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Biomarker testing is a laboratory analysis of genes, proteins, hormones, or other molecules in your blood or tissues to help assess your health, identify risk factors, or guide personalized care decisions. To learn more, read ourguides on biomarker testing.
What we test
Your biomarkers are more than just numbers. They give you a glimpse into how well your body is operating. Explore what’s measured in our biomarker blood tests so you can select the panels that are best for you.
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Brain health
0
Biomarker
Included in
Vitamin D
Baseline
Vitamin D is an essential and multifunctional micronutrient.
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Method: Usually performed by FDA-cleared immunoassay in CLIA-certified, CAP-accredited laboratories. If an LC/MS method is used at the performing site, the assay is a laboratory-developed test (LDT) validated under CLIA and not cleared or approved by the FDA. Results support clinician interpretation and are not a stand-alone diagnosis.
ABeta 42/40 Ratio
Baseline
The AB42/40 ratio is a calculated value derived from your plasma amyloid beta 42 and amyloid beta 40 levels.
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ABeta 40
Baseline
Amyloid beta 40 (AB40) is a small protein fragment produced when the brain processes amyloid precursor protein (APP).
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Abeta 42
Baseline
Amyloid beta 42 (AB42) is a 42-amino acid protein fragment produced when the brain processes amyloid precursor protein (APP).
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Apoe Genotype
Baseline
Apolipoprotein E (APOE) is a protein that plays a central role in how your body transports and metabolizes cholesterol and other fats — particularly in the brain.
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Vitamin B12
Baseline
Vitamin B12 powers energy, nerve function, and healthy red blood cells.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Cortisol
Baseline
Cortisol is a hormone made by the adrenal glands that helps you respond to stress and regulate various bodily functions.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
High-sensitivity CRP
Baseline
hs-CRP detects low-grade inflammation linked to heart disease and aging.
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Estradiol
Baseline
Estradiol is the main estrogen, shaping cycles, bone, mood, and heart health.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Folate (Folic Acid)
Baseline
Folate builds new cells and DNA, and works with B12 to drive methylation.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Free T3 (Triiodothyronine)
Baseline
Free T3 measures the unbound, biologically active portion of circulating T3.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Alzheimer's Genetic Risk (APOE)
Baseline
Reflects your APOE genotype, linked to cholesterol handling and susceptibility to late-onset Alzheimer's disease.
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Homocysteine
Baseline
Homocysteine is an amino acid that climbs when the methylation cycle stalls.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Insulin-like Growth Factor 1 (IGF-1)
Baseline
IGF-1 reflects growth hormone activity, driving repair, muscle, and recovery¹.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Insulin Fasting
Baseline
Fasting insulin reflects how much insulin the pancreas produces after an overnight fast.
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Insulin
Baseline
Insulin is the pancreatic hormone that moves sugar from blood into your cells.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
4-Hydroxybutyric
Baseline
4-Hydroxybutyric acid sits at a junction between amino-acid handling and nervous-system chemistry, normally present at low levels.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
5-Hydroxyindoleacetic (5-HIAA) (serotonin)
Baseline
5-HIAA is the main breakdown product of serotonin, the neurotransmitter associated with mood, sleep, and appetite, built from dietary tryptophan.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Dihydroxyphenylacetic (DOPAC) (dopamine)
Baseline
DOPAC is a dopamine breakdown product made by the enzyme MAO, depending on nutrients including B6, B2, magnesium, copper, and vitamin C.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Homovanillic (HVA) (dopamine)
Baseline
HVA is a breakdown product of dopamine, the neurotransmitter behind motivation, focus, drive, and reward, providing an indirect read on dopamine activity.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
HVA / DOPAC Ratio
Baseline
The HVA / DOPAC Ratio compares two dopamine breakdown products from related but distinct breakdown steps, reflecting the balance between two routes.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
HVA / VMA Ratio
Baseline
The HVA / VMA Ratio compares dopamine and adrenaline breakdown products to assess how readily dopamine is converted to norepinephrine via dopamine beta-hydroxylase.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Kynurenic
Baseline
Kynurenic acid travels the same tryptophan side road as a B6-dependent protective counterweight to inflammatory quinolinic acid, supporting and protecting nerve cells.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
N-Acetylaspartic
Baseline
N-Acetylaspartic acid comes from aspartate and is found in high concentrations in the nervous system, playing a role in brain metabolism.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Phenyllactic
Baseline
Phenyllactic acid forms from phenylalanine processing, an amino acid that is also the starting material for dopamine and other brain-signaling chemicals.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Quinolinic
Baseline
Quinolinic acid forms along a side road of tryptophan metabolism and is inflammatory in the brain, acting as an excitotoxin that ramps up with immune activation.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Vanillylmandelic (VMA) (norepinephrine, epinephrine)
Baseline
VMA is the main breakdown product of norepinephrine and adrenaline, reflecting how much of these stress chemicals the body is producing and clearing.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Phosphorylated tau217
Baseline
Phosphorylated tau 217 (pTau-217) is a modified form of tau — a structural protein that normally stabilizes the internal scaffolding of brain cells.
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Free Testosterone
Baseline
Free testosterone is the small unbound share your tissues can actually use.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Testosterone, Bioavailable
Baseline
Bioavailable testosterone is the free plus loosely bound share reaching tissues.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Testosterone, Total
Baseline
Total testosterone counts all of it in your blood, most bound and unavailable.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
DNA health
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Biomarker
Included in
Vitamin B12
Baseline
Vitamin B12 powers energy, nerve function, and healthy red blood cells.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Ferritin
Baseline
Ferritin is a blood protein that contains iron¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Folate (Folic Acid)
Baseline
Folate builds new cells and DNA, and works with B12 to drive methylation.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
RBC Folate
Baseline
RBC folate shows the folate stored inside your cells over recent months.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Homocysteine
Baseline
Homocysteine is an amino acid that climbs when the methylation cycle stalls.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Iron
Baseline
Iron is a mineral that is essential for many biological processes in the body, such as oxygen transport, muscle activity, mitochondrial function, DNA synthesis, and sensing of hypoxia⁵.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Methylmalonic Acid
Baseline
MMA builds up when your cells cannot properly use vitamin B12.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Homogentisic
Baseline
Homogentisic acid forms during phenylalanine and tyrosine breakdown, with significant rises linked to alkaptonuria, a rare inherited metabolic condition.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Phenylpyruvic
Baseline
Phenylpyruvic acid forms from phenylalanine and is best known for its connection to PKU (phenylketonuria), an inherited condition affecting phenylalanine processing.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Vitamin B6
Baseline
P5P is the active form of vitamin B6 your enzymes actually use.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Energy
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Biomarker
Included in
Aspartate Aminotransferase (AST)
Baseline
AST is an enzyme in liver, heart, and muscle, released when they are strained.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Carbon Dioxide, Total
Baseline
Total carbon dioxide (CO2) is a measure of the amount of carbon dioxide in your blood.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Cortisol
Baseline
Cortisol is a hormone made by the adrenal glands that helps you respond to stress and regulate various bodily functions.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
DHEA-Sulfate (DHEA-S)
Baseline
DHEA-Sulfate (DHEA-S) is a steroid hormone that is made by the adrenal glands and converted into sex hormones such as estrogen and testosterone.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Insulin-like Growth Factor 1 (IGF-1)
Baseline
IGF-1 reflects growth hormone activity, driving repair, muscle, and recovery¹.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Z Score
Baseline
IGF-1 Z Score compares your IGF-1 with the normal range for your age and sex.
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2-Oxoglutaric
Baseline
2-Oxoglutaric acid, also called alpha-ketoglutarate, is an energy-cycle step that also serves as a hub for handling amino acids and clearing ammonia.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
3-Hydroxyglutaric
Baseline
3-Hydroxyglutaric acid forms when the body breaks down lysine, hydroxylysine, and tryptophan, and is normally present in only small amounts in urine.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
3-Methylglutaconic
Baseline
3-Methylglutaconic acid is tied to breaking down leucine and to cellular energy production, and is closely related to its companion marker 3-methylglutaric acid.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
3-Methylglutaric
Baseline
3-Methylglutaric acid is produced when the body breaks down leucine, one of the three branched-chain amino acids important for energy production and muscle maintenance.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Aconitic
Baseline
Aconitic acid is an early energy-cycle step formed from citric acid by aconitase, an enzyme that requires iron and is sensitive to oxidative stress.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Adipic
Baseline
Adipic acid appears when the body uses a backup route to break down fat, with dietary contributions from food additives also possible.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Citric
Baseline
Citric acid opens the cells' energy engine, with the immediately following step run by the iron-dependent enzyme aconitase, making it sensitive to iron status.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Ethylmalonic
Baseline
Ethylmalonic acid is tied to how cells burn short-chain fats in the mitochondria, a process that leans on riboflavin (vitamin B2) as a helper.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Fumaric
Baseline
Fumaric acid is the energy-cycle step immediately after succinic acid, formed from it and passed onward to make malic acid in the mitochondrial energy machinery.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Lactic
Baseline
Lactic acid is produced during rapid energy generation without sufficient oxygen, with sources including exercise, infection, B-vitamin shortfall, or mitochondrial dysfunction.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Malic
Baseline
Malic acid is an energy-cycle step formed from fumaric acid, with conversion requiring vitamin B3 and magnesium as helpers in mitochondrial energy production.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Malonic
Baseline
Malonic acid can inhibit the SDH enzyme in the cells' energy engine and is also tied to fat metabolism, with two important areas of relevance.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Methylsuccinic
Baseline
Methylsuccinic acid arises from isoleucine processing and connects to how well mitochondria use fat for fuel, linked to type 2 diabetes among other conditions.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Pyruvic
Baseline
Pyruvic acid sits at the crossroads where sugar-derived fuel enters mitochondria for energy, with the enzyme involved blockable by toxic metals like arsenic and mercury.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Sebacic
Baseline
Sebacic acid is a marker of the backup fat-burning route, in the same family as adipic and suberic acids, with dietary contributions from MCT oils.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Suberic
Baseline
Suberic acid is a key fat-metabolism marker that builds up when the body switches to its backup fat-burning route because the main route is impaired.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Succinic
Baseline
Succinic acid is processed by the SDH enzyme, which operates in two mitochondrial energy systems at once, with the step depending on iron, riboflavin, and CoQ10.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Testosterone-to-Estradiol Ratio (T/E₂)
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Derived Biomarker
Baseline
The Testosterone-to-Estradiol Ratio (T/E₂) reflects androgen–estrogen balance.
