Key Benefits

• Measure DHEA-S to gauge adrenal androgen output and hormone balance.
• Clarify androgen source—adrenal versus ovarian—when levels or symptoms suggest excess.
• Explain acne, hirsutism, or scalp hair loss by identifying adrenal-driven imbalance.
• Flag very high levels that may signal an adrenal tumor needing evaluation.
• Protect fertility by spotting androgen excess that disrupts ovulation and menstrual regularity.
• Spot low adrenal output that may support a diagnosis of adrenal insufficiency.
• Track androgen trends during treatment for hyperandrogenism or adrenal disorders.
• Best interpreted with testosterone, 17-hydroxyprogesterone, age- and sex-specific ranges, and symptoms.

What is a DHEA Sulfate (DHEA-S) blood test?

DHEA-S is the sulfated, storage form of the hormone DHEA made mainly by the adrenal glands. In blood, it appears as a stable pool that the body can draw on. Most DHEA-S comes from the adrenal cortex (zona reticularis), with smaller contributions from the ovaries or testes and the brain. “Sulfation” makes DHEA water‑soluble and long‑lasting in circulation, so DHEA-S changes slowly compared with other hormones (dehydroepiandrosterone sulfate).

Its importance is as a building block for sex hormones and a readout of adrenal androgen output. Tissues convert DHEA-S locally into androgens and estrogens as needed (prohormone to androgens/estrogens), supporting functions like hair growth, skin oil production, bone and muscle maintenance, and aspects of mood and libido. Because production is stimulated by the pituitary’s ACTH signal, blood testing for DHEA-S reflects the adrenal gland’s capacity to make androgens (ACTH-driven adrenal androgen status). Measuring DHEA-S provides a steady, day‑to‑day view of this system, in contrast to the quicker ups and downs seen with many other hormones.

Why is a DHEA Sulfate (DHEA-S) blood test important?

DHEA-S is the sulfated, storage form of DHEA made mostly by the adrenal glands. With a long half-life and minimal daily fluctuation, it’s a stable readout of adrenal androgen output that influences skin and hair, libido and mood, bone and muscle maintenance, insulin sensitivity, and reproductive signaling.

Reference ranges are age- and sex-specific, peaking in late adolescence/early adulthood and steadily declining with age. In general, healthy individuals sit in the mid range for their age bracket; interpretation works best alongside cortisol, testosterone/androstenedione, and gonadotropins.

When values are low, they reflect reduced adrenal androgen production—from aging, pituitary suppression, or adrenal disease. People may notice low energy, decreased libido, dry skin, low mood, and reduced bone and muscle support. In women, sexual interest and vaginal lubrication can drop; in men, effects are often subtler because testes supply most testosterone. In teens, low levels can delay pubic/axillary hair. During pregnancy, maternal DHEA-S often runs lower due to placental conversion.

When values are high, the adrenal glands are overproducing androgens. This can drive oily skin, acne, scalp hair thinning, and excess facial/body hair; women may have irregular periods and ovulatory issues, including patterns seen in PCOS. In children, early pubic hair and growth acceleration suggest premature adrenarche. Markedly high results raise concern for congenital adrenal hyperplasia or an adrenal tumor.

Big picture, DHEA-S connects the HPA axis to metabolic, skeletal, skin, and reproductive health. Persistently abnormal values warrant context with related hormones, because extremes can signal adrenal pathology, while intermediate shifts relate to long-term risks such as metabolic and reproductive complications in hyperandrogenic states.

What insights will I get?

A DHEA Sulfate (DHEA‑S) blood test measures the sulfated storage form of dehydroepiandrosterone made chiefly in the adrenal cortex. It tracks adrenal androgen output and the precursor pool for local sex‑steroid synthesis. This links to energy, metabolism, bone, brain, and immune balance.

Low values usually reflect reduced adrenal production or suppressed ACTH signaling. Common contexts are normal aging, chronic illness, hypopituitarism, and glucocorticoid exposure. System‑wide, this means less substrate for androgen/estrogen formation, trending toward lower anabolic tone, libido, mood, and stress resilience—especially noticeable in postmenopausal women.

Being in range suggests steady zona reticularis function and an age‑ and sex‑appropriate precursor supply for balanced steroidogenesis. Healthy individuals most often sit near the midrange for their demographic; no universal consensus supports low‑ or high‑normal as “best.”

High values usually reflect adrenal overproduction of androgens. Typical causes include congenital adrenal hyperplasia, adrenal‑dominant polycystic ovary syndrome, ACTH excess, or adrenal tumors; in children, premature adrenarche. Effects stem from androgen excess—acne, oily skin, hirsutism or menstrual disruption in females, and virilization when very high.

Notes: Interpret with age‑ and sex‑specific reference intervals; DHEA‑S peaks in early adulthood and declines thereafter, with minimal daily variation. Pregnancy, estrogen therapy, oral contraceptives, and glucocorticoids lower levels; renal impairment can raise them. Assay method and exogenous DHEA use materially affect results.