Which tests more biomarkers, Empirical Health or Hone Health?

Empirical Health publishes the larger list, at 100+ high-signal biomarkers including ApoB and Lp(a), against Hone Health's 50+ biomarkers. The lists are weighted differently, so which markers appear matters more than the totals: Hone Health's is hormone-led rather than whole-body, and Empirical Health's is spread across systems.

Does Empirical Health or Hone Health include a doctor?

Both do, in different forms. Empirical Health is a licensed medical practice with in-house physicians, positioned as primary care and covering lab orders, imaging, and specialist referrals. Hone Health includes a clinician-led care plan on Premium, with consults available for a fee on Basic.

Can I use an HSA or FSA for Empirical Health or Hone Health?

Hone Health lists its membership as eligible, subject to plan type, and provides receipts for submission. Empirical Health's FAQ confirms its membership is HSA/FSA eligible too. Superpower's $349-a-year membership is HSA/FSA eligible.

Empirical Health vs Hone Health: Features & Pricing (2026)

Key takeaway:

Empirical Health and Hone Health price two different products. Empirical Health charges $190 once for a comprehensive panel read by physicians inside its own licensed medical practice. Hone Health charges $65 for the initial test then $155 a month on Premium, roughly $1,925 a year before medication, because the subscription funds an ongoing treatment program rather than testing alone. However, if you want a flat annual price and support that continues between tests, Superpower is $349 a year and pairs 150+ health metrics with a built-in retest, on-demand care-team messaging, and a personalized action plan; 60% of members said Superpower identified something previously missed or overlooked by a doctor.

How do Empirical Health and Hone Health compare?

Empirical Health sells a one-time $190 panel, while Hone Health sells an ongoing subscription that runs roughly $1,925 a year before medication on Premium. The difference between these two shows up on the invoice before it shows up anywhere else. Empirical Health sells a panel: $190 for the comprehensive panel, one time, read by physicians inside its own licensed medical practice. Hone Health sells a program: $65 for the initial test then $155 a month on Premium, which comes to roughly $1,925 before medication across a year.

That gap is not a discount on the same thing. Empirical Health is priced like a primary care purchase, with 100+ high-signal biomarkers behind the single fee. Hone Health is a treatment subscription built on repeat testing rather than a testing subscription on its own, and its 50+ biomarkers lean toward hormones because the destination is therapy. So the useful question is not which one is cheaper. It is whether you are buying a picture of your health or an ongoing course of treatment.

What are the official 2026 membership prices for Empirical Health and Hone Health?

Empirical Health's price is a purchase, and Hone Health's is a standing commitment.

Empirical Health: lists $190 one-time for the comprehensive panel; also offers a $399-a-year Advanced Heart Health program bundling custom repeat testing at 3 and 9 months.
Hone Health: Premium is $65 initial test then $155 a month plus medication, which annualizes to roughly $1,925 before a single prescription is filled; Basic is $25 plus $25 onboarding, then $25 monthly, with consults available for a fee. The monthly fee buys repeat testing on a published schedule: Hone Health retests its 50+ key biomarkers every 3 months on Premium and every 6 months on Basic.

How many biomarkers does each membership test, Empirical Health's or Hone Health's, in 2026?

Empirical Health publishes 100+ high-signal biomarkers, with ApoB and Lp(a) among them, which are the particle measures a standard cholesterol panel leaves out. Hone Health publishes 50+ biomarkers, weighted toward hormones rather than spread across the whole body. The two counts are aimed at different things.

Breadth and depth answer different questions. If you do not yet know where to look, a wider panel is what surfaces the marker you were not thinking about, which is the case for Empirical Health's list. If you already suspect the question is hormonal, a hormone-weighted panel gives you more resolution in that one area, and Hone Health's is assembled to feed a treatment decision rather than a general survey.

Who reads your results at Empirical Health versus Hone Health?

Both put a clinician in the loop, at different depths. Empirical Health is a licensed medical practice with in-house physicians, positioned as proactive primary care, so clinical evaluation, lab orders, imaging, and specialist referrals sit inside one relationship. Hone Health includes a clinician-led care plan on Premium, while on Basic consults are available for a fee.

Prescribing is where that split becomes concrete. At Empirical Health, prescribing is part of the practice, issued as clinical care rather than sold as its own product. At Hone Health, prescribing is the point of the membership, which is built around testosterone therapy, weight loss and sexual health prescriptions, with medication billed separately from the plan.