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Gut health
0
Biomarker
Included in
Albumin/Globulin Ratio
Baseline
This ratio compares albumin with the globulins your immune system makes.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: albumin, globulin.
Albumin
Baseline
Albumin is a liver protein that tracks nutrition, fluid balance, and resilience¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Bilirubin-to-Albumin Ratio
Derived Biomarker
Baseline
The Bilirubin-to-Albumin Ratio (B/A Ratio) integrates bilirubin production and albumin-bound clearance.
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Globulin, Total
Baseline
Globulin is a type of protein that is made by the liver and the immune system.
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2-Hydroxyphenylacetic
Baseline
2-Hydroxyphenylacetic acid is produced mainly by gut bacteria breaking down compounds in the digestive tract, reflecting bacterial activity rather than human metabolism.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
3-Indoleacetic (C. stricklandii, C. subterminale & others)
Baseline
3-Indoleacetic acid is made from tryptophan by gut bacteria including Clostridia, reflecting how microbes handle this amino acid that also produces serotonin.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
3-Oxoglutaric
Baseline
Comes from gut yeasts and molds, and from your own energy metabolism.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
4-Cresol (C. difficile)
Baseline
4-Cresol is produced by Clostridia bacteria, particularly C. difficile, and interferes with dopamine beta-hydroxylase, the enzyme converting dopamine to norepinephrine.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
4-Hydroxybenzoic
Baseline
4-Hydroxybenzoic acid comes from two sources: gut bacterial activity, and parabens, preservatives found in cosmetics, personal-care products, and some processed foods.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
4-Hydroxyhippuric
Baseline
4-Hydroxyhippuric acid is a hippuric acid relative formed by gut bacteria processing dietary aromatic compounds, also connected to paraben exposure.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
4-Hydroxyphenylacetic (C. difficile, C. stricklandii & others)
Baseline
4-Hydroxyphenylacetic acid is a marker of Clostridia gut bacteria overgrowth, including C. difficile, which can be triggered by glyphosate or organophosphate pesticide exposure.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
4-Hydroxyphenyllactic
Baseline
4-Hydroxyphenyllactic acid comes from tyrosine processing and can also reflect gut bacterial activity, with two possible sources to weigh.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Arabinose
Baseline
Arabinose is a sugar from gut yeasts, and from plant foods like beets and grains.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Carboxycitric
Baseline
Carboxycitric acid is related to citric acid and reflects gut yeast activity.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Citramalic
Baseline
Citramalic acid is largely a byproduct of yeasts and molds living in your gut.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
DHPPA (Beneficial Bacteria)
Baseline
DHPPA is produced when beneficial gut bacteria like Lactobacilli and Bifidobacteria break down dietary plant polyphenols, marking helpful microbial activity.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Hippuric
Baseline
Hippuric acid comes from gut bacteria, dietary polyphenols, and solvent fumes.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
HPHPA (C. sporogenes, C. botulinum & others)
Baseline
HPHPA is produced by overgrowing Clostridia bacteria and blocks dopamine beta-hydroxylase, the enzyme responsible for converting dopamine into norepinephrine in the nervous system.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Oxalic
Baseline
Oxalates are mineral-binding compounds reaching the body from metabolism, gut yeasts and molds, and dietary sources like spinach, soy, beets, nuts, and tea.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Tartaric (Aspergillus)
Baseline
Tartaric acid comes from molds and yeasts, and from grapes, raisins, and wine.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Digestive Organ Age
Baseline
Captures the health of your digestive and liver systems.
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Protein, Total
Baseline
Total Protein measures the total amount of two classes of proteins found in the plasma: albumin and globulin.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Tissue Transglutaminase Ab
Baseline
tTG antibodies rise when your immune system reacts to gluten, as in celiac disease.
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Heart & vascular health
0
Biomarker
Included in
Apolipoprotein B
Baseline
ApoB counts the artery-clogging particles that carry your cholesterol¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Atherogenic Coefficient
Derived Biomarker
Baseline
This compares all your non-HDL cholesterol against the protective HDL portion.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: Total-C, HDL-C.
Atherogenic Index of Plasma
Derived Biomarker
Baseline
The Atherogenic Index of Plasma (AIP) is calculated as the logarithm of the ratio between triglycerides and HDL cholesterol.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: TG, HDL-C.
Castelli Risk Index I
Derived Biomarker
Baseline
The Castelli Risk Index I (CRI-I) is a cardiovascular risk marker calculated by dividing total cholesterol by HDL cholesterol.
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Castelli Risk Index II
Derived Biomarker
Baseline
The Castelli Risk Index II (CRI-II) is a lipid ratio calculated by dividing LDL cholesterol (“bad” cholesterol) by HDL cholesterol (“good” cholesterol).
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HDL Cholesterol
Baseline
HDL cholesterol is a type of cholesterol that is carried by high-density lipoproteins (HDL) in your blood.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
LDL Cholesterol
Baseline
LDL carries cholesterol into artery walls, where it builds plaque over time.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
LDL/HDL Ratio
Baseline
The LDL/HDL ratio shows the balance between 'bad' LDL cholesterol and 'good' HDL cholesterol.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
VLDL Cholesterol
Baseline
VLDL cholesterol stands for very-low-density lipoprotein cholesterol.
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Cholesterol, Total
Baseline
Total cholesterol is a measure of the total amount of cholesterol in your blood.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Non-HDL Cholesterol
Baseline
Non-HDL cholesterol is a stronger predictor of cardiovascular risk than LDL alone, especially in contexts with elevated triglycerides.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Cholesterol/HDL Ratio
Baseline
The Total Cholesterol/HDL ratio measures the balance between all cholesterol in the blood and the 'good' HDL cholesterol.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Carbon Dioxide, Total
Baseline
Total carbon dioxide (CO2) is a measure of the amount of carbon dioxide in your blood.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
High-sensitivity CRP
Baseline
hs-CRP detects low-grade inflammation linked to heart disease and aging.
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hsCRP-to-Albumin Ratio (CAR)
Derived Biomarker
Baseline
The CRP-to-Albumin Ratio (CAR) integrates inflammation (CRP) with nutritional/hepatic reserve (albumin).
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Cystatin C
Baseline
Cystatin C gauges kidney filtration without being skewed by muscle mass.
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Method Cystatin C: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis. Method eGFR: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Asymmetric dimethylarginine (ADMA)
Baseline
ADMA blocks the nitric oxide your blood vessels need to relax and widen.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Symmetric dimethylarginine (SDMA)
Baseline
SDMA is a close relative of ADMA, and an early marker of kidney filtration.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
GGT-to-HDL Cholesterol Ratio
Derived Biomarker
Baseline
The GGT-to-HDL Cholesterol Ratio (GGT/HDL-C) reflects oxidative stress versus lipid vascular protection.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Homocysteine
Baseline
Homocysteine is an amino acid that climbs when the methylation cycle stalls.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
LDL-C to Apolipoprotein B Ratio (LDL-C/ApoB)
Derived Biomarker
Baseline
The LDL Cholesterol-to-Apolipoprotein B Ratio (LDL-C/ApoB) reflects cholesterol content per LDL particle and indicates LDL particle size/density.
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Oxidized LDL
Baseline
Oxidized LDL is the portion of your LDL chemically damaged by free radicals.
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LDL Cholesterol / Total Cholesterol (Mass Ratio)
Derived Biomarker
Baseline
The LDL / Total Cholesterol ratio is a simple calculation that expresses the proportion of total cholesterol that is made up of low-density lipoproteins (LDL), commonly referred to as “bad cholesterol.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: LCL-C, Total Cholesterol.
