Understanding Your Arsenic Level: Exposure, Speciation, and Testing

REVIEWED BY

William Maish, MD MBA MPH

Clinical Product Lead

Published

Last updated

Key takeaway:

Quickly measure your personal arsenic level to detect elevated exposure so you can reduce contact and lower the risk of long-term arsenic-related problems such as certain cancers, heart disease, diabetes, and developmental harms in children.

Read more →

Understand what your heavy metals results really mean

See your biomarkers in context with a comprehensive panel.

  • CLIA-certified labs
  • HIPAA compliant
  • Personalized health protocol
Book your test

Arsenic and why speciation matters

The arsenic toxin test measures arsenic in the body, typically using urine, to quantify recent exposure and how you metabolize it. Most labs report total urine arsenic and, when needed, perform “speciation” to separate inorganic arsenic and its metabolites—monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA)—from organic seafood-related forms such as arsenobetaine. Results are expressed as concentrations (for example, micrograms per liter) or normalized to urine creatinine to account for hydration. Blood arsenic can reflect very recent or high-level exposure, while hair or nails may capture longer windows but are susceptible to contamination. Modern laboratories often use inductively coupled plasma mass spectrometry (ICP‑MS) for high sensitivity and specificity.

When arsenic becomes a health question

Why it matters: arsenic testing helps reveal how much exposure your body has had and how efficiently you’re converting and eliminating it through methylation pathways. These results touch multiple systems—detoxification, cellular repair, vascular integrity, metabolic control—and provide objective data that can uncover early risk before disease develops. By understanding your exposure and processing patterns, you gain insight into short-term function and long-term resilience.

Big picture: arsenic testing helps detect early warning signs and monitor progress as you address potential sources. It turns a foggy concept—“detox”—into actual data you and your clinician can interpret over time. The goal isn’t to “pass” or “fail,” but to understand where you stand and how your body adapts, guiding smarter prevention and long-term health.

Join 150,000+ others building better health

Get the science behind better health, every week.

By clicking “Subscribe” you agree to our Terms of Service and Privacy Policy.

Who should run an arsenic test

Arsenic is a naturally occurring element that can enter the body through water, food, or workplace exposure. Inorganic arsenic is the form most associated with health risk. Once inside, your body tries to neutralize and excrete it by adding methyl groups, creating MMA and DMA that leave through urine. Excess exposure or inefficient processing can stress cells and tissues, showing up as skin changes, pins-and-needles sensations, digestive upset, or shifts in blood pressure and glucose control. Testing is particularly relevant if you rely on private well water, eat rice or seaweed frequently, consume lots of shellfish, work in certain industrial settings, or use some traditional or herbal products that may contain metals. It’s also important when there are unexplained symptoms, or during pregnancy, when minimizing toxic exposures supports fetal development.

Reading an arsenic result

Your report typically shows arsenic levels as a number compared with a laboratory reference range, sometimes adjusted for urine creatinine. If speciation is performed, you’ll see the pattern: inorganic arsenic, MMA, and DMA separated from seafood-related arsenobetaine. “Normal” means typical for a reference population; “optimal” is a context-dependent concept—lower inorganic arsenic and a healthy methylation pattern are generally preferred. Context matters: a mildly elevated total can be benign after a seafood-heavy weekend, while a similar number dominated by inorganic forms deserves attention. Trends add power, especially when paired with symptoms and other labs.

Higher values can mean different things. A spike in arsenobetaine points toward seafood intake and usually does not indicate toxic burden. Elevation in inorganic arsenic and its methylated products (MMA and DMA) suggests true exposure your body is actively clearing. A higher percentage of MMA has been associated with greater risk in some research, though more studies are needed and individual interpretation is key. Very high blood arsenic may reflect a recent, significant exposure. Lower values typically indicate minimal recent exposure. Remember, concentrations in spot urine can shift with hydration, which is why creatinine correction or 24‑hour collections are sometimes used.

Test 150+ biomarkers

Two blood draws. A full picture of your health, explained in plain language.

Book your test

What can move an arsenic reading

Balanced results suggest low inorganic exposure and efficient methylation, often seen as a higher proportion of DMA relative to MMA, reflecting steady detoxification. Variation is expected, influenced by genetics (for example, AS3MT variants), diet, micronutrient status (folate and other one‑carbon cofactors), hydration, kidney function, and recent meals.

Limitations to know: timing matters because arsenic has a relatively short half‑life in blood and urine, so results reflect recent exposure more than long‑term accumulation. Hair and nail testing can be influenced by external contamination (for example, hair products or dust). Seafood can transiently elevate total urine arsenic due to arsenobetaine, which is considered less toxic. Not all laboratories perform speciation by default, and methods and reference ranges differ, which can affect comparison between labs. Abnormal numbers are not a diagnosis; they are clues that guide further evaluation with your clinician.

