OrganAge brings precision aging diagnostics to millions of americans

A joint statement from Max Marchione, Founder & CEO of Superpower, and Dr. David Furman, Stanford Professor and Director at the Buck Institute for Research on Aging.

At Superpower, we believe Americans should have access to the most precise and actionable diagnostics that science can offer.

Today we are launching OrganAge, developed in partnership with Dr. David Furman, head of the longevity lab at the Buck Institute for Research on Aging. It is the first time Dr. Furman's research on organ-level aging has been translated into a commercially available consumer test.

A single biological age tells you how you are aging on average. OrganAge tells you where to focus.

For more than a decade, Dr. Furman's lab has studied why some organs age faster than others, and what that reveals about long-term disease risk.¹ The algorithm powering OrganAge — published as DiseaseAge — was trained on data from 456,180 adults in the UK Biobank, the largest cohort ever assembled for a system-specific biological age model.² Rather than fitting to chronological age, the model was trained directly against cause-of-death mortality records, anchoring every score to a hard clinical endpoint. From a single blood draw, OrganAge produces a biological age for each of nine major systems: heart, brain, liver, kidneys, lungs, immune, metabolism, musculoskeletal and nervous.

The model has been externally validated. In the U.S. Health and Retirement Study, individuals with confirmed diagnoses such as high blood pressure, heart attack and congestive heart failure showed biologically older circulatory systems than the rest of their bodies, consistent with the model's predictions. Members in the top 5% of accelerated aging in metabolic, circulatory, respiratory and mental systems went on to develop diabetes, hypertension, lung disease and dementia at sharply elevated rates.²

The stakes are well documented. Individuals with accelerated heart aging have a 250% increased risk of heart failure.³ Accelerated brain and vascular aging independently predict Alzheimer's disease progression as strongly as plasma pTau-181, the leading blood-based biomarker for Alzheimer's.³ Roughly 1 in 5 healthy adults over 50 already has at least one organ aging at a strongly accelerated rate, and a standard checkup, built around population reference ranges rather than organ-specific aging trajectories, will rarely reveal which.³

The real value of OrganAge lies in identifying the systems aging fastest, then directing clinical and lifestyle interventions toward them. Progress in healthspan typically comes from finding the weakest link, not the average, and organ-level resolution is what makes targeted intervention possible.

At Superpower, we will continue to set a standard for science-backed, organ-level insight so Americans can extend not just lifespan, but healthspan.

References

‍1. Sayed N, et al. An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging. Nature Aging, 2021. doi.org/10.1038/s43587-021-00082-y

‍2. Fuentealba M, et al. Blood Omics Models for System-Specific Mortality Risk Estimation. bioRxiv, 2024. doi.org/10.1101/2024.11.27.625723‍

3. Oh HS, et al. Organ aging signatures in the plasma proteome track health and disease. Nature, 2023. doi.org/10.1038/s41586-023-06802-1