Lipoprotein (a)
Baseline
Lp(a) is an inherited cholesterol particle that sticks to artery walls¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
METS-IR
Baseline
The Metabolic Score for Insulin Resistance (METS-IR) is a non-insulin-based index that estimates peripheral insulin sensitivity using fasting glucose, triglycerides, HDL cholesterol, and body mass index.
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Monocyte-to-HDL Ratio (MHR)
Derived Biomarker
Baseline
The Monocyte-to-HDL Ratio (MHR) reflects the balance between inflammation and cardiovascular protection.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: monocytes, HDL-C.
Neutrophil-to-HDL Cholesterol Ratio (NHR)
Derived Biomarker
Baseline
The Neutrophil-to-HDL Cholesterol Ratio (NHR) integrates innate immune activation (neutrophils) with HDL-C’s protective effects.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: neutrophils, HDL-C.
Non-HDL Cholesterol-to-Apolipoprotein B Ratio (Non-HDL-C/ApoB)
Derived Biomarker
Baseline
The Non-HDL Cholesterol-to-Apolipoprotein B Ratio (Non-HDL-C/ApoB) reflects cholesterol content per atherogenic particle across LDL, VLDL, IDL, and Lp(a).
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: Non-HDL-C, ApoB.
NON-HDL Total Cholesterol Ratio
Derived Biomarker
Baseline
The Non-HDL / Total Cholesterol ratio measures the proportion of your total cholesterol that is carried by potentially harmful lipoproteins - all cholesterol excluding HDL, which is considered “good cholesterol.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: Non-HDL-C, Total-C.
Triglyceride HDL Molar Ratio
Derived Biomarker
Baseline
The Triglyceride / HDL Cholesterol ratio is a powerful marker of insulin resistance, metabolic syndrome, and cardiovascular risk.
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Triglycerides
Baseline
Triglycerides are a type of fat, or lipid, found in your blood.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Triglyceride-to-Apolipoprotein B Ratio (TG/ApoB)
Derived Biomarker
Baseline
The Triglyceride-to-Apolipoprotein B Ratio (TG/ApoB) estimates the triglyceride load per atherogenic particle.
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TyG Index
Derived Biomarker
Baseline
The TyG Index is a metabolic risk marker calculated using fasting triglycerides and fasting glucose.
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Uric Acid
Baseline
Uric acid is a waste product that is formed when the body breaks down purines, which are chemicals found in some foods and drinks, such as red meat, organ meats, seafood, beer and fructose-sweetened beverages³.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Immune system
0
Biomarker
Included in
Alternaria alternata (m6) IgE
Baseline
An outdoor mold strongly linked to asthma flares, peaking in warm, dry weather.
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Aspergillus fumigatus (m3) IgE
Baseline
An indoor and outdoor mold that can trigger asthma and sinus symptoms.
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D. farinae (d2) IgE
Baseline
American dust mite, a year-round indoor trigger found in mattresses and carpets.
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Basophils
Baseline
Basophils are a type of white blood cell that the bone marrow makes.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Baso (Absolute)
Baseline
Basophils are a type of white blood cell that are part of the immune system.
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Bermuda Grass (g2) IgE
Baseline
A warm-season grass pollen common across the southern US, shedding much of the year.
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Cat Dander (e1) IgE
Baseline
Cat allergen from skin and saliva, light enough to linger indoors for months.
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Cockroach (i6) IgE
Baseline
Cockroach protein, a major driver of urban asthma and year-round nasal symptoms.
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Rough Pigweed (w14) IgE
Baseline
A summer weed pollen that cross-reacts with other pigweeds and with ragweed.
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Common Ragweed (w1) IgE
Baseline
The main US fall weed pollen, peaking late summer and travelling long distances.
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High-sensitivity CRP
Baseline
hs-CRP detects low-grade inflammation linked to heart disease and aging.
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Cyclic Citrullinated Peptide Antibody
Baseline
CCP antibodies target proteins in your joints and are highly specific to RA.
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Double-stranded DNA Antibodies
Baseline
dsDNA antibodies target your own DNA and are a hallmark of lupus.
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Dog Dander (e5) IgE
Baseline
Dog allergen from skin, saliva, and urine; levels vary widely between breeds.
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Eosinophils
Baseline
Eosinophils are a type of white blood cell that are part of the immune system².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Eos (Absolute)
Baseline
Eosinophils are a type of white blood cell and a component of the immune system, playing a crucial role in the body's defense against parasitic infections, allergens, and in mediating allergic reactions.
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Erythrocyte Sedimentation Rate
Baseline
Erythrocyte sedimentation rate (ESR), or sedimentation rate measures how quickly erythrocytes (red blood cells) settle at the bottom of a test tube over a period of one hour.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
D. pteronyssinus (d1) IgE
Baseline
European dust mite, a top year-round trigger living in bedding and soft furnishings.
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Ferritin
Baseline
Ferritin is a blood protein that contains iron¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Immunoglobulin A
Baseline
IgA is the antibody guarding your gut and airways, and it validates celiac testing.
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Immunoglobulin E
Baseline
Total IgE is your overall allergic baseline, before looking at specific triggers.
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Sycamore (t11) IgE
Baseline
A spring tree pollen from a widely planted street and park tree.
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Lymphocytes
Baseline
Lymphocytes are a type of white blood cell that are part of the immune system.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Lymphs (Absolute)
Baseline
Lymphocytes are a type of white blood cell that are integral to the immune system.
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Monocytes
Baseline
Monocytes are a type of white blood cell that are produced in the bone marrow and then enter the bloodstream⁴.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Monocytes (Absolute)
Baseline
Monocytes are a type of white blood cell that are part of the immune system.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Mountain Cedar (t6) IgE
Baseline
A winter tree pollen behind cedar fever in Texas and the southern plains.
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Mugwort (w6) IgE
Baseline
A late-summer weed pollen linked to hay fever and some food cross-reactions.
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Neutrophils
Baseline
Neutrophils are a type of white blood cell and the most abundant type of granulocytes in the bloodstream, playing a crucial role in the body's first line of defense against infection.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Neutrophils (Absolute)
Baseline
Neutrophils are a type of white blood cell and the most abundant type of granulocytes in the bloodstream, playing a crucial role in the body's first line of defense against infection.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Antinuclear Antibodies (ANA)
Baseline
The ANA screen looks broadly for antibodies aimed at your own cell nuclei.
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Penicillium notatum (m1) IgE
Baseline
A common indoor mold found in damp walls, carpets, and water-damaged rooms.
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Mean Platelet Volume (MPV)
Baseline
Mean Platelet Volume (MPV) measures the average size of your platelets - the small cell fragments in your blood that help with clotting, wound repair, and inflammation control.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Mean Platelet Volume
Baseline
Mean Platelet Volume (MPV) measures the average size of your platelets - the small cell fragments in your blood that help with clotting, wound repair, and inflammation control.
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Platelet Count
Baseline
Platelets are tiny components of your blood that help with clotting.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Rheumatoid Factor
Baseline
Rheumatoid factor is an antibody aimed at your own tissues, often raised in RA.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Birch (t3) IgE
Baseline
A spring tree pollen, and a common cause of hay fever and itching from raw fruit.
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Anti-SS-A 52kD Ab
Baseline
Anti-SS-A 52 is one of the two antibody subtypes linked to Sjogren's syndrome.
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Anti-Ro (SS-A) Ab
Baseline
Anti-Ro 60 is the other main SS-A subtype, also linked to Sjogren's and lupus.
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Sjogren's Antibody (SS-B)
Baseline
Anti-SS-B, or La, is an antibody strongly associated with Sjogren's syndrome.
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Smith Antibody
Baseline
Smith antibodies are highly specific to lupus when they show up.
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Timothy Grass (g6) IgE
Baseline
A widespread grass pollen and a leading cause of early-summer hay fever.
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RNP Antibody
Baseline
RNP antibodies point to mixed connective tissue disease and related conditions.
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White Blood Cells
Baseline
White blood cells are the immune system's front line against infection³.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
White Ash (t15) IgE
Baseline
A spring tree pollen from a tree common in parks and streets across the US.
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Elm (t8) IgE
Baseline
A tree pollen released in early spring, and again in autumn in some regions.
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White Mulberry (t70) IgE
Baseline
A spring tree pollen from a fast-spreading tree common in western US cities.
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Oak (t7) IgE
Baseline
A heavy spring tree pollen that coats surfaces and drives seasonal symptoms.
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Inflammation
0
Biomarker
Included in
High-sensitivity CRP
Baseline
hs-CRP detects low-grade inflammation linked to heart disease and aging.
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hsCRP-to-Albumin Ratio (CAR)
Derived Biomarker
Baseline
The CRP-to-Albumin Ratio (CAR) integrates inflammation (CRP) with nutritional/hepatic reserve (albumin).
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Erythrocyte Sedimentation Rate
Baseline
Erythrocyte sedimentation rate (ESR), or sedimentation rate measures how quickly erythrocytes (red blood cells) settle at the bottom of a test tube over a period of one hour.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Ferritin
Baseline
Ferritin is a blood protein that contains iron¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Ferritin-to-Albumin Ratio
Derived Biomarker
Baseline
The Ferritin-to-Albumin Ratio (FAR) integrates inflammation (ferritin) and nutritional status (albumin).
