Autoimmune and Inflammation Screening

Some symptoms do not have an obvious cause: persistent joint pain, unexplained fatigue, recurring rashes, or morning stiffness that takes a while to loosen. When those symptoms linger, autoimmune activity and systemic inflammation are worth ruling in or out. The Autoimmune and Inflammation Screening panel pairs a foundational ANA screen with a joint-focused pair, rheumatoid factor and anti-CCP, and ESR as a marker of inflammation, from a single blood draw, with no doctor's visit required, and your results are delivered to your dashboard.

What this panel screens for

ANA, the antinuclear antibody, is a broad screening marker. It detects whether your immune system is producing antibodies against your own cell nuclei. A positive ANA can point toward systemic autoimmune activity. The reflex titer and pattern add context about how strong the signal is and what shape it takes.

Rheumatoid factor and anti-CCP, the cyclic citrullinated peptide antibody, are two joint-focused markers associated with rheumatoid arthritis. Rheumatoid factor is long established. Anti-CCP is more specific for rheumatoid arthritis and can appear early, sometimes before joint symptoms begin. Together they add a joint-focused layer alongside the ANA screen.

These conditions share symptoms with dozens of other problems: joint stiffness, fatigue, dry eyes, skin rashes, muscle aches. Because these conditions share symptoms with many others, antibody testing gives you and your provider an earlier, clearer starting point. This screen is the foundational first look.

Reference ranges vary by lab and individual. A result outside the reference range does not confirm a diagnosis. Your provider will interpret your results in the context of your symptoms, history, and any follow-up testing.

Signs this panel is worth considering

These are the patterns that often prompt providers to order autoimmune screening. The panel is relevant even when symptoms are vague or intermittent.

• You have unexplained joint pain, stiffness, or swelling, especially if it is worse in the morning
• You have persistent fatigue, dry eyes or mouth, skin rashes, or recurrent fevers
• You have a family history of lupus, rheumatoid arthritis, or other autoimmune conditions
• You have been given a vague label like "fibromyalgia" without autoimmune markers being checked
• You experience morning stiffness that takes more than 30 minutes to loosen
• You notice a recurring facial rash, or skin rashes with no clear cause
• You are monitoring symptoms of a known inflammatory condition over time
• You have had a positive ANA result in the past and want to track it

Understanding what your results mean

A result above the reference range is not a diagnosis. It is a signal worth exploring with a qualified provider.

What this panel reveals is whether your immune system is producing antibodies associated with systemic autoimmune activity. A positive result does not mean you have a diagnosis today, but it gives you and your doctor a clearer sense of what to monitor and when to investigate further. Identifying these patterns earlier can give you and your provider more context for what to monitor over time.

Antinuclear antibodies are present in a meaningful portion of the healthy population. Most people with a positive ANA do not have an autoimmune condition. The reflex titer and pattern add context to the signal, and a provider supplies the specificity that a screen alone cannot. If a more specific named-antibody profile is warranted, your provider can direct next-step testing.

What this panel gives you is a set of results that your provider can interpret alongside your symptoms, physical exam, and other labs. Some patterns warrant further investigation. Others are incidental findings with no clinical significance. The distinction requires context that only a provider can supply.

If your results show elevated markers, your Superpower care team can help you understand which values are flagged and what questions to bring to your provider.

Choosing the right autoimmune panel

If you are unsure which panel fits your situation, your Superpower care team can help you choose based on your symptoms and goals.

How it works

1. Order your panel. Select Autoimmune and Inflammation Screening when setting up your Superpower order. No doctor's visit or referral required.
2. Schedule your draw. Book at a local clinic, or opt for an at-home visit from a trained phlebotomist (+$119).
3. Complete your blood draw. A single blood draw covers every marker in the panel, processed in CLIA-certified labs. No urine sample needed.
4. Receive your results. Your results are typically ready within 10 days. Each flagged value is highlighted in plain language, with your Superpower care team available for questions.

What comes next

Your results arrive with each marker explained in plain language. If any values are flagged, your Superpower care team can help you understand what they mean and what questions to bring to your provider. For autoimmune patterns, the next step is always a clinical conversation with a provider, not a self-managed response.