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Brain & sleep
What should I know about epitalon dosage?
No standard epitalon dosage has been set for people. See the 5-10 mg daily range clinic websites report, the doses studies tested, and the forms sold.
Quick answer
No standard epitalon dosage has been established for people. Epitalon is not FDA-approved and has no established labeled route. Clinic websites describe 5 mg to 10 mg per day by subcutaneous injection or oral supplement. That is a reported practice pattern rather than a standardized dose. Three small, older human studies each tested a different dose and route. They used 0.01 mg per day intramuscularly, 0.5 mg per day sublingually, and 5 µg per eye per day by injection around the eye.
- Published
- November 4, 2026
- Last updated
- November 4, 2026
Why there is no standard epitalon dosage
No standard epitalon dosage has been set for people. Epitalon, also spelled epithalon, does not yet have adequate pharmacokinetic, dose-ranging, and long-term safety data1. Most published epitalon findings come from laboratory and animal research2. Human research includes three small studies1, each with its own dose and route.
Epitalon is not an FDA-approved drug in the United States1, so no label sets its dose, route, or schedule. FDA's 2026 evaluation found no absorption or clearance measurements, known as pharmacokinetic data3, for epitalon free base or epitalon acetate.
Commonly reported epitalon doses come from clinic websites.
What epitalon doses are commonly reported?
Reported epitalon protocols on clinic websites commonly cite 5 mg to 10 mg per day3. They describe subcutaneous injection (under the skin) or oral supplements. These are reported practice patterns rather than a standardized dose.
Epitalon cycles appear on some of those websites, and one describes use every four months3. Where a licensed clinician prescribes epitalon, that clinician sets the dose.
Published epitalon studies give a separate set of figures, the doses researchers tested in animals and people.
What doses have epitalon studies tested?
Epitalon studies tested fixed doses in animals and three small human groups. Each used its own route and schedule.
Epitalon is a synthetic four-amino-acid peptide (Ala-Glu-Asp-Gly) modeled on epithalamin, a bovine pineal gland extract2. An epithalamin dose is never an epitalon dose. One older study tested both preparations4 in elderly people and old monkeys.
| Study | Test article | Species or population | Route | Dose and unit | Duration |
| Mouse lifespan study, 2003 | Epitalon | Female SHR mice, 54 per group | Subcutaneous injection | 1 µg per mouse (about 30-40 µg/kg)5 | 5 consecutive days each month, from 3 months of age |
| Rhesus monkey study | Epitalon | Rhesus monkeys | Intramuscular injection (into a muscle) | 2 µg/kg per day3 | 10 days |
| Elderly adults study, 2007 | Epitalon | Elderly adults, 15 given epitalon | Intramuscular injection | 0.01 mg per day (0.1 mg per course)1 | 10 days |
| Night-shift study, 2020 | Epitalon (AEDG)6 | Women aged 40-50 with reduced melatonin production, mostly night-shift workers1 | Sublingual spray (under the tongue), twice daily | 0.5 mg per day3 | 20 days |
| Retinitis pigmentosa study, 2002 | Epitalon7 | 162 patients (324 eyes)1 with retinitis pigmentosa, an inherited retinal disease | Parabulbar injection (around the eye) | 5 µg per eye per day1 | 10 days |
The human doses are published schedules from older studies rather than a current regimen. Animal doses do not convert into a human dose chart. Epitalon products also differ in form and strength.
What forms does epitalon come in?
Epitalon is sold as injectable vials, capsules, and an oral spray3. Several seller websites label these products intended for research use only3.
Epitalon has primarily been studied in animals through subcutaneous injection2. Research on oral and intranasal epitalon2 so far comes from rats. Research or experience with one route does not automatically describe another.
The details worth checking on an epitalon product change with its form.
| Form | What to check |
| Injection (vial) | Vial strength (10, 20, 25, and 50 mg vials3 on sale); free base or salt form (commonly acetate or trifluoroacetate2); sterility, bacterial endotoxins, and particles3; storage; and who prepared the product |
| Capsule | The exact epitalon form, the strength (3 mg and 3.3 mg capsules3 on sale), and what supports its stability and absorption |
| Oral spray | Whether the research being cited used the same route and product |
Reconstituting an epitalon vial means mixing its freeze-dried powder with the specified amount of bacteriostatic water. Vial strength and water volume decide how a dose converts into syringe units. That dose is a prescribed target set by a licensed clinician.
Getting epitalon in 2026
Superpower will offer epitalon formulated in FDA-registered facilities in the US, backed by third-party lab testing, and distributed from US-licensed pharmacies. A licensed clinician will assess whether epitalon has a place in each person's health care. Anyone interested can join the Superpower peptide waitlist now.
Epitalon has no FDA approval as a drug. Under an interim policy announced in October 2026, the Department of Health and Human Services does not intend to take enforcement action8 against state-licensed pharmacies compounding epitalon and certain other peptides while the 503A Bulks List, which sets the ingredients pharmacies may use in compounding, is finalized. That policy covers epitalon and five other peptides9, under conditions such as ingredients from FDA-registered facilities and a patient-specific prescription. An FDA advisory committee had recommended adding epitalon to the list10 in July 2026, and rulemaking is still underway.