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: ferritin, albumin.
Lymphocyte-to-Monocyte Ratio (LMR)
Derived Biomarker
Baseline
The Lymphocyte-to-Monocyte Ratio (LMR) reflects the balance between adaptive immune function (lymphocytes) and innate immune activation (monocytes).
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: lymphocytes, monocytes.
Monocyte-to-HDL Ratio (MHR)
Derived Biomarker
Baseline
The Monocyte-to-HDL Ratio (MHR) reflects the balance between inflammation and cardiovascular protection.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: monocytes, HDL-C.
Monocyte-to-Lymphocyte Ratio (MLR)
Derived Biomarker
Baseline
The Monocyte-to-Lymphocyte Ratio (MLR) captures the balance between innate inflammatory processes (monocytes) and adaptive immune response (lymphocytes).
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: monocytes, lymphocytes.
Neutrophil-to-HDL Cholesterol Ratio (NHR)
Derived Biomarker
Baseline
The Neutrophil-to-HDL Cholesterol Ratio (NHR) integrates innate immune activation (neutrophils) with HDL-C’s protective effects.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: neutrophils, HDL-C.
Neutrophil-to-Lymphocyte-Platelet Ratio (NLPR)
Derived Biomarker
Baseline
The Neutrophil-to-(Lymphocyte × Platelet) Ratio (NLPR) combines neutrophils, lymphocytes, and platelets to reflect inflammatory burden, adaptive immunity, and repair capacity.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: neutrophils, lymphocytes, platelets.
Neutrophil-to-Lymphocyte Ratio (NLR)
Derived Biomarker
Baseline
The Neutrophil-to-Lymphocyte Ratio (NLR) reflects balance between innate and adaptive immunity.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: neutrophils, lymphocytes.
Platelet-to-Lymphocyte Ratio (PLR)
Derived Biomarker
Baseline
The Platelet-to-Lymphocyte Ratio (PLR) reflects thrombo-inflammatory burden and immune balance by combining platelet activity with adaptive immune status.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: platelets, lymphocytes.
Platelet-to-WBC Ratio (PWR)
Derived Biomarker
Baseline
The Platelet-to-WBC Ratio (PWR) compares platelet counts with total white blood cell counts.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: platelets, WBC.
Rheumatoid Arthritis Factor (RF)
Baseline
Rheumatoid factor is an antibody aimed at your own tissues, often raised in RA.
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Systemic Immune-Inflammation Index
Derived Biomarker
Baseline
The Systemic Immune-Inflammation Index (SII) integrates platelets, neutrophils, and lymphocytes.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: CBC differentials.
Systemic Inflammation Response Index (SIRI)
Derived Biomarker
Baseline
The Systemic Inflammation Response Index (SIRI) = (neutrophils × monocytes) / lymphocytes, integrating innate inflammatory activity with adaptive immune regulation.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: neutrophils, monocytes, lymphocytes.
White Blood Cells
Baseline
White blood cells are the immune system's front line against infection³.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Kidney health
0
Biomarker
Included in
Albumin
Baseline
Albumin is a liver protein that tracks nutrition, fluid balance, and resilience¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Appearance (Urine)
Baseline
Urine appearance describes the visual clarity of urine and reflects the presence or absence of suspended particles such as cells, bacteria, proteins, crystals, or mucus.
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Bacteria (Urine)
Baseline
Bacteria in urine sediment is checked by examining a urine sample under a microscope.
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Bilirubin (Urine)
Baseline
Urine bilirubin measures the presence of bilirubin, a yellow pigment produced from the breakdown of red blood cells, in the urine.
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Calcium
Baseline
Calcium is one of the most important and common minerals in your body.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Character (Urine)
Baseline
Urine character describes the visual clarity of urine and reflects the presence or absence of suspended particles such as cells, bacteria, proteins, crystals, or mucus.
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Chloride
Baseline
Chloride is a type of electrolyte that carries an electric charge and helps control the amount of fluids and the balance of acids and bases (pH balance) in your body¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Color (Urine)
Baseline
Urine color is an indirect visual indicator of kidney function, fluid balance, and systemic metabolism.
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Corrected Calcium (Albumin-adjusted)
Derived Biomarker
Baseline
Corrected calcium is a calculated value that adjusts your measured total serum calcium based on your albumin level.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: total calcium, albumin.
Creatinine
Baseline
Creatinine is a waste product that comes from the normal wear and tear on muscles of the body³.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
hsCRP-to-Albumin Ratio (CAR)
Derived Biomarker
Baseline
The CRP-to-Albumin Ratio (CAR) integrates inflammation (CRP) with nutritional/hepatic reserve (albumin).
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Crystals (Urine)
Baseline
Urine crystals are solid formations that can appear in urine sediment when certain dissolved substances precipitate out of solution.
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Cystatin C
Baseline
Cystatin C gauges kidney filtration without being skewed by muscle mass.
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Method Cystatin C: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis. Method eGFR: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Asymmetric dimethylarginine (ADMA)
Baseline
ADMA blocks the nitric oxide your blood vessels need to relax and widen.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Symmetric dimethylarginine (SDMA)
Baseline
SDMA is a close relative of ADMA, and an early marker of kidney filtration.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Epithelial Cells (Urine)
Baseline
Epithelial cells in urine sediment are counted by automated urinalysis.
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Squamous Epithelial Cells (Urine)
Baseline
Squamous epithelial cells are flat cells that line the outer portion of the urinary tract and surrounding skin.
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Estimated Glomerular Filtration Rate (eGFR)
Baseline
Estimated glomerular filtration rate (eGFR) is a calculation that reflects how well the kidneys are functioning by estimating the volume of blood they filter each minute, adjusted to a standard body surface area (mL/min/1.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Cystatin C–based eGFR
Baseline
Estimated glomerular filtration rate (eGFR) is a calculation that reflects how well the kidneys are functioning by estimating the volume of blood they filter each minute, adjusted to a standard body surface area (mL/min/1.
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Globulin, Total
Baseline
Globulin is a type of protein that is made by the liver and the immune system.
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Glucose (Urine)
Baseline
Urine glucose measures the presence of glucose, the body's primary fuel derived from dietary carbohydrates, in the urine.
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Granular Cast (Urine)
Baseline
Granular casts are cylindrical structures found in urine sediment that contain granular material from degenerating cells or aggregated proteins.
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Occult Blood (Urine)
Baseline
Urine occult blood measures the presence of red blood cells or hemoglobin in the urine that may be invisible to the naked eye.
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Hyaline Cast (Urine)
Baseline
Hyaline casts are cylindrical protein structures formed in the kidney tubules and detected in urine by automated urinalysis.
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Ketones (Urine)
Baseline
Urine ketones measure the presence of ketone bodies, which are byproducts of fat metabolism produced when the body uses fat instead of glucose as its primary energy source.
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Leukocyte Esterase (Urine)
Baseline
Urine leukocyte esterase measures the presence of esterase, an enzyme released by activated white blood cells (leukocytes) involved in immune defense.
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Glyceric
Baseline
Glyceric acid can rise from gut microbial overgrowth, nutrient shortfalls, high-fructose diets, or inherited factors, and feeds into the body's oxalate pathway.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Glycolic
Baseline
Glycolic acid is an upstream building block in the body's oxalate-producing pathway, with sources including normal metabolism, diet, and gut microbes.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Nitrite (Urine)
Baseline
Urine nitrite measures the presence of nitrites formed when certain bacteria convert naturally occurring urinary nitrates into nitrites.
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pH (Urine)
Baseline
Urine pH measures the acidity or alkalinity of urine and reflects the body's regulation of acid-base balance through the kidneys.
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Potassium
Baseline
Potassium is a mineral and an electrolyte that is critical for many body functions, including nerve signals, muscle contractions, heart rhythms, blood pressure, fluid balance, and pH balance¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Protein, Total
Baseline
Total Protein measures the total amount of two classes of proteins found in the plasma: albumin and globulin.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Protein (Urine)
Baseline
Urine protein measures the presence of protein in the urine and reflects the integrity of the kidney's filtration barrier.
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RBC Cast (Urine)
Baseline
Red blood cell (RBC) casts are cylindrical structures found in urine sediment that contain intact red blood cells trapped within a protein matrix.
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RBC (Urine)
Baseline
Urinary red blood cells (RBCs) measure the presence of intact red blood cells detected by urine microscopy.
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Sodium
Baseline
Sodium is a mineral and an electrolyte that is essential for many body functions, including nerve signals, muscle contractions, fluid balance, blood pressure, and pH balance¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Specific Gravity (Urine)
Baseline
Urine specific gravity measures the concentration of dissolved particles in urine relative to pure water and reflects the kidneys' ability to regulate fluid balance by concentrating or diluting urine.
