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What should I know about semax dosage?
No standard Semax dosage is set in the US. See the fixed doses small human studies tested, from 0.25 mg once to 18 mg daily, and the forms Semax is sold in.
Quick answer
No standard Semax dosage exists in the US, because Semax is not a component of any FDA-approved drug and has no established labeled route. In Russia, Semax is a registered drug sold as 0.1% and 1% nasal drops. Small human studies tested fixed doses from a single 0.25 mg to 18 mg daily, in courses of up to 10 days. Every study that reports its route gave Semax intranasally. Most other Semax dose figures come from rats.
- Published
- November 4, 2026
- Last updated
- November 4, 2026
Why Semax has no standard US dosage
No US drug label sets a standard Semax dosage. As of 2026, Semax is not a component of any FDA-approved drug1. Semax's human dose data come from small Russian clinical trials, alongside rodent research. In Russia, Semax is a registered drug, available as 0.1% and 1% nasal drops1. A percent figure shows how concentrated a Semax solution is. That differs from the amount one dose delivers.
Optimal dosing regimens remain poorly defined for most peptides2 in published research. Without a label dose, the clearest Semax figures come from published human studies.
What Semax doses have human studies tested?
Small human studies tested fixed Semax doses, from a single 0.25 mg to 18 mg daily. Courses ran 2 to 10 days1. Those doses appear as fixed milligram amounts, or as amounts per kilogram of body weight. Some are drops of a 1% solution1.
Each Semax figure records what one research team gave, in that study's own units. None of them is a US dose.
Semax doses tested in people differ by study population, route, and unit.
| Study | Population | Route | Dose and unit | Duration |
| Healthy-volunteer study, 1996 | 19 healthy men | Intranasal | 1 mg (16 mcg/kg) daily1, or 0.25 mg once1 | 2 days, or a single dose |
| Brain-imaging study, 2018 | 14 healthy adults | Intranasal, 1% solution3 | 1.2 mg1 | Single administration3 |
| Pain study, 1996 | 37 adults with trigeminal neuralgia, dental plexalgia, or migraine | Intranasal | 0.5 mg/kg1 | Once |
| Peptic ulcer study, 2002 | 32 adults with peptic ulcer1, alongside standard therapy | Intranasal, 1% solution | 2-4 drops 3 times daily4 | 10 days4 |
| Acute stroke study, 1997 | 30 adults in the acute period of ischemic stroke | Not stated in the English abstract | 12 mg daily for moderate stroke5, or 18 mg daily for severe stroke5 | Courses of 5 or 10 days5 |
| Stroke rehabilitation study, 2018 | Adults after ischemic stroke, mean age 58 | Not stated in the abstract | 6,000 mcg daily6 | 2 courses of 10 days, 20 days apart6 |
| Motor neuron disease study, 2007 | 27 adults with motor neuron disease | Intranasal, 1% solution | 12 mg daily7 | 2 courses of 10 days, 2 weeks apart7 |
Most published Semax dose figures come from rats dosed by body weight.
What Semax doses have animal studies used?
Most Semax animal studies dose rats by weight, in micrograms per kilogram (µg/kg). FDA found no established link between Semax dose and effect1 across different routes.
Rat stroke-model studies gave Semax at 100 µg/kg by abdominal injection1 or 250 µg/kg intranasally1. One nasal course ran six days8.
In rats given 1.5 to 500 µg/kg1, the same doses acted differently by route9. Rat enzymes rapidly broke down intranasal Semax at 50 µg/kg10.
No rat dose converts into a human Semax dose. FDA found no human study of how the body handles Semax1 by any route.
What forms does Semax come in?
Semax is sold online as nasal sprays and freeze-dried powder for injection11. FDA found that human Semax research discusses only the intranasal route1. It found no literature on subcutaneous (under-the-skin) injection.
Nasal and injected Semax enter the body differently. Research or experience with one route does not automatically describe another.
What to check on a Semax product depends on its form.
| Form | What to check |
| Nasal spray or drops | Labeled concentration (percent or mg/mL); the exact compound (free base, acetate, or a derivative such as N-acetyl Semax, since FDA found derivatives sold under the same common name1); and whether the cited research used the nasal route |
| Injection | Concentration, vial strength, the exact compound, sterility, storage, who prepared the product, and the bacterial endotoxin and impurity data FDA found lacking1 |
Reconstituting freeze-dried Semax means mixing the vial's powder with a specified volume of bacteriostatic water. That is sterile water with a preservative. Vial strength and water volume turn a dose into a measured amount. The target Semax dose itself comes from the prescribing clinician.
Getting Semax in 2026
Superpower will offer Semax formulated in FDA-registered facilities in the US, backed by third-party lab testing, and distributed from US-licensed pharmacies. A licensed clinician will assess whether it fits each person's health care. Anyone interested can join the Superpower peptide waitlist now.
FDA has not approved Semax as a drug. Its compounded supply depends on an interim Department of Health and Human Services policy: in October 2026, the department said it does not intend to take enforcement action12 against state-licensed pharmacies compounding Semax and five other peptides13 while the 503A Bulks List, the roster of ingredients pharmacies may use in compounding, is finalized. Conditions include ingredients from FDA-registered facilities and a patient-specific prescription. The policy followed an FDA advisory committee's July 2026 recommendation to add Semax to the list14, and rulemaking remains underway.