Roseburia hominis: A Sentinel for Fiber Fermentation and Barrier Support

REVIEWED BY

William Maish, MD MBA MPH

Clinical Product Lead

Published

Last updated

Key takeaway:

Measures levels of Roseburia hominis, a beneficial butyrate-producing gut microbe that supports intestinal barrier function and helps limit inflammation. Detecting low levels can highlight microbiome imbalances linked with inflammatory bowel disease, irritable bowel syndrome and metabolic inflammation, enabling targeted interventions that may lower risk.

Read more →

Understand what your gut health results really mean

See your biomarkers in context with a comprehensive panel.

  • CLIA-certified labs
  • HIPAA compliant
  • Personalized health protocol
Book your test

Roseburia hominis: A sentinel for fiber fermentation and barrier support

A Roseburia hominis test analyzes DNA or RNA from a small stool sample to identify and quantify R. hominis living in your digestive tract. Results reflect a current snapshot of your gut ecosystem rather than a permanent trait.

Why focus on R. hominis? This bacterium ferments fibers to produce butyrate, a short‑chain fatty acid that fuels colon cells, supports tight junctions in the gut barrier, and helps keep immune signaling in check. Balanced levels are often seen in diverse, fiber‑adapted microbiomes. While microbiome science is evolving, consistent themes have emerged: higher diversity and a stable pool of butyrate producers are hallmarks of gut resilience, with R. hominis serving as a useful sentinel for fiber fermentation capacity and barrier integrity.

Join 150,000+ others building better health

Get the science behind better health, every week.

By clicking “Subscribe” you agree to our Terms of Service and Privacy Policy.

Why measure this specific butyrate producer

Connecting the dots from biology to daily life, measuring Roseburia hominis can help identify a pattern called dysbiosis when levels are consistently low relative to reference groups. Observational research links reduced R. hominis with conditions characterized by gut barrier stress and inflammation, including inflammatory bowel disease and features of metabolic syndrome, though associations do not prove causation. Testing can also clarify how recent antibiotics, low‑fiber eating patterns, hectic travel, or restrictive diets may have shifted your butyrate‑producing community, which in turn affects stool consistency, gas, and post‑meal comfort.

Zooming out, your microbiome interacts with digestion, immunity, and metabolism through metabolites like butyrate and the gut–brain axis. Watching your R. hominis level over time helps you see how real‑world changes — from fiber variety to recovery after illness or a new medication that alters GI motility — influence microbial stability. The goal is not to chase a single “perfect” number but to understand your pattern and trajectory so you and your clinician can make informed, preventive decisions grounded in your biology.

Reading a Roseburia hominis result

Results are typically presented as a proportion or percentile of Roseburia hominis compared with a reference population, sometimes alongside genus‑level context or functional pathway readouts. In general, “balanced” microbiomes tend to show meaningful representation of butyrate producers (including R. hominis, Faecalibacterium, and others) and overall higher diversity, whereas very low R. hominis or marked skewing toward inflammation‑associated species may signal an imbalanced ecosystem. Exact thresholds vary by lab due to different sequencing methods and databases, so interpretation focuses on relative patterns, not a single universal cutoff.

If your R. hominis is within an expected range for your lab’s reference group, that often aligns with efficient short‑chain fatty acid production, a calmer inflammatory tone, and a sturdier gut barrier. In practical terms, people in this category may notice more predictable stools and less reactivity to routine dietary changes. “Optimal” still looks different across individuals because diet, geography, and age shape the microbiome’s baseline.

If your R. hominis is low, your report is flagging a potential gap in fiber fermentation capacity and butyrate supply — not a diagnosis. Lower levels can reflect recent antibiotics or GI infections, limited intake of fermentable fibers, or broader diversity loss. In research, reduced R. hominis has been observed in inflammatory gut conditions and some metabolic settings, though more study is needed to define causality and clinical thresholds. Conversely, unusually high readings may indicate a temporary bloom or a shift in relative abundance due to decreases in other taxa, rather than true overproduction.

Test 150+ biomarkers

Two blood draws. A full picture of your health, explained in plain language.