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Uric Acid
Baseline
Uric acid is a waste product that is formed when the body breaks down purines, which are chemicals found in some foods and drinks, such as red meat, organ meats, seafood, beer and fructose-sweetened beverages³.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
BUN/Creatinine Ratio
Derived Biomarker
Baseline
BUN/Creatinine ratio is a calculation that compares the levels of blood urea nitrogen (BUN) and creatinine in your blood.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Blood Urea Nitrogen (BUN)
Baseline
BUN stands for blood urea nitrogen, which is a waste product that is produced when your body breaks down the protein in the foods you eat.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Urea-to-Creatinine Ratio
Baseline
The Urea-to-Creatinine Ratio (UCR) provides insight into renal stress, hydration, protein metabolism, and pre-renal vs.
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Uric Acid-to-HDL Cholesterol Ratio (UHR)
Derived Biomarker
Baseline
The Uric Acid-to-HDL Cholesterol Ratio (UHR) integrates oxidative/inflammatory load (uric acid) with HDL’s vascular protection.
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Urobilinogen (Urine)
Baseline
Urine urobilinogen measures the concentration of urobilinogen, a byproduct of bilirubin metabolism produced by intestinal bacteria.
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WBC (Urine)
Baseline
Urine white blood cells (WBCs) measure the presence of immune cells in the urine and indicate inflammatory activity within the urinary tract.
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Liver health
0
Biomarker
Included in
Albumin/Globulin Ratio
Baseline
This ratio compares albumin with the globulins your immune system makes.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: albumin, globulin.
Albumin
Baseline
Albumin is a liver protein that tracks nutrition, fluid balance, and resilience¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Alkaline Phosphatase (ALP)
Baseline
ALP is an enzyme that is found in various tissues, mainly in the liver and bone.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Alanine Aminotransferase (ALT)
Baseline
ALT is a liver enzyme that leaks into the blood when liver cells are strained.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Aspartate Aminotransferase (AST)
Baseline
AST is an enzyme in liver, heart, and muscle, released when they are strained.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Bilirubin Direct
Baseline
Direct bilirubin (also known as conjugated bilirubin) is a water-soluble form of bilirubin that has been processed by the liver.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Bilirubin Indirect
Baseline
Indirect bilirubin (also known as unconjugated bilirubin) is a fat-soluble waste product generated during the normal breakdown of red blood cells, specifically from the heme component of hemoglobin.
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Bilirubin, Total
Baseline
Bilirubin is a yellowish pigment that is produced when red blood cells break down in the body.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Bilirubin-to-Albumin Ratio
Derived Biomarker
Baseline
The Bilirubin-to-Albumin Ratio (B/A Ratio) integrates bilirubin production and albumin-bound clearance.
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Ferritin
Baseline
Ferritin is a blood protein that contains iron¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Ferritin-to-Albumin Ratio
Derived Biomarker
Baseline
The Ferritin-to-Albumin Ratio (FAR) integrates inflammation (ferritin) and nutritional status (albumin).
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: ferritin, albumin.
y-Glutamyl Transferase (GGT)
Baseline
γ-Glutamyl Transferase (GGT) is an enzyme primarily found in the liver, with elevated levels indicating potential liver dysfunction, oxidative stress, or cardiovascular risk¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
GGT-to-HDL Cholesterol Ratio
Derived Biomarker
Baseline
The GGT-to-HDL Cholesterol Ratio (GGT/HDL-C) reflects oxidative stress versus lipid vascular protection.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Globulin, Total
Baseline
Globulin is a type of protein that is made by the liver and the immune system.
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Indirect-to-Direct Bilirubin Ratio
Derived Biomarker
Baseline
The Indirect-to-Direct Bilirubin Ratio (I/D Ratio) reflects bilirubin metabolism, conjugation, and clearance.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: indirect bilirubin, direct bilirubin.
2-Hydroxybutyric (Methylation, Toxic exposure)
Baseline
2-Hydroxybutyric acid arises along the homocysteine-to-cysteine pathway that supplies glutathione production, sitting at the junction where detoxification and methylation meet.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
2-Hydroxyhippuric (Aspartame, Salicylates, or GI Bacteria)
Baseline
2-Hydroxyhippuric acid can rise from aspartame, dietary salicylates found in aspirin and many plant foods, or activity of certain gut bacteria.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
2-Oxo-4-methiolbutyric
Baseline
2-Oxo-4-methiolbutyric acid is connected to methionine processing, an amino acid central to methylation and glutathione production.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
N-Acetylcysteine (NAC) (Glutathione Precursor)
Baseline
NAC is a sulfur-containing raw material for glutathione, the body's master antioxidant, and can also directly bind certain toxins for removal.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Orotic (Ammonia Excess)
Baseline
Orotic acid is connected to the urea cycle that clears ammonia, the toxic waste from protein breakdown, accumulating when the system is strained.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Pyroglutamic (Glutathione)
Baseline
Pyroglutamic acid is part of the cycle that makes and recycles glutathione, the body's master antioxidant, acting as a pressure gauge for that system.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Protein, Total
Baseline
Total Protein measures the total amount of two classes of proteins found in the plasma: albumin and globulin.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Metabolic health
0
Biomarker
Included in
Adiponectin
Baseline
Adiponectin is made by fat cells and improves how you handle sugar and fat.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Alanine Aminotransferase (ALT)
Baseline
ALT is a liver enzyme that leaks into the blood when liver cells are strained.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Apolipoprotein B
Baseline
ApoB counts the artery-clogging particles that carry your cholesterol¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Aspartate Aminotransferase (AST)
Baseline
AST is an enzyme in liver, heart, and muscle, released when they are strained.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Atherogenic Coefficient
Derived Biomarker
Baseline
This compares all your non-HDL cholesterol against the protective HDL portion.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: Total-C, HDL-C.
Atherogenic Index of Plasma
Derived Biomarker
Baseline
The Atherogenic Index of Plasma (AIP) is calculated as the logarithm of the ratio between triglycerides and HDL cholesterol.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: TG, HDL-C.
Estim. Avg Glu (eAG)
Baseline
Hemoglobin A1c (HbA1c) reflects how much glucose (sugar) has become attached to your red blood cells over their 8–12 week lifespan.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Eag (mmol/l)
Baseline
Hemoglobin A1c (HbA1c) reflects how much glucose (sugar) has become attached to your red blood cells over their 8-12 week lifespan.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
C-Peptide
Baseline
C-peptide is released alongside insulin, showing how much your pancreas makes.
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Castelli Risk Index I
Derived Biomarker
Baseline
The Castelli Risk Index I (CRI-I) is a cardiovascular risk marker calculated by dividing total cholesterol by HDL cholesterol.
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Castelli Risk Index II
Derived Biomarker
Baseline
The Castelli Risk Index II (CRI-II) is a lipid ratio calculated by dividing LDL cholesterol (“bad” cholesterol) by HDL cholesterol (“good” cholesterol).
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Chloride
Baseline
Chloride is a type of electrolyte that carries an electric charge and helps control the amount of fluids and the balance of acids and bases (pH balance) in your body¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
HDL Cholesterol
Baseline
HDL cholesterol is a type of cholesterol that is carried by high-density lipoproteins (HDL) in your blood.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
LDL Cholesterol
Baseline
LDL carries cholesterol into artery walls, where it builds plaque over time.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
LDL/HDL Ratio
Baseline
The LDL/HDL ratio shows the balance between 'bad' LDL cholesterol and 'good' HDL cholesterol.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
VLDL Cholesterol
Baseline
VLDL cholesterol stands for very-low-density lipoprotein cholesterol.
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Cholesterol, Total
Baseline
Total cholesterol is a measure of the total amount of cholesterol in your blood.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Non-HDL Cholesterol
Baseline
Non-HDL cholesterol is a stronger predictor of cardiovascular risk than LDL alone, especially in contexts with elevated triglycerides.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Cholesterol/HDL Ratio
Baseline
The Total Cholesterol/HDL ratio measures the balance between all cholesterol in the blood and the 'good' HDL cholesterol.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Carbon Dioxide, Total
Baseline
Total carbon dioxide (CO2) is a measure of the amount of carbon dioxide in your blood.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
High-sensitivity CRP
Baseline
hs-CRP detects low-grade inflammation linked to heart disease and aging.
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Fructosamine
Baseline
Fructosamine reflects your average blood sugar over the past two to three weeks.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
y-Glutamyl Transferase (GGT)
Baseline
γ-Glutamyl Transferase (GGT) is an enzyme primarily found in the liver, with elevated levels indicating potential liver dysfunction, oxidative stress, or cardiovascular risk¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Glucose
Baseline
Glucose is a type of sugar that is your body's main source of energy.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Hemoglobin A1c
Baseline
Hemoglobin A1c is a type of hemoglobin, which is the protein in your red blood cells that carries oxygen from your lungs to the rest of your body.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Homeostatic Model Assessment for Beta-cell Function
Derived Biomarker
Baseline
A calculated value derived from fasting glucose and fasting insulin that estimates how well your pancreatic beta cells are producing insulin.
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Homeostatic Model Assessment of Insulin Resistance
Derived Biomarker
Baseline
A calculated value derived from fasting glucose and fasting insulin that estimates how effectively your body's insulin is keeping blood sugar in check.
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Homocysteine
Baseline
Homocysteine is an amino acid that climbs when the methylation cycle stalls.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Insulin Fasting
Baseline
Fasting insulin reflects how much insulin the pancreas produces after an overnight fast.
