Hone Health vs OneTwenty

What is Hone Health, and what is OneTwenty?

Hone Health calls itself an online clinic. Bloodwork leads into a physician-built care plan, with medication and supplements shipped to your door.

OneTwenty sells a yearly membership built on repetition: a baseline blood panel, quarterly retests, and daily data from your devices. It is still taking founding members ahead of its public launch, so every OneTwenty price below carries that qualifier.

The two part ways on what the fee buys. Hone's fee pays for a physician's time and a prescription program. OneTwenty's pays for a year of measurements.

What does Hone Health include?

Hone's Premium plan costs $155 a month after a $65 initial test, and Basic costs $25 a month, with medication billed on top of either one.

Hone's four-step Premium path reads:

1. Measure what matters — A comprehensive biomarker test opens the program.
2. Consult with a licensed physician — A private video visit covers your results, symptoms, history, and goals.
3. Ongoing personalized care — Repeat testing and clinician support continue alongside medications and supplements.
4. Optimize your health — You retest and see your clinician again every 3 months.

Basic drops the included consult. Results arrive on a dashboard, retests come every 6 months, and a physician visit costs $75 for men or $100 for women. Plus, a third tier, is a men's hormone program with its own 8 to 11 biomarker kit. Hone publishes no biological-age or longevity score.

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What does OneTwenty include?

OneTwenty's founding membership covers four blood draws a year, daily device syncing, a dedicated health coach, and an AI health assistant. Its five-step process runs:

1. Sign up — One annual membership, billed up front.
2. Schedule labs — A walk-in draw costs nothing extra, and a phlebotomist at your door costs $99.
3. Connect devices and past labs — Wearables, a scale, a blood pressure monitor, and earlier results land in one dashboard.
4. Results plus action plan — Labs, device readings, and body data combine into a personal protocol.
5. Retest quarterly — Focused panels every 90 days recheck the markers that need watching.

The protocol climbs in three tiers: lifestyle coaching, then custom supplement packs, then prescriptions through independent licensed providers. OneTwenty's biological age sits in a free calculator on its website, apart from the membership's One Health Score, scored from 0 to 100.

What biomarkers do Hone Health and OneTwenty measure in 2026?

Hone Health lists 50+ biomarkers on Basic and Premium. OneTwenty publishes 101 markers at baseline plus a custom panel of 20 to 40 markers each quarter, or 161 to 221 lab results a year.

The bases differ in one way. OneTwenty's list includes 21 urine results, while Hone's published list carries no urinalysis. OneTwenty's later panels also cover only the markers your baseline flags.

Hone's imaging add-ons:

• Whole-body MRI — Prenuvo scans, offered at a discounted Hone rate.
• Body composition — BodySpec DEXA scans, open to all members.

OneTwenty frames its year as a four-part cycle: a full baseline, a targeted retest, a progress check, and a plan for the next year. It sells no add-on tests or scans; extra markers join the quarterly panel only alongside a prescribed medication.

What are the official 2026 membership prices for Hone Health and OneTwenty?

Hone Health bills $1,860 a year for Premium and $300 for Basic, before medication. OneTwenty charges $499 a year as founding-member pricing that, in its own words, ends at public launch.

Hone's first year runs a little higher once opening tests are counted: $1,925 on Premium, which starts with a $65 test, and $350 on Basic, which adds a $25 test and a $25 onboarding fee.

OneTwenty's founding-member price is $749 in New York and New Jersey, which covers the at-home draws required there. Elsewhere, its at-home draw adds $99, and Custom Packs and medications bill monthly on top of the membership, like Hone's medication. Hone does not accept insurance. Hone calls its services HSA/FSA eligible, OneTwenty calls its membership HSA/FSA reimbursement eligible, and your plan has the final say.

Which supplements does each membership offer?

Hone Health runs a storefront, and OneTwenty builds a pack.

Hone's nine own-brand supplements run from $25 to $80, ship free, and carry physician backing. Basic members also get member-only pricing on supplements and medication.

OneTwenty's Custom Packs turn your latest results into one daily pack, from $67 a month. The formulary draws on 63 ingredients across eight categories and is reformulated every quarter as your numbers move.

A storefront suits someone who already knows what to take. A pack suits someone who wants the labs to decide, and will pay a monthly fee to have that done.

Who guides your care once the results arrive?

On Hone Premium, a physician consult is part of the membership. You meet your clinician every 3 months and message the care team without limit. Basic members can book a visit for a fee. Prescriptions anchor the program, spanning hormone, thyroid, weight, heart, and sexual health, plus longevity, and medication is priced separately. Men moving onto hormone therapy are billed for a confirmatory lab as well: $25 on Premium, and on Plus $45 at a lab or $80 by home kit.

OneTwenty describes itself as "a health optimization membership, not a medical practice." A dedicated coach walks you through results, an AI assistant answers questions between draws, and independent licensed providers order the panel and handle anything clinical. OneTwenty works through lifestyle, then supplements, "and only then medication if your data and a provider support it." Medication is an add-on from $49 a month, filled by independent licensed pharmacies.

How quickly do results arrive?

Hone publishes its timing. At-lab panels take about 10 business days to process, followed by 1 to 2 business days of physician review. At-home panels run about 4 business days from when the lab receives the sample, with the same review on top.

OneTwenty's turnaround is typically about a week, according to a Crown Counseling comparison page updated September 26, 2026.

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One membership, one blood draw. Get a full picture of your health and the action plan you need to improve it.

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Where are Hone Health and OneTwenty tests available?

Hone Health draws at 2,000+ partner labs. GetLabs home visits are free for initial labs on its Optimization programs, then member-paid. At-home hormone kits are for men, as women test at a lab. Its availability table shows no plan in 13 states and Washington, D.C., New Jersey among them.

OneTwenty serves 49 states, all but Rhode Island. New York and New Jersey members pay more, $749 in founding-member pricing, because state collection laws keep it off its usual lab network, and its final markers there differ from the national panel.

Who is Hone Health best for, and who is OneTwenty best for?

Hone Health is best for:

• People who want a physician to own the plan and prescribe medication.
• People who want a supplement storefront and a $300-a-year Basic entry point.
• People who prefer monthly billing to one annual payment.

OneTwenty is best for:

• People who want four draws a year and daily device data in one dashboard.
• People who want supplements built from their own labs.
• People comfortable with founding-member pricing ahead of a public launch.

The bottom line

Hone Health fits best when medication is the goal, because a physician and a prescription program anchor the membership. OneTwenty fits if a year of tracking is the goal, with four draws, device data, and a coach.

Both memberships bill the things you act on as separate purchases. Hone's medication bills on top of $155 a month, and OneTwenty's Custom Packs and medications bill on top of its $499 founding price.

Superpower's flat $199 a year in most states sits below Hone Basic's $300, OneTwenty's $499 founding price, and Hone Premium's $1,860, though OneTwenty's fee covers four draws to Superpower's one. That draw reads 100+ biomarkers, and Superpower AI combines it with wearable data and medical records to write your Superpower Protocol, backed by AI and care team support. Add-on tests and scans share the marketplace with member-priced supplements, up to 20% off. Prescriptions are available when clinically appropriate, priced separately. 93% of members found their action plan more useful, even life-changing, than a yearly checkup.

Blood work is where a health plan starts, not where it ends. Build your home for health with Superpower today.