Book your test

What bumps a Roseburia hominis number up or down

Context matters. Stool testing captures lumen microbes, not those tightly associated with the gut lining; day‑to‑day variability, stool water content, and colonoscopy prep can shift results. Different methods (16S vs metagenomics vs targeted qPCR) vary in species‑level precision, and most reports provide relative abundance rather than absolute counts. Life stage also influences interpretation: infants and young children are still establishing butyrate producers; older adults may see gradual declines; pregnancy involves natural microbiome shifts that should be interpreted with prenatal care in mind. Your roseburia hominis test becomes most actionable when paired with other data — for example, combining R. hominis with stool calprotectin, fecal short‑chain fatty acids, and metabolic markers can sharpen whether findings reflect transient change or a pattern worth clinical follow‑up. Over time, repeated measurements help you and your clinician evaluate how changes in diet quality, stress load, sleep, and activity relate to microbial stability and your digestive comfort.

Frequently Asked Questions

References

  1. Tamanai-Shacoori Z, Smida I, Bousarghin L, Loreal O, Meuric V, Fong SB, Bonnaure-Mallet M, Jolivet-Gougeon A (2017). Roseburia spp.: A marker of health? *Future Microbiology*, *12*, 157-170. https://doi.org/10.2217/fmb-2016-0130
  2. Rivière A, Selak M, Lantin D, Leroy F, De Vuyst L (2016). Bifidobacteria and butyrate-producing colon bacteria: Importance and strategies for their stimulation in the human gut. *Frontiers in Microbiology*, *7*, 979. https://doi.org/10.3389/fmicb.2016.00979
  3. Morrison DJ, Preston T (2016). Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. *Gut Microbes*, *7*(3), 189-200. https://doi.org/10.1080/19490976.2015.1134082
  4. Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasbarrini A, Mele MC (2019). What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. *Microorganisms*, *7*(1), 14. https://doi.org/10.3390/microorganisms7010014
  5. Allaband C, McDonald D, Vázquez-Baeza Y, Minich JJ, Tripathi A, Brenner DA, Loomba R, Smarr L, Sandborn WJ, Schnabl B, Dorrestein P, Zarrinpar A, Knight R (2019). Microbiome 101: Studying, analyzing, and interpreting gut microbiome data for clinicians. *Clinical Gastroenterology and Hepatology*, *17*(2), 218-230. https://doi.org/10.1016/j.cgh.2018.09.017

Led by doctors with 40 years of health and longevity expertise

Dr. Anant Vinjamoori

Dr. Anant Vinjamoori, MD

Chief Longevity Officer, Superpower

Dr. Leigh Erin Connealy

Dr. Leigh Erin Connealy, MD

Clinician & Founder of The Centre for New Medicine

Dr. Robert Lufkin

Dr. Robert Lufkin, MD

Physician & UCLA Medical School Professor, NYT bestselling author

Dr. Abe Malkin

Dr. Abe Malkin, MD

Founder & Medical Director of Concierge MD

Biological age 32 — a Superpower member portraitA health system built around you — test, understand, optimize150+ biomarkers across 2 blood drawsWhat to expect with Superpower — week 1 to month 3Trusted by 64,000+ customers — member reviewsBetter than the status quo — Superpower vs the old way60% of members found something a doctor missed — member survey
Daniel OSuperpower memberDavid LSuperpower memberRachel DSuperpower memberCamelia VSuperpower member

4.6 · 64,000+ members

Superpower health membership

Find early signs of 1,000+ conditions - then act, retest, and see what changed.

$349

/year*

150+ biomarkers annually across baseline + retest

Personalized plan that turns results into action

Superpower AI and on-demand care team

Results in 10 days or less

At-home or 2,000+ labs nationwide**

Yearly membership$0.96 / dayHSA/FSA eligible

*Pricing may vary for members in New York and New Jersey

**At-home labs for an additional cost

What we test

TestosteroneFree T4Vitamin DApoBHbA1cThyroid (TSH)hs-CRPFerritinCortisolFasting insulin

60%

found something a doctor missed

93%

rated it more useful than their checkup

77%

found something new in their results

Superpower member survey, 90 days post action plan (n=143).

How does the Superpower membership work?

We test 150+ biomarkers annually across two blood draws. Your baseline test paints a comprehensive picture of your health, and your dashboard shows what’s working, what needs attention, and what to do next. Superpower AI and your care team help you take action across lifestyle, supplements, and treatments. Then we retest to track your progress and continue refining your plan.

Can I cancel anytime?

Yes. You can cancel anytime, no fees. Your membership stays active through the end of your paid year.

How often should I test?

Your membership includes two blood tests per year: one to establish your baseline, and one to see whether your plan improved biomarkers that were out of range or not yet optimized. You can add other diagnostics anytime through the app or with help from your care team.

When will I get my results?

Book your draw at any of 2,000+ partner labs or at-home. Results are typically ready in about a week and land in the Superpower app.