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Insulin
Baseline
Insulin is the pancreatic hormone that moves sugar from blood into your cells.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
LDL-C to Apolipoprotein B Ratio (LDL-C/ApoB)
Derived Biomarker
Baseline
The LDL Cholesterol-to-Apolipoprotein B Ratio (LDL-C/ApoB) reflects cholesterol content per LDL particle and indicates LDL particle size/density.
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LDL Cholesterol / Total Cholesterol (Mass Ratio)
Derived Biomarker
Baseline
The LDL / Total Cholesterol ratio is a simple calculation that expresses the proportion of total cholesterol that is made up of low-density lipoproteins (LDL), commonly referred to as “bad cholesterol.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: LCL-C, Total Cholesterol.
Leptin
Baseline
Leptin is made by fat cells and tells your brain you have enough energy stored.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
METS-IR
Baseline
The Metabolic Score for Insulin Resistance (METS-IR) is a non-insulin-based index that estimates peripheral insulin sensitivity using fasting glucose, triglycerides, HDL cholesterol, and body mass index.
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3-Hydroxybutyric
Baseline
3-Hydroxybutyric acid is a ketone the body produces from fat for fuel, with levels rising naturally during fasting, low-carb diets, and prolonged exercise.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Acetoacetic
Baseline
Acetoacetic acid is a ketone closely related to 3-hydroxybutyric acid, with the two rising and falling together as the body breaks down fat for energy.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Neutrophil-to-HDL Cholesterol Ratio (NHR)
Derived Biomarker
Baseline
The Neutrophil-to-HDL Cholesterol Ratio (NHR) integrates innate immune activation (neutrophils) with HDL-C’s protective effects.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: neutrophils, HDL-C.
Non-HDL Cholesterol-to-Apolipoprotein B Ratio (Non-HDL-C/ApoB)
Derived Biomarker
Baseline
The Non-HDL Cholesterol-to-Apolipoprotein B Ratio (Non-HDL-C/ApoB) reflects cholesterol content per atherogenic particle across LDL, VLDL, IDL, and Lp(a).
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: Non-HDL-C, ApoB.
NON-HDL Total Cholesterol Ratio
Derived Biomarker
Baseline
The Non-HDL / Total Cholesterol ratio measures the proportion of your total cholesterol that is carried by potentially harmful lipoproteins - all cholesterol excluding HDL, which is considered “good cholesterol.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: Non-HDL-C, Total-C.
Potassium
Baseline
Potassium is a mineral and an electrolyte that is critical for many body functions, including nerve signals, muscle contractions, heart rhythms, blood pressure, fluid balance, and pH balance¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Sodium
Baseline
Sodium is a mineral and an electrolyte that is essential for many body functions, including nerve signals, muscle contractions, fluid balance, blood pressure, and pH balance¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Triglyceride HDL Molar Ratio
Derived Biomarker
Baseline
The Triglyceride / HDL Cholesterol ratio is a powerful marker of insulin resistance, metabolic syndrome, and cardiovascular risk.
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Triglycerides
Baseline
Triglycerides are a type of fat, or lipid, found in your blood.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Triglyceride-to-Apolipoprotein B Ratio (TG/ApoB)
Derived Biomarker
Baseline
The Triglyceride-to-Apolipoprotein B Ratio (TG/ApoB) estimates the triglyceride load per atherogenic particle.
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TyG Index
Derived Biomarker
Baseline
The TyG Index is a metabolic risk marker calculated using fasting triglycerides and fasting glucose.
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Uric Acid
Baseline
Uric acid is a waste product that is formed when the body breaks down purines, which are chemicals found in some foods and drinks, such as red meat, organ meats, seafood, beer and fructose-sweetened beverages³.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Uric Acid-to-HDL Cholesterol Ratio (UHR)
Derived Biomarker
Baseline
The Uric Acid-to-HDL Cholesterol Ratio (UHR) integrates oxidative/inflammatory load (uric acid) with HDL’s vascular protection.
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Nutrients
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Biomarker
Included in
Vitamin D
Baseline
Vitamin D is an essential and multifunctional micronutrient.
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Method: Usually performed by FDA-cleared immunoassay in CLIA-certified, CAP-accredited laboratories. If an LC/MS method is used at the performing site, the assay is a laboratory-developed test (LDT) validated under CLIA and not cleared or approved by the FDA. Results support clinician interpretation and are not a stand-alone diagnosis.
Vitamin C
Baseline
Vitamin C supports immunity, collagen, and iron absorption, and must come from food.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Aspartate Aminotransferase (AST)
Baseline
AST is an enzyme in liver, heart, and muscle, released when they are strained.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Calcium
Baseline
Calcium is one of the most important and common minerals in your body.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Vitamin B12
Baseline
Vitamin B12 powers energy, nerve function, and healthy red blood cells.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Corrected Calcium (Albumin-adjusted)
Derived Biomarker
Baseline
Corrected calcium is a calculated value that adjusts your measured total serum calcium based on your albumin level.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: total calcium, albumin.
High-sensitivity CRP
Baseline
hs-CRP detects low-grade inflammation linked to heart disease and aging.
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hsCRP-to-Albumin Ratio (CAR)
Derived Biomarker
Baseline
The CRP-to-Albumin Ratio (CAR) integrates inflammation (CRP) with nutritional/hepatic reserve (albumin).
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Red Cell Dist Width (RDW)
Baseline
RDW is a measurement of the variability of red blood cell size.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Ferritin
Baseline
Ferritin is a blood protein that contains iron¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Folate (Folic Acid)
Baseline
Folate builds new cells and DNA, and works with B12 to drive methylation.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
RBC Folate
Baseline
RBC folate shows the folate stored inside your cells over recent months.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Hematocrit
Baseline
Hematocrit is a test that measures the proportion of blood volume occupied by red blood cells.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Hemoglobin
Baseline
Hemoglobin is a complex, iron-containing protein located within our red blood cells.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Homocysteine
Baseline
Homocysteine is an amino acid that climbs when the methylation cycle stalls.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Total Iron Binding Capacity (TIBC)
Baseline
TIBC is a blood test that measures your blood's ability (capacity) to attach (bind) to iron and carry it throughout your body².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Iron
Baseline
Iron is a mineral that is essential for many biological processes in the body, such as oxygen transport, muscle activity, mitochondrial function, DNA synthesis, and sensing of hypoxia⁵.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Iron Saturation
Baseline
Iron saturation is a biomarker that measures the percentage of iron bound to transferrin, a protein that moves iron throughout the body¹.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Magnesium RBC
Baseline
RBC magnesium shows the magnesium inside your cells, where most of it works.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Mean Cell Hemoglobin (MCH)
Baseline
MCH is the average mass of hemoglobin in a single red blood cell.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Mean Corpuscular Hemoglobin Concentration (MCHC)
Baseline
MCHC stands for mean corpuscular hemoglobin concentration.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Mean Cell Volume (MCV)
Baseline
MCV is the average size of your red blood cells, a clue to B12 and iron status.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
2-Hydroxyisocaproic
Baseline
2-Hydroxyisocaproic acid comes from processing leucine, one of the branched-chain amino acids, with breakdown leaning on B-vitamin-dependent enzymes including thiamine.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
2-Hydroxyisovaleric
Baseline
2-Hydroxyisovaleric acid arises from leucine breakdown, with rises potentially indicating a thiamine (B1) need to power branched-chain amino acid processing.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
2-Oxoisocaproic
Baseline
2-Oxoisocaproic acid is another leucine breakdown product, working alongside the other branched-chain amino acid markers, with processing dependent on B-vitamin-powered enzymes.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
2-Oxoisovaleric
Baseline
2-Oxoisovaleric acid forms from valine breakdown, one of the branched-chain amino acids, with processing relying on B-vitamin-powered enzymes including thiamine (B1).
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
3-Hydroxy-3-methylglutaric (Vitamin Q10 / CoQ10)
Baseline
3-Hydroxy-3-methylglutaric acid is connected to the pathway producing CoQ10, a mitochondrial nutrient used for energy generation that also acts as a cellular antioxidant.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
3-Methyl-2-oxovaleric
Baseline
3-Methyl-2-oxovaleric acid comes from isoleucine breakdown, the third of the branched-chain amino acids, with processing depending on B vitamins including thiamine (B1).