What an arsenic test can and can't tell you

The practical takeaway is pattern recognition. A clear decrease in inorganic arsenic species after a change in routine suggests you found a meaningful source. Stable, low levels indicate minimal current exposure and efficient clearance. When interpreted alongside your history, diet, water source, and related labs (like kidney and liver function), the arsenic toxin test turns scattered information into a coherent story you can use for prevention and longevity.

Frequently Asked Questions

References

  1. Hughes MF, Beck BD, Chen Y, Lewis AS, Thomas DJ (2011). Arsenic exposure and toxicology: A historical perspective. *Toxicological Sciences*, *123*(2), 305-332. https://doi.org/10.1093/toxsci/kfr184
  2. Hata A, Yamanaka K, Habib MA, Endo Y, Fujitani N, Endo G (2012). Arsenic speciation analysis of urine samples from individuals living in an arsenic-contaminated area in Bangladesh. *Environmental Health and Preventive Medicine*, *17*(3), 235-245. https://doi.org/10.1007/s12199-011-0247-5
  3. Agency for Toxic Substances and Disease Registry. (2007). *ToxGuide for arsenic*. U.S. Department of Health and Human Services. https://www.atsdr.cdc.gov/toxguides/toxguide-2.pdf
  4. Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ (2012). Heavy metal toxicity and the environment. *Experientia Supplementum*, *101*, 133-164. https://doi.org/10.1007/978-3-7643-8340-4_6
  5. Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL (2005). Urinary creatinine concentrations in the U.S. population: Implications for urinary biologic monitoring measurements. *Environmental Health Perspectives*, *113*(2), 192-200. https://doi.org/10.1289/ehp.7337
  6. Jones DR, Jarrett JM, Tevis DS, Franklin M, Mullinix NJ, Wallon KL, Quarles CD, Jr., Caldwell KL, Jones RL (2017). Analysis of whole human blood for Pb, Cd, Hg, Se, and Mn by ICP-DRC-MS for biomonitoring and acute exposures. *Talanta*, *162*, 114-122. https://doi.org/10.1016/j.talanta.2016.09.060

Led by doctors with 40 years of health and longevity expertise

Dr. Anant Vinjamoori

Dr. Anant Vinjamoori, MD

Chief Longevity Officer, Superpower

Dr. Leigh Erin Connealy

Dr. Leigh Erin Connealy, MD

Clinician & Founder of The Centre for New Medicine

Dr. Robert Lufkin

Dr. Robert Lufkin, MD

Physician & UCLA Medical School Professor, NYT bestselling author

Dr. Abe Malkin

Dr. Abe Malkin, MD

Founder & Medical Director of Concierge MD

Biological age 32 — a Superpower member portraitA health system built around you — test, understand, optimize150+ biomarkers across 2 blood drawsWhat to expect with Superpower — week 1 to month 3Trusted by 64,000+ customers — member reviewsBetter than the status quo — Superpower vs the old way60% of members found something a doctor missed — member survey
Daniel OSuperpower memberDavid LSuperpower memberRachel DSuperpower memberCamelia VSuperpower member

4.6 · 64,000+ members

Superpower health membership

Find early signs of 1,000+ conditions - then act, retest, and see what changed.

$349

/year*

150+ biomarkers annually across baseline + retest

Personalized plan that turns results into action

Superpower AI and on-demand care team

Results in 10 days or less

At-home or 2,000+ labs nationwide**

Yearly membership$0.96 / dayHSA/FSA eligible

*Pricing may vary for members in New York and New Jersey

**At-home labs for an additional cost

What we test

TestosteroneFree T4Vitamin DApoBHbA1cThyroid (TSH)hs-CRPFerritinCortisolFasting insulin

60%

found something a doctor missed

93%

rated it more useful than their checkup

77%

found something new in their results

Superpower member survey, 90 days post action plan (n=143).

How does the Superpower membership work?

We test 150+ biomarkers annually across two blood draws. Your baseline test paints a comprehensive picture of your health, and your dashboard shows what’s working, what needs attention, and what to do next. Superpower AI and your care team help you take action across lifestyle, supplements, and treatments. Then we retest to track your progress and continue refining your plan.

Can I cancel anytime?

Yes. You can cancel anytime, no fees. Your membership stays active through the end of your paid year.

How often should I test?

Your membership includes two blood tests per year: one to establish your baseline, and one to see whether your plan improved biomarkers that were out of range or not yet optimized. You can add other diagnostics anytime through the app or with help from your care team.

When will I get my results?

