Which costs less, Empirical Health or OneTwenty?

Empirical Health costs less, at $190 once against OneTwenty's $499 a year. OneTwenty's figure is founding-member pricing that ends at public launch, and it covers four draws a year.

Does OneTwenty test more than Empirical Health?

Across a year, yes: OneTwenty reports 161 to 221 lab results, built from a baseline of 101 markers plus three targeted panels. On a single draw, Empirical lists 85 lab biomarkers and OneTwenty lists 94-97.

Do Empirical Health or OneTwenty offer prescriptions?

Both do. At Empirical Health, prescriptions come up in the doctor video visit that the $399 Advanced program includes. OneTwenty sells medications and hormone therapy, from $49 a month, with independent licensed providers writing the orders.

Does Empirical Health or OneTwenty sell supplements?

OneTwenty sells Custom Packs, a personal daily supplement pack from $67 a month on top of the membership. Empirical Health does not offer a supplement marketplace.

Is OneTwenty open to everyone?

Yes, as a founding member: the site reads "Now accepting founding members" ahead of public launch. It serves 49 states, all except Rhode Island.

Are Empirical Health and OneTwenty HSA/FSA eligible?

Yes, with conditions at OneTwenty. Empirical Health is HSA/FSA eligible. OneTwenty says most members can use HSA or FSA funds, though final eligibility depends on the plan.

Empirical Health vs OneTwenty: Features & Pricing (2026)

Key takeaway:

Empirical Health ($190 one-time) sells a single heart-focused panel of 100+ biomarkers, with a physician-interpreted report attached. OneTwenty ($499/yr founding price) is a membership that reruns bloodwork every quarter and syncs your devices daily. If you want an add-on catalog of scans and specialty tests beside a broad panel, Superpower ($199/yr) goes beyond biomarker testing to be a true home for health. It pairs one draw of 100+ biomarkers with that marketplace, and Superpower AI turns your results, wearables, and records into a protocol.

What is Empirical Health, and what is OneTwenty?

Empirical Health is a heart-focused service. You pay $190 once for a panel, and a physician-interpreted report and heart risk scores follow.

OneTwenty pitches its membership as a physical that never stops: quarterly bloodwork, daily device syncing, and a protocol that updates as your numbers move. It is selling memberships at founding-member pricing ahead of its public launch.

The two diverge on what surrounds the panel, with OneTwenty adding supplements and medications to the membership and Empirical keeping to the lab and the doctor.

What does Empirical Health include?

The one-time $190 payment buys 100+ biomarkers in a single lab visit, in-app heart risk scores, and Empirical Pro access for tracking history.

Empirical's homepage splits the experience into three steps:

Measure — Check 100+ biomarkers at any of 2,200 testing sites, ApoB and Lp(a) among them.
Predict — Model how your lifetime heart risk moves with lifestyle choices.
Prevent — Get a custom nutrition plan, photo meal logging, and an exercise routine.

Most results arrive in 3-5 business days. The $399 Advanced program layers on two retests, at 3 and 9 months, plus a video appointment with a board-certified doctor.

What does OneTwenty include?

OneTwenty's membership is built on a baseline panel and four checkpoints a year. Its how-it-works page calls the process "Five steps. One system.":

Schedule labs — Baseline bloodwork is drawn at home or at a lab, ordered by an independent licensed provider.
Wearables — Connect the device you already own.
Connect your scale and blood pressure monitor — Body composition and heart data flow in automatically.
Get your action plan — Labs and device data become a protocol covering training, sleep, nutrition, and supplements.
Track in real time and get adjusted — The dashboard updates daily, and the protocol follows.

Members can import past results from other labs, and an AI assistant reads the data and answers questions from it.

What biomarkers do Empirical Health and OneTwenty measure in 2026?

OneTwenty counts more lab results across a year, and Empirical counts more on a single draw than any one OneTwenty follow-up. Both lists include urinalysis and calculated values.

	Empirical Health	OneTwenty
Initial draw	85 lab biomarkers (72 distinct and 13 calculated)	94-97 biomarkers (86-89 distinct and 8 calculated)
Follow-up draws	Repeat testing at 3 and 9 months, Advanced program only	Three targeted panels of 20 to 40 markers, included
Headline count	100+ biomarkers on one draw	161 to 221 lab results a year

OneTwenty labels each year in four stages, from a year-start baseline to next year's plan, on its what-we-test page. Retests cover the markers that need watching, and which ones depends on your baseline. Final markers differ for New York and New Jersey members.