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Ascorbic (Vitamin C)
Baseline
Ascorbic acid is vitamin C, the well-known antioxidant essential for making collagen, supporting the immune system, and protecting cells from damage.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Glutaric (Vitamin B2 / Riboflavin)
Baseline
Glutaric acid cleanup depends on riboflavin (B2), with the B2-powered enzyme processing it and accumulation when B2 runs short, marking a B2 shortfall.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Methylcitric (Biotin / Vitamin H)
Baseline
Methylcitric acid is connected to biotin (vitamin H) and fat- and protein-derived fuel processing, with high values pointing to a functional biotin need.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Methylmalonic (Vitamin B12)
Baseline
MMA is normally cleared using vitamin B12, with the enzyme that processes it depending on B12, making elevations a reliable sign of low functional B12 supply.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Pantothenic (Vitamin B5)
Baseline
Pantothenic acid is vitamin B5, used by the body to make Coenzyme A (CoA), a master helper molecule central to energy production.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Phosphoric
Baseline
Phosphoric acid reflects phosphate level, an essential mineral for bones, energy storage in ATP, and many cell functions, shaped by diet and vitamin D.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Pyridoxic (Vitamin B6)
Baseline
Pyridoxic acid is the main breakdown product of vitamin B6, reflecting how much B6 the body is processing and clearing in urine.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Thymine
Baseline
Thymine is a DNA building block closely related to uracil, with its level reflecting folate (vitamin B9) status and management of these compounds.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Uracil
Baseline
Uracil is a building block of RNA, with its urinary level reflecting how the body handles these compounds, closely tied to folate (vitamin B9) status.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Vitamin K
Baseline
Vitamin K activates proteins that steer calcium into bone and away from arteries.
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Method: Shotgun metagenomic sequencing (CLIA 21D2062464); not cleared or approved by the FDA. Results reflect relative microbial abundance for wellness education purposes. Not intended to diagnose or treat disease and not a substitute for clinical consultation. Microbial associations are based on emerging scientific research and may change over time. Derived from laboratory results. This score or index is not an FDA-cleared test. It aids clinician-directed assessment and is not a stand-alone diagnosis.
Platelet-to-WBC Ratio (PWR)
Derived Biomarker
Baseline
The Platelet-to-WBC Ratio (PWR) compares platelet counts with total white blood cell counts.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: platelets, WBC.
Vitamin B6
Baseline
P5P is the active form of vitamin B6 your enzymes actually use.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Red Blood Cells
Baseline
Red blood cells (RBCs), also known as erythrocytes, are the most abundant type of blood cells in your body.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
RDW MCV Ratio
Derived Biomarker
Baseline
The RDW/MCV ratio is a red blood cell metric that compares two distinct aspects of red cell morphology:
- Red cell distribution width (RDW) which measures the *variation in size* among red blood cells in circulation.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis. Inputs: RDW, MCV.
Selenium
Baseline
Selenium is a trace mineral your thyroid and antioxidant defenses depend on.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Zinc, Plasma
Baseline
Zinc is a trace mineral behind immunity, wound healing, and cell division.
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Zinc, RBC
Baseline
RBC zinc reflects longer-term zinc status, and is steadier than plasma zinc.
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Sex hormones
0
Biomarker
Included in
17-Hydroxyprogesterone
Baseline
17-OHP is a steroid hormone that reflects how the adrenal glands are working.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Albumin
Baseline
Albumin is a liver protein that tracks nutrition, fluid balance, and resilience¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Dihydrotestosterone
Baseline
DHT is a potent androgen made from testosterone, acting on hair, skin, and prostate.
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DHEA-Sulfate (DHEA-S)
Baseline
DHEA-Sulfate (DHEA-S) is a steroid hormone that is made by the adrenal glands and converted into sex hormones such as estrogen and testosterone.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Estradiol
Baseline
Estradiol is the main estrogen, shaping cycles, bone, mood, and heart health.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Follicle Stimulating Hormone (FSH)
Baseline
FSH is a pituitary hormone that drives egg and sperm production¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Free Androgen Index
Derived Biomarker
Baseline
The Free Androgen Index (FAI) is a calculated ratio used to estimate the amount of biologically active (free) testosterone circulating in the bloodstream.
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Method: Derived from laboratory results. If any input is measured by a laboratory-developed test (LDT) validated under CLIA, that input is not cleared or approved by the FDA. This ratio/index itself is not FDA-cleared. Results support clinician interpretation and are not a stand-alone diagnosis. Inputs: total testosterone, SHBG.
PSA Free
Baseline
Free PSA is the portion of PSA not bound to proteins.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
PSA % Free
Baseline
PSA % Free is the percentage of PSA not bound to proteins.
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Luteinizing hormone (LH)
Baseline
LH is a pituitary hormone that triggers ovulation and testosterone production¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Anti-Mullerian Hormone
Baseline
AMH reflects ovarian reserve, the number of eggs you have remaining.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Progesterone
Baseline
Progesterone is a hormone that plays an important role in your reproductive system.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Prolactin
Baseline
Prolactin is a pituitary hormone; high levels can disrupt fertility and libido¹.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Psa Total
Baseline
PSA, or Prostate-Specific Antigen, is a protein primarily produced by prostate cells.
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Prostate Specific Antigen (PSA)
Baseline
PSA, or Prostate-Specific Antigen, is a protein primarily produced by prostate cells.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Sex Hormone Binding Globulin (SHBG)
Baseline
SHBG binds sex hormones, setting how much stays free and active in the body¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Free Testosterone
Baseline
Free testosterone is the small unbound share your tissues can actually use.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Testosterone, Bioavailable
Baseline
Bioavailable testosterone is the free plus loosely bound share reaching tissues.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Testosterone, Total
Baseline
Total testosterone counts all of it in your blood, most bound and unavailable.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Testosterone-to-Estradiol Ratio (T/E₂)
Derived Biomarker
Baseline
The Testosterone-to-Estradiol Ratio (T/E₂) reflects androgen–estrogen balance.
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Thyroid health
0
Biomarker
Included in
Albumin
Baseline
Albumin is a liver protein that tracks nutrition, fluid balance, and resilience¹².
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
DHEA-Sulfate (DHEA-S)
Baseline
DHEA-Sulfate (DHEA-S) is a steroid hormone that is made by the adrenal glands and converted into sex hormones such as estrogen and testosterone.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Free T3 (Triiodothyronine)
Baseline
Free T3 measures the unbound, biologically active portion of circulating T3.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Free Thyroxine Index
Baseline
The Free Thyroxine Index (FTI) is a calculated value that estimates the amount of unbound, biologically active thyroxine (free T4) circulating in your blood.
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Method: Derived from FDA-cleared laboratory results. This ratio/index is not an FDA-cleared test. It aids clinician-directed risk assessment and monitoring and is not a stand-alone diagnosis.
Selenium
Baseline
Selenium is a trace mineral your thyroid and antioxidant defenses depend on.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
T3 Uptake
Baseline
T3 Uptake (T3RU) is an indirect test that estimates how much of your thyroid-binding proteins - especially thyroxine-binding globulin (TBG) - are available to carry thyroid hormones in the blood.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
T4 (thyroxine) Total
Baseline
Thyroxine (T4) is one of the two main hormones produced by your thyroid gland (the other being triiodothyronine (T3)).
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Free Testosterone
Baseline
Free testosterone is the small unbound share your tissues can actually use.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Testosterone, Bioavailable
Baseline
Bioavailable testosterone is the free plus loosely bound share reaching tissues.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Testosterone, Total
Baseline
Total testosterone counts all of it in your blood, most bound and unavailable.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
Thyroglobulin Antibodies
Baseline
Thyroglobulin antibodies show the immune system targeting a key thyroid protein.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Thyroid Peroxidase (TPO) Ab
Baseline
TPO antibodies are a marker of the immune system attacking the thyroid gland.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Thyroid-Stimulating Hormone (TSH)
Baseline
TSH stands for thyroid stimulating hormone.
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Method: FDA-cleared clinical laboratory assay performed in CLIA-certified, CAP-accredited laboratories. Used to aid clinician-directed evaluation and monitoring. Not a stand-alone diagnosis.
Toxin exposure
0
Biomarker
Included in
Mercury, Blood
Baseline
Mercury is a naturally occurring heavy metal with no beneficial role in human biology.
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Method: Laboratory-developed test (LDT) validated under CLIA; not cleared or approved by the FDA. Results are interpreted by clinicians in context and are not a stand-alone diagnosis.
2,4-D
Baseline
2,4-D is a widely used weed killer found on lawns, crops, and in water.
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3-Phenoxybenzoic Acid
Baseline
3-PBA marks pyrethroids, the insecticides in most household bug sprays.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Aflatoxin M1
Baseline
Aflatoxin M1 is the best-studied mold toxin, mainly from grains, nuts, and dairy.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Aluminum (Al)
Baseline
Aluminum is a common environmental metal with no biological role in humans.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Antimony (Sb)
Baseline
Antimony is a metalloid with no biological role in humans.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Arsenic (As)
Baseline
Arsenic comes from groundwater, rice, and seafood, and is a known carcinogen.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Atrazine Mercapturate
Baseline
Atrazine is a corn herbicide and one of the most common water contaminants.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Barium (Ba)
Baseline
Barium comes from industrial dust, some ceramics, and contaminated water.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Beryllium (Be)
Baseline
Beryllium is a workplace metal used in aerospace, electronics, and alloys.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Bismuth (Bi)
Baseline
Bismuth comes mostly from stomach remedies and some cosmetics.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Bisphenol A (BPA)
Baseline
BPA comes from plastics, can linings, and receipts, and can act like estrogen.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Bisphenol S (BPS)
Baseline
BPS replaced BPA in many 'BPA-free' plastics and behaves much the same way.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Butylparaben
Baseline
Butylparaben is the most estrogen-active of the parabens used in cosmetics.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Cadmium (Cd)
Baseline
Cadmium is a persistent heavy metal with no biological role in humans.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Cesium (Cs)
Baseline
Cesium is found in soil and food, and mostly reflects what you eat.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Chaetoglobosin A
Baseline
Chaetoglobosin A comes from Chaetomium, a mold common in water-damaged buildings.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Diethylphosphate
Baseline
Diethylphosphate marks organophosphate pesticides used on produce.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Citrinin (Dihydrocitrinone)
Baseline
Citrinin comes from mold on stored grains and is mainly a concern for the kidneys.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Diphenyl Phosphate
Baseline
Diphenyl phosphate marks flame retardants in furniture, foam, and electronics.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Enniatin B
Baseline
Enniatin B comes from Fusarium mold, most often on wheat and other cereal grains.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Ethylparaben
Baseline
Ethylparaben preserves cosmetics, and often appears alongside other parabens.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Gadolinium (Gd)
Baseline
Gadolinium is a rare earth metal with no biological role in humans.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Gliotoxin
Baseline
Gliotoxin comes from Aspergillus and can dampen how well your immune system works.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Glyphosate
Baseline
Glyphosate is the world's most used herbicide, reaching you through food and water.
