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MOTS-c (injection)

MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA. In animal studies, it activated AMPK, the cell's energy sensor, and increased glucose uptake into muscle. Your clinician reviews your labs and your monthly check-ins.

  • Studied in animal models of glucose handling and insulin resistance
  • Research explores its role in supporting energy and vitality
  • Prepared by a licensed US pharmacy
  • 40+ biomarker blood panel included
$199
/month
Limited-time early access pricing
Get first access
Medication is charged up front as a preorder
Target ship date is late November, pending pharmacy confirmation
If you're not approved for a prescription, you get a full refund
Selling fast, order now
First batch
Shipping late November
What is MOTS-c?

MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome, the cell’s own energy structures. MOTS-c is being studied for its role in metabolism, energy regulation and vitality, insulin sensitivity, exercise capacity, and healthy aging.

How is this different from buying peptides online?

Many peptides sold online are labelled “research use only”. MOTS-c is only prescribed after an assessment with a Superpower clinician, before it’s prepared by a licensed pharmacy.

How do I take it?

A small injection under the skin. If prescribed, you will be provided clear instructions for starting, and your clinician is there for any questions along the way.

Dr. Alex J. Tatem, MD
Answered by Dr. Alex J. Tatem, MD
Board-certified urologist & men’s health specialist
Clinician-assessed
Your health reviewed before prescription
Prepared by a licensed pharmacy
Compounding pharmacies in the USA
Blood panel included
40+ biomarkers, for deep understanding
Support beyond the first order
Follow-up, questions and treatment reviews
Meet MOTS-c

Vitality on a cellular level

Your Superpower clinician will review your health history and goals, and if appropriate, can prescribe MOTS-c to help you meet a more energetic you.

MOTS-c

A mitochondrial-derived peptide studied in metabolic signaling

What it is
A 16-amino-acid peptide your mitochondria make naturally, helping you maintain levels that tend to fall with age.
The research
Studied for its role in cellular energy and metabolism, mostly in cells and animals. Human studies are early.
Administered
Injection under the skin. Schedule set by your clinician.
Get first access
Charged up front as a preorder

Not sure if it’s right for you? Your clinician will explain the evidence, the risks and your alternatives as part of your assessment.

Clinician guided care

A clinician at every step, not just the first one.

Your Superpower clinician looks at your whole picture: your history, your goals, current medications and what you've already tried.
Prescribed only if it’s right for you
Every prescription is a clinical decision, made after a licensed clinician reviews your history, medicines and goals. If a peptide isn’t right for you, they’ll say so and tell you why.
Your plan comes with a plain-language read on what research shows, what users report and what’s still unproven. Questions go straight to your clinician.
Each month you complete a short check-in, and your clinician reviews it before your next refill ships. If you’re improving, you continue. If progress stalls or something new comes up, they adjust or stop. Your dose never changes without them.
Dr Alex Tatem, MD, board-certified urologist
Protocols prepared by Dr Alex Tatem, MD
Board-certified Urologist, Men’s health specialist, and member of Superpower’s Medical Advisory Board.
Clinicians are never incentivized to prescribe treatment
Explore your options

Is MOTS-c right for you?

  • You want to understand the research behind MOTS-c
  • You want a clinician to review your health history before starting
  • You prefer prescription care with clinician oversight
  • You are not taking a GLP-1 or diabetes medicine, since MOTS-c cannot be taken with them
  • You prefer a defined course with a planned pause and reassessment
Get first access

Eligibility is determined by a licensed clinician after reviewing your intake and labs.

Superpower clinician reviewing a care plan on a tablet
Getting started

Your old self, within reach

Step 01

Short online assessment

Share your goals in a short online assessment covering your energy, activity, health history and current medications. This gives your clinician the full picture and helps them assess whether MOTS-c is right for you.
Person completing the online assessment on a laptop
Select all that apply
Low energy
Weight gain
Strength loss
Step 02

A Superpower clinician makes the call

A licensed clinician reviews your responses thoroughly before prescribing. If MOTS-c isn’t right for you, they’ll explain why and talk you through your other options.
Superpower clinician reviewing results
Reviewing your results...
Step 03

If prescribed, receive your treatment

A licensed U.S. pharmacy prepares your prescription to the sterile compounding standards required for injectable medications. It arrives with your dose printed on the label, step-by-step injection instructions and the syringes and supplies you need.
MOTS-c compounded vial
Step 04

