADH), diuretic use, heart failure, liver disease, kidney disease, too little adrenal hormone (adrenal insufficiency), or too little thyroid hormone (hypothyroidism). The brain is sensitive to low osmolality, so fatigue, headache, confusion, or muscle cramps can appear. Older adults are more susceptible; pregnancy runs slightly lower due to a reset osmostat and plasma expansion.

Being in range suggests balanced water–electrolyte homeostasis, effective kidney concentrating ability, and appropriate adrenal and vasopressin signaling. That supports stable blood pressure, steady cognition, and reliable neuromuscular function. Clinically, values near the middle of the laboratory reference window are often interpreted as most stable.

High values usually reflect too little water relative to sodium (dehydration) from insufficient intake, fluid losses, or impaired vasopressin action such as diabetes insipidus. Osmotic diuresis and severe gastrointestinal losses can contribute. Thirst, irritability, or lethargy may occur; infants and older adults are at higher risk due to limited thirst or access to fluids.

Notes: Acute illness, IV fluids, and many drugs (diuretics, SSRIs, carbamazepine, desmopressin) shift sodium. Marked high blood sugar lowers measured sodium by water shifts. Very high blood fats or proteins can cause pseudohyponatremia with some assays. Pregnancy lowers the set-point slightly.