What the 100+ panel measures

All 101 markers in your annual baseline draw, organized by system. Nothing here is an upsell.

Heart & Vascular Health

26

  • Apolipoprotein B
  • Atherogenic Coefficient
  • Atherogenic Index of Plasma
  • Castelli Risk Index I
  • Castelli Risk Index II
  • HDL Cholesterol
  • LDL Cholesterol
  • LDL/HDL Ratio
  • Cholesterol, Total
  • Non-HDL Cholesterol
  • Cholesterol/HDL Ratio
  • Carbon Dioxide, Total
  • High-sensitivity CRP
  • hsCRP-to-Albumin Ratio (CAR)
  • GGT-to-HDL Cholesterol Ratio
  • LDL-C to Apolipoprotein B Ratio (LDL-C/ApoB)
  • LDL Cholesterol / Total Cholesterol (Mass Ratio)
  • Monocyte-to-HDL Ratio (MHR)
  • Neutrophil-to-HDL Cholesterol Ratio (NHR)
  • Non-HDL Cholesterol-to-Apolipoprotein B Ratio (Non-HDL-C/ApoB)
  • NON-HDL Total Cholesterol Ratio
  • Triglyceride HDL Molar Ratio
  • Triglycerides
  • Triglyceride-to-Apolipoprotein B Ratio (TG/ApoB)
  • TyG Index
  • Uric Acid

Metabolic Health

4

  • Estim. Avg Glu (eAG)
  • Eag (mmol/l)
  • Glucose
  • Hemoglobin A1c

Energy

1

  • Cortisol

Liver Health

15

  • Albumin/Globulin Ratio
  • Albumin
  • Alkaline Phosphatase (ALP)
  • Alanine Aminotransferase (ALT)
  • Aspartate Aminotransferase (AST)
  • Bilirubin Direct
  • Bilirubin Indirect
  • Bilirubin, Total
  • Bilirubin-to-Albumin Ratio
  • Ferritin
  • Ferritin-to-Albumin Ratio
  • y-Glutamyl Transferase (GGT)
  • Globulin, Total
  • Indirect-to-Direct Bilirubin Ratio
  • Protein, Total

Kidney

11

  • Calcium
  • Chloride
  • Corrected Calcium (Albumin-adjusted)
  • Creatinine
  • Estimated Glomerular Filtration Rate (eGFR)
  • Potassium
  • Sodium
  • BUN/Creatinine Ratio
  • Blood Urea Nitrogen (BUN)
  • Urea-to-Creatinine Ratio
  • Uric Acid-to-HDL Cholesterol Ratio (UHR)

Sex Hormones

7

  • DHEA-Sulfate (DHEA-S)
  • Free Androgen Index
  • Sex Hormone Binding Globulin (SHBG)
  • Free Testosterone
  • Testosterone, Bioavailable
  • Testosterone, Total
  • Testosterone-to-Estradiol Ratio (T/E₂)

Thyroid Health

4

  • Free Thyroxine Index
  • T3 Uptake
  • T4 (thyroxine) Total
  • Thyroid-Stimulating Hormone (TSH)

Nutrients

13

  • Vitamin D
  • Red Cell Dist Width (RDW)
  • Hematocrit
  • Hemoglobin
  • Total Iron Binding Capacity (TIBC)
  • Iron
  • Iron Saturation
  • Mean Cell Hemoglobin (MCH)
  • Mean Corpuscular Hemoglobin Concentration (MCHC)
  • Mean Cell Volume (MCV)
  • Platelet-to-WBC Ratio (PWR)
  • Red Blood Cells
  • RDW MCV Ratio

Immune System

12

  • Basophils
  • Baso (Absolute)
  • Eosinophils
  • Eos (Absolute)
  • Lymphocytes
  • Lymphs (Absolute)
  • Monocytes
  • Monocytes (Absolute)
  • Neutrophils
  • Neutrophils (Absolute)
  • Mean Platelet Volume
  • Platelet Count

Inflammation

8

  • Lymphocyte-to-Monocyte Ratio (LMR)
  • Monocyte-to-Lymphocyte Ratio (MLR)
  • Neutrophil-to-Lymphocyte-Platelet Ratio (NLPR)
  • Neutrophil-to-Lymphocyte Ratio (NLR)
  • Platelet-to-Lymphocyte Ratio (PLR)
  • Systemic Immune-Inflammation Index
  • Systemic Inflammation Response Index (SIRI)
  • White Blood Cells
Get my health baseline

The full list of 100+ markers and 8 specialty add-ons available at superpower.com/biomarkers.