Which tests more biomarkers, Empirical Health or SiPhox Health?

Empirical Health lists 100+ high-signal biomarkers, including ApoB and Lp(a). SiPhox Health publishes a count per panel: 29 on Longevity Essentials and 59 on Ultimate 360, with Heart & Metabolic at 26, Thyroid Focus at 21, and Hormone Focus at 14. So Empirical Health runs the broader single panel, while SiPhox Health lets you pick the system you want depth in.

Is Empirical Health better than SiPhox Health?

It depends on what you want the results to lead to. Empirical Health is set up to act on them clinically, with physicians who can evaluate, refer, and prescribe after reading 100+ high-signal biomarkers. SiPhox Health is set up for frequent, low-friction measurement: collection at home, 7-10 days to results, coaching, and a biological age score, with no prescribing.

Are Empirical Health and SiPhox Health HSA/FSA eligible?

SiPhox Health lists its membership as HSA/FSA eligible, so pre-tax dollars can go toward it. Empirical Health's membership is also HSA/FSA eligible. Superpower's membership is HSA/FSA eligible.

Empirical Health vs SiPhox Health: Features & Pricing (2026)

Q: Do I have to visit a lab for Empirical Health or SiPhox Health?

Only for Empirical Health, which collects at one of 2,000+ testing sites. SiPhox Health collects at home with its EasyDraw upper-arm device, with no needles or finger pricks and no lab visit at any stage. If you want the option of either route, Superpower offers a lab draw or an at-home draw for an added fee.

Key takeaway:

Empirical Health and SiPhox Health part company at the blood draw. Empirical Health books you into one of 2,000+ testing sites and puts a licensed medical practice behind the panel, at $190 one-time for its comprehensive panel. SiPhox Health collects at home with an upper-arm device, no needles or finger pricks, at $125 per membership testing period, and does not prescribe. However, if you would rather have one price cover the testing and the follow-up questions both, Superpower is $349 a year, with a lab or at-home draw and care-team messaging that led 60% of members to say it identified something previously missed or overlooked by a doctor.

How do Empirical Health and SiPhox Health compare?

Two questions divide these companies: who reads the panel, and how often you buy one. Empirical Health sells a single comprehensive panel at $190 one-time, drawn at one of 2,000+ testing sites and read by in-house physicians working as primary care. SiPhox Health sells a repeating membership at $125 per membership testing period, collected by an EasyDraw upper-arm device with no needles or finger pricks, and returns insights, coaching, and an AI assistant rather than a physician's plan. Paying Empirical Health buys a clinical relationship that opens with a lab appointment. Paying SiPhox Health buys a measurement habit that never asks for one.

Where is the sample taken for Empirical Health and SiPhox Health, and what does each commit you to?

Empirical Health uses a conventional venous draw. You book a slot at one of 2,000+ testing sites, a phlebotomist takes the sample, and that visit doubles as the on-ramp to the practice that will read it. SiPhox Health removes that appointment from the sequence. An EasyDraw upper-arm device handles collection wherever you happen to be, with no needles or finger pricks, so a lab never sees you, only your sample.

For someone deciding, the question is less about comfort than about what each route is attached to. A site visit is a trip and an appointment, and it buys you a trained collector plus a practice standing behind the sample. At-home collection removes the appointment and the needle entirely, which is the difference between testing on a schedule you set and testing when the calendar allows.

It also shapes how often testing happens. Empirical Health's $190 comprehensive panel is a single test, so that site visit is a one-off unless you go back for another; its $399-a-year Advanced Heart Health program builds repeat testing at 3 and 9 months into the price instead. SiPhox Health builds the cadence into the membership, with the kit arriving monthly, quarterly, or every six months depending on the period you choose.

Does Empirical Health offer primary care, or does SiPhox Health offer coaching?

Empirical Health is a licensed medical practice with in-house physicians, positioned as primary care, with clinical evaluation, lab orders, imaging, and specialist referrals all in one place. Prescribing is part of that practice rather than a separate storefront: a prescription arrives as clinical care from the physician who read your panel. The second fork is wider than the first: what the company is licensed to do once your numbers are back.

SiPhox Health goes as far as guidance and stops there. It does not prescribe, and its GLP monitoring panel is a testing add-on for someone whose medication was already prescribed elsewhere, so it tracks a therapy rather than starting one. What it does provide is personalized insights, 1:1 health coaching, and an AI assistant, along with supplement and lifestyle recommendations. Its own pages describe it as a wellness-only service and point members to their own physician for a formal interpretation of the results.

