Which costs less, OneTwenty or Rythm?

OneTwenty costs less over a year at its $499 founding-member price, against $948 for twelve Rythm kits at $79. The OneTwenty figure ends at public launch, and its supplement packs and medications cost extra. Rythm adds shipping and tax to each kit.

Is OneTwenty open to everyone?

OneTwenty is accepting founding members and says founding pricing ends at public launch. Its membership runs in 49 states, all but Rhode Island, and renews each year at the then-current rate.

How does Rythm collect a sample compared with OneTwenty?

Rythm uses the Tasso+ device for a self-collected capillary sample, and FedEx picks it up from your home. OneTwenty draws blood from a vein at a lab, or at your door for $99.

Do OneTwenty or Rythm offer prescriptions?

OneTwenty does, through independent licensed providers, with medications and hormone therapy from $49 a month on top of the membership. Rythm states that it does not prescribe, and suggests following up with your primary care provider.

How fast do OneTwenty and Rythm results arrive?

Rythm quotes results within 2 days of the sample reaching its lab, and its kit takes about 2 to 3 business days to arrive. OneTwenty's results typically take about a week.

Are OneTwenty and Rythm HSA/FSA eligible?

Yes. Rythm lists itself as HSA/FSA eligible, and OneTwenty says most members can use HSA or FSA funds, depending on their plan.

OneTwenty vs Rythm: Features & Pricing (2026)

Key takeaway:

OneTwenty ($499/yr founding-member price) pairs a wide baseline panel with three targeted retests, a health coach, and daily device sync. Rythm ($79/mo) mails a small at-home kit every month and returns results within 2 days of the lab receiving it. If you want more than recurring panels and a dashboard, Superpower ($199/yr) goes beyond biomarker testing to be a true home for health. It sets one 100+ biomarker draw beside add-on tests and scans, a supplement marketplace, and Superpower AI to turn results into a protocol, with compounded prescriptions (like peptides) available when clinically appropriate, priced separately.

What is OneTwenty, and what is Rythm?

OneTwenty sells a membership it calls a physical that never ends. Bloodwork runs every quarter, wearables sync every day, and a protocol updates as the numbers move. The company is still accepting founding members, and its founding-member pricing ends at public launch.

Rythm is built around one claim: the easiest blood test. A kit arrives each month and you collect a sample at home. Results follow within about two days of the lab receiving it.

Both want testing to become routine. They differ on how much gets measured each time, and on who collects the sample.

What does OneTwenty include?

OneTwenty's membership covers a baseline panel, three targeted retests, a health coach, an AI assistant, and a personalized action plan. Medications and custom supplement packs are billed on top.

The company describes five steps:

Sign up — Join as a founding member.
Schedule labs — Walk into a lab, or have a phlebotomist come to you, and an independent licensed provider orders the panel.
Connect devices and past labs — Link a wearable, scale, or blood pressure monitor, and import earlier results.
Results plus action plan — Your coach walks through the labs, and the protocol covers training, sleep, nutrition, and supplements.
Retest quarterly — Focused panels every 90 days target the markers that need watching.

Every lab marker and device reading rolls up into a single One Health Score, scored from 0 to 100. OneTwenty calls itself a membership, not a medical practice, so prescriptions come from independent licensed providers.

What does Rythm include?

A Rythm subscription delivers one at-home kit every 30 days, with a dashboard, a Rythm Score, biological age, and the Rythm AI Coach. A physician signs off on every result before release.

Rythm shows three steps on its homepage:

At-Home Test — Use the Tasso+ device to collect a capillary sample.
Send (Mail or get picked up) — Return the sample by scheduled FedEx pick-up or drop-off.
Results within 2 days — Read your report in the Rythm app.

The sample is tested at Rythm's own CLIA-certified, CAP-accredited laboratory. Rythm says it does not prescribe, and it offers no additional tests today. An add-on option is on its roadmap.

What biomarkers do OneTwenty and Rythm measure in 2026?

OneTwenty lists 101 markers at baseline and follows with three targeted panels. Rythm's monthly panel is 25+ biomarkers, with separate versions for men and women. Both counts include calculated values, but only OneTwenty's list carries urinalysis (21 urine results).

	OneTwenty	Rythm
Initial draw	94-97 biomarkers (86-89 distinct and 8 calculated)	27-28 biomarkers (21-22 distinct and 6 calculated)
Follow-up draw	Three targeted panels of 20 to 40 markers, included	A new kit every month, skippable for up to 90 days
Headline count	161 to 221 lab results a year	25+ biomarkers per kit

Rythm tests a smaller set many times. OneTwenty measures a wider set at the start and narrows from there. A bigger number in one column says little without the other column's cadence.

