MOTS-c (injection)
MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA. In animal studies, it activated AMPK, the cell's energy sensor, and increased glucose uptake into muscle. Your clinician reviews your labs and your monthly check-ins.
- Studied in animal models of glucose handling and insulin resistance
- Research explores its role in supporting energy and vitality
- Prepared by a licensed US pharmacy
- 40+ biomarker blood panel included
Compounded MOTS-c is not FDA-approved. A patient-specific prescription is required. Eligibility is determined by a licensed clinician after reviewing your intake and labs. MOTS-c is not available in all 50 states. Not HSA/FSA eligible.
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome, the cell’s own energy structures. MOTS-c is being studied for its role in metabolism, energy regulation and vitality, insulin sensitivity, exercise capacity, and healthy aging.
Many peptides sold online are labelled “research use only”. MOTS-c is only prescribed after an assessment with a Superpower clinician, before it’s prepared by a licensed pharmacy.
A small injection under the skin. If prescribed, you will be provided clear instructions for starting, and your clinician is there for any questions along the way.

Vitality on a cellular level
Your Superpower clinician will review your health history and goals, and if appropriate, can prescribe MOTS-c to help you meet a more energetic you.
MOTS-c
A mitochondrial-derived peptide studied in metabolic signaling
Not sure if it’s right for you? Your clinician will explain the evidence, the risks and your alternatives as part of your assessment.
A clinician at every step, not just the first one.

Is MOTS-c right for you?
- You want to understand the research behind MOTS-c
- You want a clinician to review your health history before starting
- You prefer prescription care with clinician oversight
- You are not taking a GLP-1 or diabetes medicine, since MOTS-c cannot be taken with them
- You prefer a defined course with a planned pause and reassessment
Eligibility is determined by a licensed clinician after reviewing your intake and labs.

Your old self, within reach
Short online assessment

A Superpower clinician makes the call

If prescribed, receive your treatment

Ongoing check-ins and blood tests

Superpower takes you further
MOTS-c
Frequently asked questions
You’ll pay $199 when you pre-order. We’ll review your prescription request when we’re ready to ship. If approved, your next $199 payment will be charged 30 days after approval, then every 30 days after that.
Our commitment to quality comes before speed. We’re taking the time to ensure our peptides meet our standards before they ship. Preorder today to reserve your place in the first wave.
MOTS-c is a mitochondria-derived peptide being studied for its role in how cells use energy and regulate metabolism. Researchers are exploring its potential effects on glucose metabolism, exercise capacity and healthy aging. Its use as a treatment remains investigational.
Research is still early. We don’t yet have enough human evidence to know whether MOTS-c treatment improves energy, supports weight loss or extends lifespan. Your clinician can help you understand the research and what remains unknown. If you’re experiencing new or unexplained fatigue, they can also help assess potential causes.
No. MOTS-c is a different type of peptide and is not an established replacement for prescribed diabetes or weight-management treatment. Continue taking your prescribed medications unless your clinician recommends a change.
Under Superpower’s current protocol, MOTS-c is not offered to people who are taking, or have taken within the past three months, a GLP-1 medication, metformin or an SGLT2 inhibitor. Other glucose-lowering medications, including insulin and sulfonylureas, require individual clinical review. The three-month requirement is specific to our program; it does not establish a universally safe interval between treatments. Please don’t stop a prescribed medication to meet this requirement.
No. You can start MOTS-c without labs. You will be prompted to complete labs within the first 60 days of your cycle. There will be monitoring labs every 6 months. You may upload past labs prior to starting treatment if you would like your clinician to review them.
MOTS-c is a twice weekly injection, with doses kept 3-4 days apart. Your clinician will confirm your prescribed dose and schedule. Any changes to your dose should be agreed with them first.
The planned cycle is 12 weeks, followed by a 4-week break. Your clinician may stop treatment earlier if it isn’t helping or a safety concern comes up, and continuing after the break needs their reassessment and approval.
MOTS-c’s safety in humans has not been established, and its potential side effects and longer-term risks are not fully understood. Contact your care team promptly if you experience new fatigue, injection-site reactions, rash, dizziness, shakiness, sweating, weakness or confusion. Some of these symptoms can indicate low blood sugar and need clinical attention, particularly with glucose-lowering medications, fasting or exercise. Seek emergency care for severe confusion, fainting, seizures or difficulty breathing.
You’ll complete symptom check-ins every four weeks. During continued care, the protocol also includes CBC/CMP bloodwork every six months, along with any additional testing your clinician requires. These check-ins help guide decisions about ongoing treatment. New symptoms, medication changes or overdue monitoring may mean treatment needs to be paused or stopped.
$199 a month, inclusive of any labs, clinician messaging and use of Superpower AI.

Fuel for a full life
Afternoons without the slump. Evenings with energy to spare. Start your assessment to see if MOTS-c is right for you.
Peptides offered through Superpower are compounded medications that have not been approved or authorized by the FDA. They are made available under an interim HHS enforcement discretion policy that may be revised or rescinded at any time, and they may not be available in all states. Evidence on their safety and effectiveness in humans is limited, and they are not appropriate for everyone. Treatment is available only if prescribed by a licensed clinician following an individual evaluation.
Read our informed medical consent