Book your draw at any of 2,000+ partner labs or at-home. Results are typically ready in about a week and land in the Superpower app.

What the 100+ panel measures

All 101 markers in your annual baseline draw, organized by system. Nothing here is an upsell.

Heart & Vascular Health

26

  • Apolipoprotein B
  • Atherogenic Coefficient
  • Atherogenic Index of Plasma
  • Castelli Risk Index I
  • Castelli Risk Index II
  • HDL Cholesterol
  • LDL Cholesterol
  • LDL/HDL Ratio
  • Cholesterol, Total
  • Non-HDL Cholesterol
  • Cholesterol/HDL Ratio
  • Carbon Dioxide, Total
  • High-sensitivity CRP
  • hsCRP-to-Albumin Ratio (CAR)
  • GGT-to-HDL Cholesterol Ratio
  • LDL-C to Apolipoprotein B Ratio (LDL-C/ApoB)
  • LDL Cholesterol / Total Cholesterol (Mass Ratio)
  • Monocyte-to-HDL Ratio (MHR)
  • Neutrophil-to-HDL Cholesterol Ratio (NHR)
  • Non-HDL Cholesterol-to-Apolipoprotein B Ratio (Non-HDL-C/ApoB)
  • NON-HDL Total Cholesterol Ratio
  • Triglyceride HDL Molar Ratio
  • Triglycerides
  • Triglyceride-to-Apolipoprotein B Ratio (TG/ApoB)
  • TyG Index
  • Uric Acid

Metabolic Health

4

  • Estim. Avg Glu (eAG)
  • Eag (mmol/l)
  • Glucose
  • Hemoglobin A1c

Energy

1

  • Cortisol

Liver Health

15

  • Albumin/Globulin Ratio
  • Albumin
  • Alkaline Phosphatase (ALP)
  • Alanine Aminotransferase (ALT)
  • Aspartate Aminotransferase (AST)
  • Bilirubin Direct
  • Bilirubin Indirect
  • Bilirubin, Total
  • Bilirubin-to-Albumin Ratio
  • Ferritin
  • Ferritin-to-Albumin Ratio
  • y-Glutamyl Transferase (GGT)
  • Globulin, Total
  • Indirect-to-Direct Bilirubin Ratio
  • Protein, Total

Kidney

11

  • Calcium
  • Chloride
  • Corrected Calcium (Albumin-adjusted)
  • Creatinine
  • Estimated Glomerular Filtration Rate (eGFR)
  • Potassium
  • Sodium
  • BUN/Creatinine Ratio
  • Blood Urea Nitrogen (BUN)
  • Urea-to-Creatinine Ratio
  • Uric Acid-to-HDL Cholesterol Ratio (UHR)

Sex Hormones

7

  • DHEA-Sulfate (DHEA-S)
  • Free Androgen Index
  • Sex Hormone Binding Globulin (SHBG)
  • Free Testosterone
  • Testosterone, Bioavailable
  • Testosterone, Total
  • Testosterone-to-Estradiol Ratio (T/E₂)

Thyroid Health

4

  • Free Thyroxine Index
  • T3 Uptake
  • T4 (thyroxine) Total
  • Thyroid-Stimulating Hormone (TSH)

Nutrients

13

  • Vitamin D
  • Red Cell Dist Width (RDW)
  • Hematocrit
  • Hemoglobin
  • Total Iron Binding Capacity (TIBC)
  • Iron
  • Iron Saturation
  • Mean Cell Hemoglobin (MCH)
  • Mean Corpuscular Hemoglobin Concentration (MCHC)
  • Mean Cell Volume (MCV)
  • Platelet-to-WBC Ratio (PWR)
  • Red Blood Cells
  • RDW MCV Ratio

Immune System

12

  • Basophils
  • Baso (Absolute)
  • Eosinophils
  • Eos (Absolute)
  • Lymphocytes
  • Lymphs (Absolute)
  • Monocytes
  • Monocytes (Absolute)
  • Neutrophils
  • Neutrophils (Absolute)
  • Mean Platelet Volume
  • Platelet Count

Inflammation

8

  • Lymphocyte-to-Monocyte Ratio (LMR)
  • Monocyte-to-Lymphocyte Ratio (MLR)
  • Neutrophil-to-Lymphocyte-Platelet Ratio (NLPR)
  • Neutrophil-to-Lymphocyte Ratio (NLR)
  • Platelet-to-Lymphocyte Ratio (PLR)
  • Systemic Immune-Inflammation Index
  • Systemic Inflammation Response Index (SIRI)
  • White Blood Cells
Get my health baseline

The full list of 100+ markers and 8 specialty add-ons available at superpower.com/what-we-test.