OneTwenty's add-ons are:

Custom Packs — A daily supplement pack cut from your latest panel, from $67 a month.
Medications — Medications and hormone therapy through independent providers, from $49 a month, with the markers a prescription affects added to your next quarterly panel.
Devices — Extra monitoring tools at discounted member pricing.

Rythm sells one subscription and nothing beside it, with no add-on tests or scans yet.

What are the official 2026 membership prices for OneTwenty and Rythm?

OneTwenty costs $499 a year at founding-member pricing, or $749 in New York and New Jersey. Rythm costs $79 a test, delivered monthly.

OneTwenty bills annually and renews at the then-current rate, so the $499 figure will not last past public launch. A walk-in draw is included, and a phlebotomist at your door costs $99.

Twelve Rythm kits at $79 come to $948, plus shipping and tax. Members can skip up to 90 days without being charged for those months. A first purchase carries a 90-day money-back guarantee, with conditions.

Add-ons change OneTwenty's total, since supplement packs start at $67 monthly and medications at $49 monthly, each billed separately. Both memberships are eligible for HSA and FSA payment, though OneTwenty marks its own as reimbursement eligible with a caveat: your plan has the final say.

Venous draw or capillary kit: how each one collects your blood

OneTwenty draws blood from a vein, either at a walk-in lab at no extra cost or from a phlebotomist at your door for $99. In New York and New Jersey, the membership price rises because state collection rules limit its lab network.

Rythm hands the collection to you. The Tasso+ device draws a capillary specimen into standard tubes, and FedEx collects the sample from your home at no charge.

The choice affects effort more than anything else. OneTwenty asks for an appointment a few times a year, while Rythm asks for a few minutes every month.

How often does each one test?

OneTwenty follows an annual cycle: a full baseline at the start, then targeted retests that follow the markers needing attention. Which markers repeat depends on your baseline.

Rythm recommends testing every month and allows a skip of up to 90 days for a quarterly rhythm. It suggests at least three tests to set a baseline.

Results speed follows the same split. Rythm quotes results within 2 days of the sample reaching its lab, helped by testing a much smaller set of biomarkers. OneTwenty reports about a week.

Get 100+ biomarkers tested, in-lab or at home

One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.

Book your test

Get 100+ biomarkers tested, in-lab or at home

One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.

Book your test

Who answers your questions after the results?

OneTwenty pairs each member with a dedicated health coach. Its AI assistant monitors incoming data and points you to your own doctor when something needs medical attention.

Rythm's support is the AI Coach, included with every active subscription. A state-licensed physician reviews results as a release step, which is a lab safeguard and not a consultation. Members can share a PDF, CSV, or link with their own doctor.

Prescriptions split them too: Rythm does not prescribe, while OneTwenty routes medications through independent licensed providers. Medication is its last step, after lifestyle changes and supplements, and only when your data and a provider back it.

Where are OneTwenty and Rythm tests available?

OneTwenty is available in 49 states, all but Rhode Island.

Rythm says it serves all 50 states. A member needs a U.S. address that FedEx can reach, and Rythm does not ship internationally.

Who is OneTwenty best for, and who is Rythm best for?

OneTwenty is best for:

People who want a wide baseline and targeted retests through the year
People who want a coach and daily device sync in one dashboard
People who want supplement packs and medications billed in the same account

Rythm is best for:

People who want frequent, low-effort testing with no appointments
People who want results within 2 days of the lab receiving the sample
People in Rhode Island, where OneTwenty is not available

The bottom line

OneTwenty and Rythm both make testing routine, at opposite paces. OneTwenty measures broadly once, retests in targeted panels, and surrounds the numbers with a coach and device data. Rythm sends a smaller panel every month and returns it fast.

Neither sells add-on tests or scans. OneTwenty's extras are supplement packs and medications, billed monthly on top of its $499 founding-member price.

Superpower adds that layer to one $199 membership in most states. That is below both OneTwenty's $499 founding-member price and Rythm's $948 across twelve kits. It includes one draw of 100+ biomarkers, plus add-on tests and scans, supplements at up to 20% off, and prescriptions available when clinically appropriate, priced separately. Superpower AI turns your results, wearable data, and records into a Superpower Protocol. Superpower says 93% of members found their action plan more useful, even life-changing, than a yearly checkup.

Blood work is where a health plan starts, not where it ends. Build your home for health with Superpower today.