Add-ons look different at each company:

Empirical Health — The Advanced program, with repeat testing and the doctor visit.
OneTwenty — Custom supplement packs, medications, and discounted devices, all billed on top of the membership. There is no add-on test catalog: a prescription adds the markers its prescriber monitors to your quarterly panel.

What are the official 2026 membership prices for Empirical Health and OneTwenty?

Empirical Health charges $190 once, or $399 for its Advanced program. OneTwenty's $499 annual membership is a founding-member price, and the site states that it ends once the company launches publicly.

Both have a New York and New Jersey price. Empirical adds a $99 lab fee for $289 in total, and OneTwenty's founding pricing card lists $749 a year.

OneTwenty's walk-in draw is included, and an at-home draw is $99. Its add-ons bill monthly or quarterly, with Custom Packs from $67 and medications from $49. Members can cancel within 7 calendar days of purchase if no services have started, less a 3% processing fee.

Neither company bills insurance for testing. Empirical is HSA/FSA eligible, and OneTwenty labels its membership HSA/FSA reimbursement eligible, and says final eligibility rests on each member's plan.

Supplements and medications: what each sells around the panel

OneTwenty sells a personal supplement pack, cut from your latest panel, from $67 a month. It holds 63 ingredients across eight categories and is reformulated every quarter. That is the company's own pack, not a store stocked with other brands.

Empirical Health does not offer a supplement marketplace. Its report points to nutrition and exercise, and the supplement aisle stays outside the product.

Both bring in licensed providers for prescriptions. Empirical's come from the video visit in its $399 program. OneTwenty's medications and hormone therapy start at $49 a month and are issued by independent licensed providers. Coaching and supplements come first in its sequence, "and only then medication if your data and a provider support it."

Testing cadence: one snapshot or four

OneTwenty runs four draws a year, with a walk-in draw included or a phlebotomist at your door for $99. Empirical's $190 panel is one lab visit, and repeat testing at 3 and 9 months comes with the $399 program.

Empirical recommends testing at least once a year, or every 3 to 6 months while you are changing habits or managing risk with a doctor.

OneTwenty says results take about a week, and Empirical says most results arrive within 3-5 business days.

Coaching, devices, and scores

Empirical Health puts a physician-interpreted report at the center and lets members message doctors in the app. A wearable is optional, and supported ones include Apple Watch, Pixel Watch, Galaxy Watch, and Fitbit.

OneTwenty pairs a dedicated health coach with an AI assistant, while independent licensed providers handle anything clinical. Oura and Withings plug in directly, while any other device reaches OneTwenty through Apple Health or Google Fit.

OneTwenty's membership score is a 0 to 100 One Health Score, which it bases on the American Heart Association's Life's Essential 8. Biological age is a free standalone calculator on its site, separate from the score. Empirical does not offer a biological age score.

Get 100+ biomarkers tested, in-lab or at home

One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.

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Get 100+ biomarkers tested, in-lab or at home

One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.

Book your test

Where are Empirical Health and OneTwenty tests available?

OneTwenty is available in 49 states, everywhere except Rhode Island, through a national lab network. Empirical Health's draw sites number 2,200+, and its doctor visits cover people in over 30 states.

Who is Empirical Health best for, and who is OneTwenty best for?

Empirical Health is best for:

People who want ApoB and Lp(a) in a heart-focused panel at a one-time price.
People who want a doctor-interpreted report without a recurring membership.
People who prefer to handle supplements on their own.

OneTwenty is best for:

People who like quarterly checkpoints with a health coach behind them.
People who want Oura or Withings data beside lab trends.
People who want custom supplement packs and medications on the same dashboard.

The bottom line

Empirical Health is the shorter commitment, a heart panel and a doctor-read report. OneTwenty is the fuller loop, with quarterly draws, daily device data, and add-ons.

Both models are organized around the panel itself. Empirical's $190 covers a single draw, while OneTwenty's $499 founding price covers four panels, with its supplements and medications billed on top.

Superpower's price is $199 a year in most states for a 100+ biomarker draw, below OneTwenty's $499 founding-member price, and Empirical's panel runs $190 once. OneTwenty retests every quarter, and Superpower does not. Inside the marketplace you will find supplements at up to 20% off, add-on tests and scans, and prescriptions available when clinically appropriate, priced separately. Your results, wearable data, and medical records feed one Superpower AI, which writes your Superpower Protocol and coaches you as new data comes in. Superpower says 93% of members found their action plan more useful, even life-changing, than a yearly checkup.

Blood work is where a health plan starts, not where it ends. Build your home for health with Superpower today.