Key takeaway:
Superpower ($199/year) and OneTwenty ($499/year) are both membership biomarker services. Superpower gives a 100+ health-metric baseline in one draw, with a protocol, on-demand care, gut testing, and a supplement and prescription marketplace, available now. OneTwenty runs quarterly bloodwork fused with daily wearable data and prescription access, currently in beta.
Other companies you should compare
Superpower vs OneTwenty, compared
Superpower and OneTwenty are both membership-based biomarker testing services. Superpower is $199 a year and includes 100+ health metrics in one draw, plus a personalized protocol, on-demand care-team access, and a supplement and prescription marketplace.
OneTwenty is $499 a year and runs quarterly bloodwork (~85 biomarkers) fused with daily wearable data, with prescription access when clinically indicated. It opened applications for its closed beta in November 2025, ahead of a public launch.
What biomarker testing means
A biomarker testing company offers blood-based testing on a membership basis. Biomarkers are measurable signals in your blood: things like cholesterol, blood sugar, and hormones.
Some platforms stop at data and a report. Others turn those numbers into a plan you can follow. Two questions separate them: how much do they measure, and what do they help you do next?
Superpower and OneTwenty answer both differently. One ships a full ecosystem today; the other tracks trends continuously, in beta.
The Superpower process
Superpower keeps it simple:
- Join for $199 a year.
- Give one blood draw, at a lab or at home for an added fee.
- Get 100+ health metrics in your dashboard.
- Receive a personalized action plan.
- Message your care team on demand.
Testing reaches 2,000+ partner locations across 40+ states. You can shop a supplement marketplace with member-exclusive pricing, and prescription and peptide access is available in the marketplace (medications priced separately).
A biological-age score is built into every Superpower membership, with an optional OrganAge add-on for a deeper organ-level view. Gut microbiome testing is available as an add-on. Results arrive in 5 to 10 business days.
The OneTwenty process
OneTwenty runs on continuous tracking. You give quarterly blood draws, four a year, drawn at home or at a nearby lab, and sync daily data from wearables like Oura and Apple Health, with continuous glucose monitor integration coming soon.
OneTwenty pairs your labs with an AI that reads every signal, reviewing your protocol each quarter. Licensed clinicians step in when labs indicate clinical need, and prescriptions (TRT, GLP-1, HRT) are titrated to your data when appropriate.
There's no live supplement marketplace yet, and the product is still in its founding-member beta. Its real edge is catching trends between annual snapshots.
Markers measured, head to head
This is the comparison point buyers scrutinize most, so precision matters. The two count on different bases.
- Headline count — Superpower: 100+ health metrics*; OneTwenty: ~85 biomarkers (markets "165 lab signals/yr")**
- Counted from — Superpower: One blood draw; OneTwenty: Baseline + quarterly retests
- Derived ratios — Superpower: Included; OneTwenty: Direct lab tests
*Superpower's 100+ combines direct lab measurements with calculated ratios like LMR, MLR, and Ferritin:Albumin.
**OneTwenty's "165 lab signals" counts its ~85 baseline biomarkers plus smaller quarterly retests of a focused set of markers over a year, not 165 distinct biomarkers. Counted like with like, Superpower's single draw measures more distinct metrics than OneTwenty's ~85 baseline.
Acting on your numbers
Both services act on results, but the loops differ. Superpower includes on-demand access to a care team you can message, plus prescription and peptide access (GLP-1, TRT, peptides) and a curated supplement marketplace with member-exclusive pricing.
OneTwenty also offers prescriptions - TRT, GLP-1, and HRT - when clinically indicated, paired with its AI insights and quarterly clinician review.
Where they split: OneTwenty's supplement marketplace isn't live yet, and it doesn't offer gut microbiome testing. Superpower keeps testing, supplements, Rx, and care under one membership, available today.
Cost, side by side
Superpower costs $199 a year. OneTwenty costs $499 a year at its founding rate (a higher $749 rate applies in New York and New Jersey). Superpower's membership is HSA/FSA eligible, so pre-tax dollars can cover it.
The value math depends on what you want. Superpower bundles 100+ health metrics, a custom protocol, 20+ add-on panels, and a marketplace of supplements and prescriptions into one annual membership. OneTwenty's higher fee buys quarterly cadence and wearable integration.
They retest differently, though. OneTwenty includes four draws a year, but each quarterly retest covers only a focused set of markers, not the full baseline. Superpower re-runs the complete 100+ metrics every time and lets you retest on your own schedule, a full follow-up for $179 whenever you want one, instead of a fixed quarterly cadence. The real trade is coverage and flexibility, not price: OneTwenty gives frequent, narrower check-ins on a set schedule, while Superpower gives the full picture each test and the freedom to choose when to repeat it. One is a complete baseline you can buy now; the other is continuous tracking, still in beta.
Best fit for you
Superpower is best for:
- People who want to spend less.
- People who want a protocol and care, not just data.
- People who prefer one blood draw a year.
- People who want supplement, gut, and prescription access in one place.
- People who want to start today.
OneTwenty is best for:
- Data-driven optimizers who want quarterly trend tracking.
- People who want tight wearable integration.
- People comfortable with beta access while it scales.
In summary
OneTwenty and Superpower both aim to track your biology over time. OneTwenty's continuous quarterly-plus-wearable tracking is a genuine draw for trend-watchers, and it offers prescriptions too.
But Superpower gives you 100+ health metrics in one draw, plus a protocol, care, gut testing, and a supplement and prescription marketplace, at less than half the entry price, available today, not in beta.
Quarterly trend lines are worth having, but only once you have a baseline worth tracking. Superpower gives you that now, and 60% of its members say it flagged something a doctor had previously missed or overlooked. Get the full picture first; the trends can follow.
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