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HEMA
Baseline
HEMA marks ethylene oxide, used to sterilize medical kit and found in smoke.
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Lead (Pb)
Baseline
Lead is a persistent toxin with no safe level and no useful role in the body.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
MEOHP
Baseline
MEOHP is a second marker of DEHP, the most widely produced plastics softener.
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Mercury (Hg)
Baseline
Mercury is one of the most biologically reactive metals humans commonly encounter.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Methylhippuric Acid
Baseline
Methylhippuric acid marks xylene, a solvent in paints, glues, and fuel.
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Methylparaben
Baseline
Methylparaben is the most common preservative in cosmetics and personal care.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Mono-2-ethylhexyl phthalate (MEHP)
Baseline
MEHP marks exposure to DEHP, the plasticizer in soft plastics and medical tubing.
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Monobutyl phthalate (MBP)
Baseline
MBP marks dibutyl phthalate, found in nail products, adhesives, and coatings.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Monoethylphthalate (MEP)
Baseline
MEP marks diethyl phthalate, used to hold scent in fragrance and personal care.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Monoisobutyl phthalate (MiBP)
Baseline
MiBP marks isobutyl phthalate, another plasticizer common in cosmetics.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Mycophenolic Acid
Baseline
Mycophenolic acid comes from Penicillium mold and can suppress immune activity.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
NACE
Baseline
NACE marks acrylonitrile, from acrylic fibers, resins, and tobacco smoke.
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NADB
Baseline
NADB marks 1,3-butadiene, from vehicle exhaust, smoke, and synthetic rubber.
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NAE
Baseline
NAE marks vinyl chloride and related solvents used in making PVC plastic.
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NAP
Baseline
NAP is the most specific marker of benzene, mainly from smoke and traffic fumes.
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NAPR
Baseline
NAPR marks 1-bromopropane, a solvent in dry cleaning and metal degreasing.
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Nickel (Ni)
Baseline
Nickel is a naturally occurring metal with no essential biological role in humans.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
5-Hydroxymethyl-2-furoic (Aspergillus)
Baseline
HMFA can come from Aspergillus mold, or from roasted foods like coffee.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Furan-2,5-dicarboxylic (Aspergillus)
Baseline
Made by Aspergillus mold, and also formed in high-heat foods like coffee.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Furancarbonylglycine (Aspergillus)
Baseline
Formed when your liver tags Aspergillus compounds for excretion.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Mandelic
Baseline
Mandelic acid has two origins: normal phenylalanine breakdown, and as a major byproduct of styrene, an industrial chemical in plastics, resins, and packaging.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Tricarballylic (Fusarium)
Baseline
Linked to fumonisin toxins from Fusarium mold on grain and corn products.
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Method: GC-MS (Gas Chromatography/Mass Spectrometry) measuring organic acid metabolites in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in mmol/mol creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Ochratoxin A
Baseline
Ochratoxin A is one of the most commonly found mold toxins, from grains and coffee.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Oxybenzone
Baseline
Oxybenzone is a chemical sunscreen filter absorbed through skin.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Palladium (Pd)
Baseline
Palladium is a platinum-group metal with no biological role in humans.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Perchlorate
Baseline
Perchlorate comes from water and produce, and can block iodine uptake.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Phenylglyoxylic Acid
Baseline
Phenylglyoxylic acid marks styrene and ethylbenzene, from plastics and fumes.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Platinum (Pt)
Baseline
Platinum comes from catalytic converters, jewelry, and some chemotherapy.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Propylparaben
Baseline
Propylparaben preserves cosmetics and foods, and is weakly estrogen-like.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 17D0919496); not cleared or approved by the FDA. Results reported in µg/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Roridin E
Baseline
Roridin E is a trichothecene linked to Stachybotrys in water-damaged buildings.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Sterigmatocystin
Baseline
Sterigmatocystin is an aflatoxin precursor found in damp buildings and grains.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Tellurium (Te)
Baseline
Tellurium is a rare metal used in solar panels, alloys, and electronics.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Thallium (Tl)
Baseline
Thallium is a highly toxic heavy metal historically known for use in rodenticides.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Thorium (Th)
Baseline
Thorium is a naturally radioactive metal found in soil, ores, and dust.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Tin (Sn)
Baseline
Tin is a naturally occurring metal with no essential biological role in humans.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Tungsten (W)
Baseline
Tungsten comes from tools, alloys, and some industrial and military sites.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Uranium (U)
Baseline
Uranium occurs naturally in groundwater and soil, and is toxic to the kidneys.
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Method: ICP-MS (Inductively Coupled Plasma Mass Spectrometry) with creatinine normalization by Jaffe Reaction (CLIA 14D0646470); not cleared or approved by the FDA. Results in µg/g creatinine; reference intervals based on NHANES population data under non-provoked conditions. Not a stand-alone diagnosis; should be interpreted in clinical context.
Verrucarin A
Baseline
Verrucarin A is a trichothecene from Stachybotrys, the black mold of damp buildings.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Zearalenone
Baseline
Zearalenone comes from mold on grains and can act like estrogen in the body.
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Method: LC-MS/MS (Liquid Chromatography/Tandem Mass Spectrometry) measuring free (unconjugated) mycotoxins in urine (CLIA 17D0919496); not cleared or approved by the FDA. Results in ng/g creatinine. Not a stand-alone diagnosis; should be interpreted in clinical context.
Derived Biomarkers
Like all comprehensive health platforms, Superpower provides derived biomarkers. Derived biomarkers are standard clinical tools used by healthcare providers worldwide.
A derived biomarker is a value that is calculated from other directly measured biomarkers rather than being measured directly in the lab.
A derived biomarker is a value that is calculated from other directly measured biomarkers rather than being measured directly in the lab.
The following biomarkers Progesterone, Vitamin K, ADMA/SDMA, IGF-1, Thyroid Peroxidase, Lipoprotein Fractionation, NMR and Thyroglobulin Antibody are not currently offered for Superpower members residing in New York/New Jersey. Some methods are laboratory-developed tests (LDTs) validated under CLIA but not cleared or approved by the U.S. FDA. Public claims mirror the performing laboratory’s intended-use language. Clinicians interpret results in context and may order confirmatory testing where appropriate.
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What is biomarker testing?
At Superpower, biomarker testing is the foundation of everything we do. It’s not about guesswork, quick fixes, or “one-size-fits-all” health advice. It’s about data.
Biomarker testing measures the actual molecules in your blood, saliva, or other samples that reflect how your body is working at the deepest level.
These results are then mapped against optimal ranges so you can see where you stand — today, not years later when problems surface.
Why testing matters
- Detect early signs of conditions including cardiovascular disease, metabolic dysfunction, and hormonal imbalance to increase the chance for intervention and potential outcomes.
- Understand your health baseline to improve your energy, metabolism, and longevity, particularly by tracking related biomarkers over time.
- Monitor health changes in response to new diet, exercise, or supplement regimens, helping to objectively measure the impact of lifestyle adjustments.
- Personalize your health decisions, including assessing your risks and protocol options, rather than relying on average population data or standard guidelines alone.
FAQs
Biomarker testing can identify hidden health risks, nutritional deficiencies, hormone levels, or early signs of disease — allowing for targeted lifestyle or medical interventions before symptoms develop. To learn more, read our guides on specificillnesses and diseasesthat biomarker testing can assist with.
People interested in optimizing health, longevity, or athletic performance, men and women monitoring hormone status (including testosterone), or those with specific health concerns (like heart, thyroid, or metabolic health) all benefit from biomarker testing.
Our biomarker tests at Superpower require a simple blood draw — either at home or in a clinic. Some other tests use additional samples like urine or saliva, depending on what is being measured.
Yes, certain biomarkers are linked to risks for cardiovascular disease, diabetes, hormone imbalances, metabolic syndrome, and even some cancers, enabling early and personalized prevention strategies.
For most people, testing every 6–12 months is recommended for ongoing monitoring and tracking changes in health or the effectiveness of interventions, though frequency can vary based on goals and medical advice.