Practically, the difference is how far a result can travel before it needs somebody else. If you expect the results to lead to a clinical evaluation, a referral, or a prescription, Empirical Health is built to carry them there, and a result that needs a prescriber inside SiPhox Health's model goes to your own doctor instead. If you already have a physician and want measurement, interpretation, and someone to talk the numbers through with, the clinical machinery is capacity you would be paying for and not using.

How many biomarkers does each membership test, Empirical Health's or SiPhox Health's, in 2026?

Empirical Health measures 100+ high-signal biomarkers, and names ApoB and Lp(a) among them, the particle-count markers that a standard cholesterol panel leaves out.

	Empirical Health	SiPhox Health
Biomarkers tested	100+	29 on Longevity Essentials, rising to 59 on Ultimate 360

Those two figures are counted differently, so read them as scope rather than a like-for-like tally. Empirical Health's 100+ is one comprehensive panel, and SiPhox Health's is a per-panel count that reaches up to 59 only if you buy the Ultimate 360 upgrade.

What are the official 2026 membership prices for Empirical Health and SiPhox Health?

Empirical Health's comprehensive panel is $190 one-time, and it also offers a $399-a-year Advanced Heart Health program bundling custom repeat testing at 3 and 9 months.

Empirical Health: $190 one-time is the full price of the panel; it also offers a $399-a-year Advanced Heart Health program bundling custom repeat testing at 3 and 9 months.
SiPhox Health: $125 per membership testing period, billed monthly, quarterly, or every six months depending on chosen cadence, so annual spend scales with how often you test. Two add-ons sit on top: the Ultimate 360 upgrade adds $125, and the GLP monitoring panel adds $75.

Test 150+ biomarkers

Two blood draws a year. Get a full picture of your health and the action plan you need to improve it.

Book your test

Test 150+ biomarkers

Two blood draws a year. Get a full picture of your health and the action plan you need to improve it.

Book your test

Who is Empirical Health best for, and who is SiPhox Health best for?

Empirical Health is best for:

Someone who wants a physician-led practice reading the panel, with clinical evaluation, imaging, referrals, and prescribing in one place.
Someone who wants one broad look at 100+ markers, including ApoB and Lp(a), for a single $190 payment.

SiPhox Health is best for:

Someone who would rather not sit for a needle, and wants the sample collected at home.
Someone who wants to retest on a chosen cadence and watch a BioAge score move between periods.

The bottom line: does Empirical Health or SiPhox Health fit you?

If you want the results acted on clinically, Empirical Health is set up for that; if you want frequent, low-friction measurement, SiPhox Health is. These two are selling different things. Empirical Health is a medical practice that starts with a $190 one-time panel of 100+ markers, taken at one of 2,000+ sites, and can end in a referral or a prescription. SiPhox Health is a needle-free at-home testing membership at $125 per testing period, with 29 markers on its base panel, coaching, and a biological age score, and no prescribing.

Superpower: one price, and no meter on the conversation

Both of these price a single shape of testing and stop there. Empirical Health's $190 covers one panel at one of 2,000+ testing sites, and a second look on that tier is a second purchase, though its $399-a-year Advanced Heart Health program builds repeat testing at 3 and 9 months into the price; SiPhox Health's $125 per testing period keeps the measurements coming, with 29 markers on the base panel and the Ultimate 360 upgrade at another $125, though a result that needs a prescriber leaves the platform. Superpower charges once for both halves. A flat $349 a year covers an initial draw returning ~90 health metrics and a built-in follow-up draw later in the year that repeats the same trackable markers — 150+ tests run across the two — alongside a personalized action plan and a 24/7 care team you message on any day. There is no upgrade tier deciding which markers you get, and no separate charge for asking about them.

A number you have to take somewhere else is a number that waits. Start your health journey with Superpower and keep the reading and the response in one membership.

Frequently asked questions

SiPhox Health has the lower single figure at $125 per membership testing period, though what you spend in a year depends on whether you test monthly, quarterly, or every six months. Empirical Health charges $190 one-time for its comprehensive panel, and also offers a $399-a-year Advanced Heart Health program. The two are not buying the same thing: Empirical Health's fee includes a medical practice reading the panel, and SiPhox Health's covers a testing period with insights and coaching.

Empirical Health does. It operates as a licensed medical practice with in-house physicians, positioned as primary care, and prescribing happens inside that practice. SiPhox Health provides personalized insights, 1:1 health coaching, and an AI assistant, and describes itself as a wellness-only service, pointing members to their own physician for a formal interpretation. Superpower includes on-demand care-team messaging plus a personalized action plan.