Ongoing check-ins and blood tests

Your purchase includes a 40+ biomarker baseline panel, so your clinician starts from your real numbers. Each month you complete a short check-in that your clinician reviews. Repeat labs follow every 6 months, or sooner if your clinician needs them. Questions in between go straight to your care team in the Superpower app.
Superpower app dashboard on a tablet
Get first access
Medication is charged up front as a preorder
Target ship date is late November, pending pharmacy confirmation
If you're not approved for a prescription, you get a full refund
More energy is a start

Superpower takes you further

Superpower
“Research use only”
MOTS-c
Safety and quality
4
Licensed clinician assessment before prescribing
Yes
None
Screening for medications and health history
Yes
None
Prepared in the US by a licensed pharmacy
Yes
Not required
Labelled for human use
Yes
No
Care and guidance
4
Guidance on evidence, risks and alternatives
Yes
None
Regular check-ins on how you're feeling
Yes
None
Clinician review before every refill
Yes
None
Unlimited clinician messaging
Yes
None
Your health picture
3
Blood panel covering metabolism, heart health, thyroid and more, in your first 60 days
Included
None
Routine blood testing every 6 months
Included
None
Results and health history, all in one app
Included
None
Superpower AI
4
Energy focused meal plans for an active week
Included
None
Sleep and activity insights from wearables
Included
None
Plain-English explanations of your results
Included
None
Support available 24/7
Included
None

Frequently asked questions

You’ll pay $199 when you pre-order. We’ll review your prescription request when we’re ready to ship. If approved, your next $199 payment will be charged 30 days after approval, then every 30 days after that.

Our commitment to quality comes before speed. We’re taking the time to ensure our peptides meet our standards before they ship. Preorder today to reserve your place in the first wave.

MOTS-c is a mitochondria-derived peptide being studied for its role in how cells use energy and regulate metabolism. Researchers are exploring its potential effects on glucose metabolism, exercise capacity and healthy aging. Its use as a treatment remains investigational.

Research is still early. We don’t yet have enough human evidence to know whether MOTS-c treatment improves energy, supports weight loss or extends lifespan. Your clinician can help you understand the research and what remains unknown. If you’re experiencing new or unexplained fatigue, they can also help assess potential causes.

No. MOTS-c is a different type of peptide and is not an established replacement for prescribed diabetes or weight-management treatment. Continue taking your prescribed medications unless your clinician recommends a change.

Under Superpower’s current protocol, MOTS-c is not offered to people who are taking, or have taken within the past three months, a GLP-1 medication, metformin or an SGLT2 inhibitor. Other glucose-lowering medications, including insulin and sulfonylureas, require individual clinical review. The three-month requirement is specific to our program; it does not establish a universally safe interval between treatments. Please don’t stop a prescribed medication to meet this requirement.

No. You can start MOTS-c without labs. You will be prompted to complete labs within the first 60 days of your cycle. There will be monitoring labs every 6 months. You may upload past labs prior to starting treatment if you would like your clinician to review them.

MOTS-c is a twice weekly injection, with doses kept 3-4 days apart. Your clinician will confirm your prescribed dose and schedule. Any changes to your dose should be agreed with them first.

The planned cycle is 12 weeks, followed by a 4-week break. Your clinician may stop treatment earlier if it isn’t helping or a safety concern comes up, and continuing after the break needs their reassessment and approval.

MOTS-c’s safety in humans has not been established, and its potential side effects and longer-term risks are not fully understood. Contact your care team promptly if you experience new fatigue, injection-site reactions, rash, dizziness, shakiness, sweating, weakness or confusion. Some of these symptoms can indicate low blood sugar and need clinical attention, particularly with glucose-lowering medications, fasting or exercise. Seek emergency care for severe confusion, fainting, seizures or difficulty breathing.

You’ll complete symptom check-ins every four weeks. During continued care, the protocol also includes CBC/CMP bloodwork every six months, along with any additional testing your clinician requires. These check-ins help guide decisions about ongoing treatment. New symptoms, medication changes or overdue monitoring may mean treatment needs to be paused or stopped.

$199 a month, inclusive of any labs, clinician messaging and use of Superpower AI.

Silhouette of a person by the sea at golden hour

Fuel for a full life

Afternoons without the slump. Evenings with energy to spare. Start your assessment to see if MOTS-c is right for you.

Get first access
MOTS-c
$199/month preorder
Get first access