So the choice is about the relationship you want after the blood draw. One is a doctor's office that happens to start with a comprehensive panel and can take you anywhere a doctor's office goes. The other is a focused program that starts with hormones and is designed to end in a prescription, if the results support one.

How do Empirical Health and Hone Health compare on turnaround, HSA dollars, and supplements?

Hone Health publishes more of the operational detail, which is worth reading before you commit to a monthly fee.

	Empirical Health	Hone Health
Extra processing time	—	Estradiol testing for men adds 2 to 3 business days on top
Biological age / longevity score	No biological age score	No biological age score
Supplement storefront	No supplement marketplace on its published pages	Nine own-brand supplements from $25 to $80, free shipping included

Test 150+ biomarkers

Two blood draws a year. Get a full picture of your health and the action plan you need to improve it.

Book your test

Test 150+ biomarkers

Two blood draws a year. Get a full picture of your health and the action plan you need to improve it.

Book your test

Who is Empirical Health best for, and who is Hone Health best for?

Empirical Health is best for:

Someone who wants one purchase rather than a subscription: $190, one time, for a whole-body panel.
Someone who wants the clinician reading the panel to also order the imaging, make the referral, and handle the prescription inside one primary care relationship.

Hone Health is best for:

Someone whose goal is treatment, with testosterone therapy or weight loss prescriptions inside a clinician-led plan.
Someone who wants a low entry point and published logistics: $25 monthly on Basic, HSA and FSA eligibility subject to plan type, and a stated turnaround.

The bottom line: does Empirical Health or Hone Health fit you?

Choose Empirical Health if you want a wide read and a doctor who can act on it. Choose Hone Health if the outcome you have in mind is a therapy you stay on. Empirical Health and Hone Health are priced for different jobs. Empirical Health is a $190 comprehensive panel inside a licensed medical practice, broad at 100+ high-signal biomarkers, with physicians who can order whatever comes next. Hone Health is a subscription that funds treatment: $155 a month on Premium plus medication, or $25 a month on Basic, with 50+ biomarkers weighted toward hormones underneath it.

Superpower: not one panel, and not one system

Each of these two stops at a predictable point: Empirical Health's $190 panel closes with the results, and Hone Health's Premium plan, roughly $1,925 a year before medication, points its 50+ hormone-weighted biomarkers at a treatment program rather than a general read. Superpower is built to be the general read. $349 a year covers 150+ health metrics across an initial complete draw of ~90 and a built-in follow-up later in the year that repeats ~60 key trackable markers, a count that combines direct lab measurements with calculated metrics across both draws — a whole-body read rather than a hormone-led one, and a membership rather than a panel bought once. Hormones sit inside that read rather than defining it, so a hormonal answer arrives with the rest of the body around it. Biological age tracking is included in every membership, and it is tracked closely enough to have helped 36.3% of Superpower members reduce their biological age score between their first and second year.

One panel answers what it was assembled to answer, and a hormone program answers hormones. Start your health journey with Superpower and start from a read that covers the rest of you too.

Frequently asked questions

Empirical Health has the lower published figure at $190 one-time for the comprehensive panel, and it also offers a $399-a-year Advanced Heart Health program. Hone Health charges $65 for the initial test then $155 a month on Premium plus medication, roughly $1,925 across a year, or $25 plus $25 onboarding, then $25 monthly on Basic. The two are not buying the same thing: Hone Health's fee funds an ongoing treatment program rather than testing alone.

Hone Health's help center puts an in-lab draw at 10 days of processing, plus 1 to 2 business days of physician review, and estradiol testing for men adds 2 to 3 business days. Its at-home hormone lab panel runs on its own clock, about 4 business days after the lab receives your sample, plus the same 1 to 2 business days of review. Collection is a separate choice: a Quest visit, an at-home visit from a mobile phlebotomist arranged through GetLabs, free of charge for initial labs on the Optimization and Women's Optimization programs and charged for follow-up labs, with availability varying by location, or, on the men's hormone panel route, an at-home hormone kit you collect yourself and ship back in the provided packaging within 24 hours. Empirical Health's FAQ puts its own results back in 3-5 business days.

It depends on what you want the blood test to lead to. Empirical Health gives you a wider read for a single fee, 100+ high-signal biomarkers inside a primary care relationship that can order the next step. Hone Health gives you a narrower, hormone-led panel attached to testosterone therapy and weight loss prescriptions, billed monthly with medication separate. One is breadth plus a doctor; the other is a treatment program you subscribe to.